Application of 1130165-74-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1130165-74-0 as follows.
(1) A mixture of ethyl 4-bromo-3-fluorobenzoate (500 mg), tris(dibenzylideneacetone)dipalladium (0) (94 mg), (R)-(+)-(1,1′-binaphthalene-2,2′-diyl)bis(diphenylphosphine) (189 mg), cesium carbonate (1.98 g), (R)-pyrrolidin-3-ol (353 mg), and toluene (5 mL) was stirred for 1 hour under heating and refluxing. The reaction mixture was cooled to room temperature and then the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography [eluent; 70%-30% n-hexane/ethyl acetate] to obtain ethyl (R)-3-fluoro-4-(3-hydroxypyrrolidin-1-yl)benzoate (390 mg) as a brown oily substance. MS (ESI nm/z): 254 (M+H) RT (min): 1.41
According to the analysis of related databases, 1130165-74-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; FUJIFILM Corporation; Ookubo, Megumi; Sekine, Shinichiro; Mashiko, Tomoyuki; Kawai, Hyoei; Fukunaga, Hirofumi; US2020/17459; (2020); A1;,
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