Category: 112-63-0

Yao, Jingqing; Feng, Xinyu; Dai, Xinyu; Peng, Gang; Guo, Zhirui; Liu, Zhengxia; Wang, Min; Guo, Wenjun; Zhang, Peng; Li, Yuntao published the artcile< TMZ magnetic temperature-sensitive liposomes-mediated magnetothermal chemotherapy induces pyroptosis in glioblastoma>, Application of C19H34O2, the main research area is temozolomide liposome pyroptosis glioblastoma magnetic temperature magnetothermal chemotherapy; Glioblastoma; Pyroptosis; Temozolomide; Temperature-sensitive liposomes.

Glioblastoma (GBM) is the most fatal and common type of primary malignant tumors in central nervous system. Chemotherapy drugs are difficult to reach the encephalic region effectively due to blood-brain barrier (BBB), but functional nanoparticle drug carriers can help to solve the problem. Herein, we developed a controllable drug carrier called temozolomide magnetic temperature-sensitive liposomes (TMZ/Fe-TSL) to investigate its feasibility and mol. mechanisms on GBM. Our research found TMZ/Fe-TSL exposed to alternating magnetic field (AMF) could induce significantly GBM cell death and promote the production of ROS. It also showed that the expression of NLRP3, CASP1 and N-GSDMD was upregulated compared to the control group, while the expression of CASP3 showed a reverse change. The results indicated that TMZ/Fe-TSL exposed to the AMF was capable of inducing GBM cells death. And the way and mechanisms of cell death may involve in ROS and pyroptosis, but not apoptosis.

Nanomedicine (New York, NY, United States) published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Huang, Linwei; Liu, Wei; Zhao, Liang-Liang; Zhang, Zengyu; Yan, Xiaoyu published the artcile< Base-Catalyzed H/D Exchange Reaction of Difluoromethylarenes>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is deuteriodifluoromethyl arene preparation; difluoromethylarene deuteration.

The budding deuteriodifluoromethyl group (CF2D) is a potentially significant functional group in medicinal chem. Herein, authors investigated t-BuOK-catalyzed H/D exchange reaction of difluoromethylarenes in DMSO-d6 solution The method provides excellent deuterium incorporation at the difluoromethyl group. Meanwhile, the effect of a trace amount of D2O in DMSO-d6 solution on the deuteration reaction was also investigated.

Journal of Organic Chemistry published new progress about Aralkyl fluorides Role: SPN (Synthetic Preparation), PREP (Preparation) (deuterio). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kalu-Uka, Godwin Mong; Kumar, Sandeep; Kalu-Uka, Abraham Chinedu; Vikram, Shruti; Okorafor, Okore Okay; Kigozi, Moses; Ihekweme, Gina Odochi; Onwualu, Azikiwe Peter published the artcile< Prospects for biodiesel production from Macrotermes nigeriensis: Process optimization and characterization of biodiesel properties>, Category: esters-buliding-blocks, the main research area is biodiesel production macrotermes nigeriensis process optimization.

The use of insects as feedstock for biodiesel production has sparsely been studied and very little is known of the fuel properties and engine performance of insect biodiesel. In this study, biodiesel was initially produced from an insect feedstock M. nigeriensis, then its physicochem. properties were characterized. The biodiesel was produced via the three-step process of lipid extraction, acid esterification (1 wt% H2SO4) and alk. transesterification (0.5 wt% NaOH). The optimal reaction time, temperature and methanol-oil molar ratio for the acid-esterification process resulted in a free fatty acid conversion of 96.58%. The volumetric yield, fatty acid Me esters content and physicochem. properties of M. nigeriensis biodiesel were analyzed using various anal. equipment such as the GC-HRMS, and 1H NMR. Anal. of the production process showed that 86.54 vol% biodiesel was obtained from M. nigeriensis oil. Further anal. showed that the biodiesel contained 96.72% fatty acid Me esters. The composition of the fatty acid Me esters was found to be 48% saturated esters and 52% monosatd. esters. The biodiesel d. (841 kg m-3), viscosity (2.32 mm2 s-1), flash point (125°C), pour point (-15°C), cetane number (51.4), higher heating value (41.8 MJ kg-1) and acid value (0.44 mgKOH.g-1) were in compliance with the ASTM D6751 standards One of the important results to highlight is the remarkably low viscosity of the biodiesel, which is attributed to the high concentration of monounsaturated fatty acid Me esters. Lower viscosity of fuel helps to improve fuel atomization and combustion efficiency, and hence lower emissions. The absence of polyunsaturated fatty acid esters also indicates that the biodiesel will have good oxidation stability.

Biomass and Bioenergy published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gwak, Joo-Han; Awala, Samuel Imisi; Nguyen, Ngoc-Loi; Yu, Woon-Jong; Yang, Hae-Young; von Bergen, Martin; Jehmlich, Nico; Kits, K. Dimitri; Loy, Alexander; Dunfield, Peter F.; Dahl, Christiane; Hyun, Jung-Ho; Rhee, Sung-Keun published the artcile< Sulfur and methane oxidation by a single microorganism>, Application In Synthesis of 112-63-0, the main research area is Methylovirgula growth methanotrophy thiotrophy sulfur methane oxidation; facultative methanotrophy; mixotrophy; thiotrophy; wetland.

Natural and anthropogenic wetlands are major sources of the atm. greenhouse gas methane. Methane emissions from wetlands are mitigated by methanotrophic bacteria at the oxic-anoxic interface, a zone of intense redox cycling of carbon, sulfur, and nitrogen compounds Here, we report on the isolation of an aerobic methanotrophic bacterium, ′Methylovirgula thiovorans′ strain HY1, which possesses metabolic capabilities never before found in any methanotroph. Most notably, strain HY1 is the first bacterium shown to aerobically oxidize both methane and reduced sulfur compounds for growth. Genomic and proteomic analyses showed that soluble methane monooxygenase and XoxF-type alc. dehydrogenases are responsible for methane and methanol oxidation, resp. Various pathways for respiratory sulfur oxidation were present, including the Sox-rDsr pathway and the S4I system. Strain HY1 employed the Calvin-Benson-Bassham cycle for CO2 fixation during chemolithoautotrophic growth on reduced sulfur compounds Proteomic and microrespirometry analyses showed that the metabolic pathways for methane and thiosulfate oxidation were induced in the presence of the resp. substrates. Methane and thiosulfate could therefore be independently or simultaneously oxidized. The discovery of this versatile bacterium demonstrates that methanotrophy and thiotrophy are compatible in a single microorganism and underpins the intimate interactions of methane and sulfur cycles in oxic-anoxic interface environments.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Jiao; Song, Yan; Hwarari, Delight T.; Liang, Xin-hao; Ding, Jian-hao; Yan, Meng-wen; Wu, Fu-an; Wang, Jun; Sheng, Sheng published the artcile< Fatty acid synthases and desaturases are essential for the biosynthesis of α-linolenic acid and metamorphosis in a major mulberry pest, Glyphodes pyloalis walker ( Lepidoptera: Pyralidae )>, SDS of cas: 112-63-0, the main research area is fatty acid synthase desaturase linolenic metamorphosis Glyphodes; Glyphodes pyloalis; desaturases; fatty acid synthases; mulberry trees; α-linolenic acid.

Alpha linolenic acid is an essential unsaturated fatty acid in organisms. However, there is a large gap between α-linolenic acid accumulation and its synthesis mechanism in insects. Fatty acid synthases (FASs) and desaturases (Desats) are vital enzymes required for the synthesis of unsaturated fatty acids. The pupae of Glyphodes pyloalis (Lepidoptera: Pyralidae), which is a destructive pest of mulberry trees, contain the highest level of α-linolenic acid compared to other life-history stages. To further explore the synthesis mechanism of α-linolenic acid in G. pyloalis pupae, author constructed a pupal transcriptome dataset and identified 106 genes related to fatty acid metabolism from it. Among these, two fatty acid synthases (GpylFAS) and five desaturases (GpylDesat) were identified. A qRT-PCR validation revealed that GpylFAS1 and GpylDesat1, 2, 3, 5 were expressed highest at pupal stages. Furthermore, the content of α-linolenic acid decreased significantly after silencing GpylFAS1 and GpylDesat5, resp. Besides, knocking down GpylFAS1 or GpylDesat5 resulted in more malformed pupae and adults, as well as lower emergence rates. Meanwhile, silencing GpylFAS1 or GpylDesat5 affected the expressions of the other GpylFASs and GpylDesats. The present results illustrate the pivotal function of FASs and Desats in α-linolenic acid biosynthesis and metamorphosis in insects. Authors research also broadens the sources of unsaturated fatty acids, especially for α-linolenic acid from insects, and provides novel insights for the management of mulberry insect pests from the perspective of utilization rather than control.

Pest Management Science published new progress about Acyl carrier proteins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Tong; Meng, Qian; Lin, Lan; Yang, Li; Zhao, Wenjiao; Sun, Dequn published the artcile< Self-assembled dehydropeptide nanocarrier as a delivery system for antitumor drug temozolomide>, Formula: C19H34O2, the main research area is glioblastoma cell antitumor dehydropeptide nanocarrier temozolomide; Dehydropeptide; Drug delivery; Nanocarrier; Self-assembly; Temozolomide.

Stable mol. conformation and intermol. forces are essential for peptide self-assembly. In this study, one novel dehydropeptide (DDP) monomer (Boc-(Z)Cα,b-ΔPhe-Gly-NHMe, DDP 1) was prepared; its conformation was confirmed to be more stable than the normal peptide 2 by NMR (NMR) and X-ray crystal diffraction experiments DDP 1 was self-assembled to one novel dehydropeptide nanomaterial (DDPN 1). Fourier transform IR (FTIR) spectroscopy results showed that hydrogen bonding was the main driving force of self-assembly. Electron microscope images displayed that the DDPN 1 fibers were longer and more stable than peptide 2 nanomaterials. Results of cell activity and enzyme hydrolysis proved that DDPN 1 had excellent biocompatibility and resistance to the enzymic hydrolysis of protease K. Therefore, the DDPN 1 was used to load the antitumor drug temozolomide (TMZ). Due to intermol. hydrogen bonds formed between TMZ and DDPN 1, TMZ-loaded DDPN 1 had a high percent entrapment efficiency (EE) of 83.72 ± 4.30% (n = 8) and a percent drug loading efficiency (LE) of 6.70 ± 0.34% (n = 8), and the half-life of TMZ-loaded DDPN 1 was 2.5-3 times longer than that of TMZ at pH 7. The in vitro cell viability results revealed that TMZ-loaded DDPN 1 exhibited higher antitumor activity (IC50 = 552.1 μM) against U118-MG than that of TMZ (IC50 = 1980.1 μM), possibly because that U118-MG cells uptook more TMZ from TMZ-loaded DDPN 1 than from free TMZ directly. This study is expected to inspire the design of biocompatible nanocarriers applied for anti-enzymic hydrolysis in drug delivery systems.

Bioorganic Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Horia, Raymond; Nguyen, Dan-Thien; Eng, Alex Yong Sheng; Seh, Zhi Wei published the artcile< Using a Chloride-Free Magnesium Battery Electrolyte to Form a Robust Anode-Electrolyte Nanointerface>, Quality Control of 112-63-0, the main research area is chloride magnesium battery electrolyte robust anode electrolyte nanointerface; chloride-free electrolyte; magnesium battery electrolyte; magnesium bis(hexamethyldisilazide); rechargeable magnesium battery; tetrabutylammonium borohydride.

Magnesium bis(hexamethyldisilazide) (Mg(HMDS)2)-based electrolytes are compelling candidates for rechargeable magnesium batteries due to their high compatibility with magnesium metal anode. However, the usual combination of Mg(HMDS)2 with chloride salts limits their practical application due to severe corrosion of cell components and low anodic stability. Herein, we report for the first time, a chloride-free Mg(HMDS)2-based electrolyte in 1,2-dimethoxyethane. By chem. controlling the moisture content using tetrabutylammonium borohydride as a moisture scavenger, the electrolyte demonstrates outstanding electrochem. performance in magnesium plating/stripping, with an average Coulombic efficiency of 98.3% over 150 cycles, and is noncorrosive to cell components. Surface anal. and depth profiling of the magnesium metal anode reveals the formation of a robust solid electrolyte interphase at the anode-electrolyte nanointerface, which allows magnesium plating/stripping to occur reversibly. The electrolyte also demonstrates good compatibility with a copper sulfide nanomaterial cathode, which exhibits a high initial discharge capacity of 261.5 mAh g-1.

Nano Letters published new progress about Abstraction reaction. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nguyen, Xuan B.; Nakano, Yuji; Duggan, Nisharnthi M.; Scott, Lydia; Breugst, Martin; Lupton, David W. published the artcile< N-Heterocyclic Carbene Catalyzed (5+1) Annulations Exploiting a Vinyl Dianion Synthon Strategy>, HPLC of Formula: 112-63-0, the main research area is acrylate tethered divinyl ketone NHC catalyst diastereoselective cycloisomerization annulation; hexahydroindene tetralin stereoselective preparation vinyl dianion synthon; enonyl unsaturated ester NHC catalyst dimerization cycloisomerization annulation; cyclohexanone stereoselective preparation vinyl dianion synthon; N-heterocyclic carbenes; enantioselectivity; homoenolates; organocatalysis; synthons.

Direct polarity inversion of conjugate acceptors provides a valuable entry to homoenolates. N-heterocyclic carbene (NHC) catalyzed reactions, in which β-unsubstituted conjugate acceptors undergo homoenolate formation and C-C bond formation twice, have been developed. Specifically, the all-carbon (5+1) annulations give a range of mono- and bicyclic cyclohexanones (31 examples). In the first family of annulations, β-unsubstituted acrylates tethered to a divinyl ketone undergo cycloisomerization, providing hexahydroindenes and tetralins. In the second, partially untethered substrates undergo an intermol. (5+1) annulation involving dimerization followed by cycloisomerization. While enantioselectivity was not possible with the former, the latter proved viable, allowing cyclohexanones to be produced with high levels of enantiopurity (most >95:5 e.r.) and exclusive diastereoselectivity (>20:1 d.r.). Derivatizations and mechanistic studies are also reported.

Angewandte Chemie, International Edition published new progress about Cyclization catalysts, stereoselective. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Snider, Barry B.; Vo, Nha Huu; Foxman, Bruce M. published the artcile< Manganese(III)-based oxidative fragmentation-cyclization reactions of unsaturated cyclobutanols>, Synthetic Route of 112-63-0, the main research area is oxidative fragmentation cyclization unsaturated cyclobutanol; manganese acetate oxidation unsaturated cyclobutanol.

Allylic cyclobutanols, e.g., I, are oxidatively fragmented by Mn(OAc)3.2H2O in EtOH to give tertiary radicals. These tertiary radicals undergo both 6-endo-cyclization to the α,β-unsaturated ketone to afford α-keto radicals, and 5-exo-cyclization to provide β-keto cyclopentylmethyl radicals. The α-keto radicals produced by 6-endo-cyclization are reduced to ketones or dimerize. The β-keto radicals formed by 5-exo-cyclization are oxidized by Cu(OAc)2 to yield methylenecyclopentanones and rearrange to give 3-oxocyclohexyl radicals that are oxidized by Cu(OAc)2 to afford cyclohexenones. Thus, oxidation of I with 2 equiv Mn(OAc)3.2H2O and 1 equiv Cu(OAc)2 in EtOH for 1 h at reflux affords 22% methylenecyclopentanone II, 1.5% cyclohexenone III, and 44% tricyclic enone IV. Acetylenic cyclobutanols are oxidatively fragmented by Mn(OAc)3.2H2O in EtOH to provide tertiary radicals that cyclize to give α-keto vinyl radicals, which abstract a hydrogen atom to yield methylenecyclopentanones. Pentenylcyclobutanol V is oxidatively fragmented by Mn(OAc)3.2H2O to afford a tertiary radical which cyclizes to furnish cyclopentylmethyl radicals, which are oxidized by Cu(OAc)2 to methylenecyclopentane VI and an isomer.

Journal of Organic Chemistry published new progress about Cyclization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kobayashi, Nagao published the artcile< Lid-type inclusion of pyrene-1,3,6,8-tetrasulfonate anion by β-cyclodextrin>, Reference of 112-63-0, the main research area is inclusion lid type pyrenetetrasulfonate cyclodextrin; pyrenetetrasulfonate inclusion beta cyclodextrin.

UV absorption and induced CD studies have indicated a new type of inclusion behavior (‘lid-type’) in cyclodextrin-arene 1:1 host-guest complexes exemplified by the pyrene-1,3,6,8-tetrasulfonate-β-cyclodextrin complex.

Journal of the Chemical Society, Chemical Communications published new progress about 112-63-0. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics