Synthetic Route of 1126-46-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1126-46-1, name is Methyl 4-chlorobenzoate, This compound has unique chemical properties. The synthetic route is as follows.
EXAMPLE 8 Cross Coupling with a Zincate as the Nucleophile A solution of EtMgBr (3 M in Et2O, 0.9 mL) is added to a solution of Et2Zn (3 M in toluene, 1 mL) at -78 C. After stirring for 15 min, the resulting cold solution of the zincate is added dropwise to a solution of methyl 4-chlorobenzoate (354 mg, 2.10 mmol) and Fe(acac)3 (36 mg, 0.1 mmol) in THF (6 mL) and NMP (0.5 mL) at 0 C. causing a spontaneous color change from yellow to brown-black. Standard extractive work up followed by flash chromatography affords 4-ethylbenzoic acid methyl ester (93%) the analytical and spectroscopic data of which are identical to those of a commercial sample.
The chemical industry reduces the impact on the environment during synthesis Methyl 4-chlorobenzoate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Furstner, Alois; Leitner, Andreas; Mendez, Maria; US2003/220498; (2003); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics