Category: 112-63-0

Kisel, V. M.; Potikha, L. M.; Kovtunenko, V. A. published the artcile< Condensed isoquinolines. Part 9. Alkylation of 7,12-dihydro-5H-isoquino[2,3-a]quinazolin-5-ones>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is isoquinoquinazolinone benzyl halide alkylation; spiroisoquinoquinazolinindane preparation; diazadibenzopleiadene preparation.

The alkylation of 7,12-dihydro-5H-isoquino[2,3-a]quinazolin-5-one proceeds at N(6) or C(7) depending on the type of alkylating agent and reaction conditions. C(7)-alkylation occurs in the presence of base. The secondary alkylation of the 7-alkyl derivatives occurs at the same position under these conditions. Depending on the conditions, the reaction with ortho-xylylene dibromide leads to spiro[5H-isoquino-[2,3-a]quinazolin-7(12H),2′-indane]-5-one or 11-oxo-4b,5,10,16-tetrahydro-11H-10a-azonia-15b-azadibenzo[a,e]pleiadene bromide.

Chemistry of Heterocyclic Compounds (New York)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) published new progress about Alkylation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Qiangjun; Yin, Changlong; Li, Yongwei; Yang, Zhe; Tian, Zongying published the artcile< Pharmacokinetic interaction between peimine and paeoniflorin in rats and its potential mechanism>, Product Details of C19H34O2, the main research area is peimine paeoniflorin hepatoprotectant CYP3A4 Pgp pharmacokinetic interaction; CYP3A4; Drug–drug interaction; P-gp; transport.

Peimine and paeoniflorin can be combined for the treatment of cough in paediatrics. The interaction during the co-administration could dramatically affect the bioavailability of drugs. The interaction between peimine and paeoniflorin was investigated in this study. The pharmacokinetics of paeoniflorin (20 mg/kg) with or without the coadministration of peimine (5 mg/kg for 10 days before paeoniflorin) was orally investigated in Sprague-Dawley rats (n = 6). The group without the peimine was set as the control group. The metabolic stability of paeoniflorin was studied in rat liver with microsomes. The effect of peimine on the absorption of paeoniflorin was investigated with Caco-2 cell monolayers. The Cmax (244.98 ± 10.95 vs. 139.18 ± 15.14μg/L) and AUC(0-t) (3295.92 ± 263.02 vs. 139.18 ± 15.14 h·μg/L) of paeoniflorin was increased by peimine. The t1/2 was prolonged from 5.33 ± 1.65 to 14.21 ± 4.97 h and the clearance was decreased from 15.43 ± 1.75 to 4.12 ± 0.57 L/h/kg. Consistently, peimine increased the metabolic stability of paeoniflorin with rat liver microsomes with the increased t1/2 (56.78 ± 2.62 vs. 26.33 ± 3.15 min) and the decreased intrinsic clearance (24.42 ± 3.78 vs. 52.64 ± 4.47μL/min/mg protein). Moreover, the transportation of paeoniflorin was also inhibited by peimine as the efflux ratio decreased from 3.06 to 1.63. Peimine increased the systemic exposure of paeoniflorin through inhibiting the activity of CYP3A4 and P-gp. These results provide a reference for further in vivo studies in a broader population.

Pharmaceutical Biology (Abingdon, United Kingdom) published new progress about Combination chemotherapy. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Shao, Yuewen; Ba, Shuaijie; Sun, Kai; Gao, Guoming; Fan, Mengjiao; Wang, Junzhe; Fan, Huailin; Zhang, Lijun; Hu, Xun published the artcile< Selective production of valerolactone or 1,4-pentanediol from levulinic acid/esters over Co-based catalyst and importance of synergy of hydrogenation sites and acidic sites>, Quality Control of 112-63-0, the main research area is magnesium cobalt catalyst ethyl levulinate hydrogenation valerolactone pentanediol.

γ-Valerolactone (GVL) or 1,4-pentanediol (1,4-PDO) are the value-added chems., selectivities of which from conversion of levulinic acid/ester depend on balanced distribution of metallic sites and other active sites of the catalysts. In this study, Co-based catalysts with various precursors of LDH structures were synthesized to investigate the roles of hydrogenation, acidic and basic sites in the formation of GVL and 1,4-PDO from Et levulinate (EL). The results indicated that Al in Co-Mg-Al or Co-Al created acidic sites and facilitated cobalt dispersion by developing porous structures and strong interaction with Co species. Kinetic study indicated that the conversion of GVL controlled the formation rate of 1,4-PDO from EL. The superior catalytic activity and recyclability were observed over Co-Mg-Al and Co-Al catalysts, with the selectivity of both of GVL and 1,4-PDO reaching 98%, which was equivalent or superior to noble-metal based catalysts. Bronsted acidic sites in catalyst could facilitate the lactonization of Et 4-hydroxyvalerate to GVL and the ring-opening of GVL to 1,4-PDO, by cooperating with hydrogenation sites. Lewis acidic sites improved the adsorption of substrates and reaction intermediates, accelerating the ring-opening of GVL. The synergy between acidic sites together with hydrogenation sites was the key for achieving the excellent catalytic performance.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Hydrogenation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Han, Xiaolong; Jin, Yujuan; Wang, Bohua; Tian, Huafeng; Weng, Yunxuan published the artcile< Reinforcing and Toughening Modification of PPC/PBS Blends Compatibilized with Epoxy Terminated Hyperbranched Polymers>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is epoxy terminated hyperbranched polyester PPC PBS blend preparation property.

Polypropylene carbonate (PPC)/polybutylene succinate (PBS) blends were prepared by melt-blending with terminal epoxy-based hyperbranched polymers (EHBP) as modifier. The thermal properties, mech. properties, rheol. properties and fracture morphol. were characterized by dynamic thermomech. analyzer, thermogravimetric analyzer, electronic universal testing machine, rotating rheometer and scanning electron microscope. Upon addition of EHBP, the difference between the glass transition temperature of PPC and PBS became smaller, indicating the compatibility of PPC and PBS were improved by EHBP. Furthermore, by adding 0.5phr of EHBP, the impact strength increased from 9.55 to 17.31 kJ/m2, the elongation at break increased from 136.29 to 204.39%, and the tensile strength increased from 10.00 to 16.84 MPa. The fracture surface of the PPC/PBS blends became rough with the increase of EHBP, even with large filamentous structures and tiny holes, which further demonstrated that EHBP acted as an excellent toughening effect on PPC/PBS. Gel content anal. confirmed that both phys. and chem. micro-crosslinking were formed after incorporation of EHBP.

Journal of Polymers and the Environment published new progress about Branched polymer chains. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Isidor, Marie S.; Dong, Wentao; Servin-Uribe, Rogelio I.; Villarroel, Julia; Altintas, Ali; Ayala-Sumuano, J. Tonatiuh; Varela-Echavarria, Alfredo; Barres, Romain; Stephanopoulos, Gregory; Macotela, Yazmin; Emanuelli, Brice published the artcile< Insulin resistance rewires the metabolic gene program and glucose utilization in human white adipocytes>, Computed Properties of 112-63-0, the main research area is insulin resistance glucose white adipocyte.

In obesity, adipose tissue dysfunction resulting from excessive fat accumulation leads to systemic insulin resistance (IR), the underlying alteration of Type 2 Diabetes. The specific pathways dysregulated in dysfunctional adipocytes and the extent to which it affects adipose metabolic functions remain incompletely characterized. We interrogated the transcriptional adaptation to increased adiposity in association with insulin resistance in visceral white adipose tissue from lean men, or men presenting overweight/obesity (BMI from 19 to 33) and discordant for insulin sensitivity. In human adipocytes in vitro, we investigated the direct contribution of IR in altering metabolic gene programming and glucose utilization using 13C-isotopic glucose tracing. We found that gene expression associated with impaired glucose and lipid metabolism and inflammation represented the strongest association with systemic insulin resistance, independently of BMI. In addition, we showed that inducing IR in mature human white adipocytes was sufficient to reprogram the transcriptional profile of genes involved in important metabolic functions such as glycolysis, the pentose phosphate pathway and de novo lipogenesis. Finally, we found that IR induced a rewiring of glucose metabolism, with higher incorporation of glucose into citrate, but not into downstream metabolites within the TCA cycle. Collectively, our data highlight the importance of obesity-derived insulin resistance in impacting the expression of key metabolic genes and impairing the metabolic processes of glucose utilization, and reveal a role for metabolic adaptation in adipose dysfunction in humans.

International Journal of Obesity published new progress about Adipocyte. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Balaratnam, Sumirtha; Rhodes, Curran; Bume, Desta Doro; Connelly, Colleen; Lai, Christopher C.; Kelley, James A.; Yazdani, Kamyar; Homan, Philip J.; Incarnato, Danny; Numata, Tomoyuki; Schneekloth, John S. Jr published the artcile< A chemical probe based on the PreQ1 metabolite enables transcriptome-wide mapping of binding sites>, Related Products of 112-63-0, the main research area is PreQ metabolite chem probe transcriptome binding site mapping.

The role of metabolite-responsive riboswitches in regulating gene expression in bacteria is well known and makes them useful systems for the study of RNA-small mol. interactions. Here, we study the PreQ1 riboswitch system, assessing sixteen diverse PreQ1-derived probes for their ability to selectively modify the class-I PreQ1 riboswitch aptamer covalently. For the most active probe (11), a diazirine-based photocrosslinking analog of PreQ1, X-ray crystallog. and gel-based competition assays demonstrated the mode of binding of the ligand to the aptamer, and functional assays demonstrated that the probe retains activity against the full riboswitch. Transcriptome-wide mapping using Chem-CLIP revealed a highly selective interaction between the bacterial aptamer and the probe. In addition, a small number of RNA targets in endogenous human transcripts were found to bind specifically to 11, providing evidence for candidate PreQ1 aptamers in human RNA. This work demonstrates a stark influence of linker chem. and structure on the ability of mols. to crosslink RNA, reveals that the PreQ1 aptamer/ligand pair are broadly useful for chem. biol. applications, and provides insights into how PreQ1, which is similar in structure to guanine, interacts with human RNAs.

Nature Communications published new progress about Aptamers. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tamura, Yasumitsu; Tsunekawa, Masayoshi; Miyamoto, Tomohisa; Ikeda, Masazumi published the artcile< Syntheses and some properties of 4-acyl-1-methyl-2-azathiabenzene 1-oxides>, COA of Formula: C19H34O2, the main research area is azathiabenzene oxide; thiabenzene aza oxide; thiazine oxide; acylvinylsulfoximine cyclization; sulfoximine acylvinyl cyclization.

4-Acyl-1-methyl-2-azathiabenzene 1-oxides I [R = H, R1 = Me, OEt, R2 = Me; RR1 = (CH2)3, R2 = Me; R = R1 = Me, R2 = H] were prepared by base catalyzed cyclization of N-(2,2-diacylvinyl)dimethylsulfoximines which, in turn, were obtained by the reactions of (MeCO)2C:CHOEt, EtOCH:C(CO2Et)2, MeCOC(:CHOEt)CO2Et, and 2-acetyl-3-methoxy-2-cyclohexen-1-one with dimethylsulfoximine. Comparison of the phys. and chem. properties of the azathiabenzene 1-oxides with those of the corresponding 4-acyl-1-methylthiabenzene 1-oxides II suggests that both the ylidic and betaine like properties of the 2-azathiabenzene 1-oxides are much lower than those of the latter.

Journal of Organic Chemistry published new progress about Cyclization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zheng, Yucheng; Hu, Qingcai; Wu, Zongjie; Bi, Wanjun; Chen, Bin; Hao, Zhilong; Wu, Liangyu; Ye, Naixing; Sun, Yun published the artcile< Volatile metabolomics and coexpression network analyses provide insight into the formation of the characteristic cultivar aroma of oolong tea (Camellia sinensis)>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Camellia sinensis volatile metabolomics coexpression network analysis.

Finished oolong tea products with distinctly characteristic cultivar aromas generally have higher economic value. To advance our understanding of the aromatic differences between Camellia sinensis cv. Tieguanyin (TGY) and Jinguanyin (JGY) cultivars and their underlying formation mechanism, volatile metabolomics anal., electronic nose (EN) anal., sensory evaluation, and RNA sequencing were performed during this study. The EN and sensorial anal. showed a significant difference in odor characteristics between the two cultivars, which featured sweet floral and fruity aromas and green floral aromas, resp. A metabolomics anal. of tea products showed that linalool (floral, OAV = 50.6) and geraniol (rose-like and sweet, OAV = 1.9) may contribute to the characteristic aroma. The volatile determination at each stage during the oolong tea manufacturing process emphasized that the significant difference in linalool and geraniol contents in fresh leaves from the two cultivars and the increase rate were potential reasons for their characteristic aroma and suggested that the “”Tanqing”” treatment clarified and intensified the characteristic cultivar aroma. A linalool synthase CsLIN with the expected catalytic activity was identified by coexpression network analyses. Collectively, our work pinpoints two key aroma substances within two cultivars and elaborates on the potential cause of characteristic cultivar aroma formation.

LWT–Food Science and Technology published new progress about Camellia sinensis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jouandin, Patrick; Marelja, Zvonimir; Shih, Yung-Hsin; Parkhitko, Andrey A.; Dambowsky, Miriam; Asara, John M.; Nemazanyy, Ivan; Dibble, Christian C.; Simons, Matias; Perrimon, Norbert published the artcile< Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting>, COA of Formula: C19H34O2, the main research area is Drosophila TORC1 tissue growth lysosomal cystine fasting mitochondria.

Adaptation to nutrient scarcity involves an orchestrated response of metabolic and signaling pathways to maintain homeostasis. We find that in the fat body of fasting Drosophila, lysosomal export of cystine coordinates remobilization of internal nutrient stores with reactivation of the growth regulator target of rapamycin complex 1 (TORC1). Mechanistically, cystine was reduced to cysteine and metabolized to acetyl-CoA (acetyl-CoA) by promoting CoA metabolism In turn, acetyl-CoA retained carbons from alternative amino acids in the form of tricarboxylic acid cycle intermediates and restricted the availability of building blocks required for growth. This process limited TORC1 reactivation to maintain autophagy and allowed animals to cope with starvation periods. We propose that cysteine metabolism mediates a communication between lysosomes and mitochondria, highlighting how changes in diet divert the fate of an amino acid into a growth suppressive program.

Science (Washington, DC, United States) published new progress about Adipose tissue. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Emad, Ayat M.; Rasheed, Dalia M.; El-Kased, Reham F.; El-Kersh, Dina M. published the artcile< Antioxidant, Antimicrobial Activities and Characterization of Polyphenol-Enriched Extract of Egyptian Celery (Apium graveolens L., Apiaceae) Aerial Parts via UPLC/ESI/TOF-MS>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Apium graveolens antioxidant antimicrobial polyphenol UPLCESITOFMS; Apium graveolens; UPLC/ESI/TOF-MS; antimicrobial; antioxidant; celery.

Medicinal plant extracts are increasingly considered a major source of innovative medications and healthcare products. This study focused on preparing a polyphenol enriched water extract of Egyptian celery “”Apium graveolens L., Apiaceae”” aerial parts (TAE) in an endeavor to accentuate its antioxidant capacity as well as its antimicrobial activity. (TAE) of celery was partitioned against different organic solvents to yield dichloromethane (DCM), Et acetate (EAC), and butanol (BUOH) fractions. (TAE) and the organic fractions thereof besides the remaining mother liquor (ML) were all screened for their antioxidant capacity using various protocols viz. monitoring the reducing amplitudes for ferric ions (FRAP), and radical scavenging potentials of oxygen (ORAC), 2,2′-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and metal chelation assays. The examination procedure revealed both (TAE) extract and (DCM) fraction, to pertain the highest antioxidant potentials, where the IC50 of the (TAE) using ABTS and metal chelation assays were ca. 34.52 ± 3.25 and 246.6 ± 5.78μg/mL, resp. The (DCM) fraction recorded effective results using the FRAP, ORAC, and DPPH assays ca. 233.47 ± 15.14 and 1076 ± 25.73μM Trolox equivalent/mg sample and an IC50 474.4 ± 19.8μg/mL, resp. Addnl., both (TAE) and (DCM) fraction exerted antimicrobial activities recording inhibition zones (mm) (13.4 ± 1.5) and (12.0 ± 1.0) against Staphylococcus aureus and (11.0 ± 1.2) and (10.0 ± 1.3) against Escherichia coli, resp., with no anti-fungal activity. Min. inhibitory concentration (MIC) of (TAE) and (DCM) fraction were 1250 and 2500μg/mL, resp. UPLC/ESI/TOF-MS unveiled the chem. profile of both (TAE) and (DCM) fraction to encompass a myriad of active polyphenolic constituents including phenylpropanoids, coumarins, apigenin, luteolin, and chrysoeriol conjugates.

Molecules published new progress about Aliphatic acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics