Category: 112-63-0

Di Iorio, Nicola; Champavert, Florian; Erice, Agostino; Righi, Paolo; Mazzanti, Andrea; Bencivenni, Giorgio published the artcile< Targeting remote axial chirality control of N-(2-tert-butylphenyl)succinimides by means of Michael addition type reactions>, Quality Control of 112-63-0, the main research area is remote axial chirality control Michael addition tertbutylphenylsuccinimide.

The efficient desymmetrization of N-(2-tert-butylphenyl)maleimides was realized by means of a Michael addition reaction of a series of carbon nucleophiles generating the corresponding axially chiral succinimides in high yields. The use of (DHQD)2Pyr as catalyst was fundamental to achieve the remote control of the stereogenic chiral axis with the concurrent construction of adjacent quaternary and tertiary stereocenters.

Tetrahedron published new progress about Atropisomers. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xu, Peng; Wang, Handong; Pan, Hao; Chen, Jiakai; Deng, Chulei published the artcile< Anlotinib combined with temozolomide suppresses glioblastoma growth via mediation of JAK2/STAT3 signaling pathway>, SDS of cas: 112-63-0, the main research area is glioblastoma anlotinib temozolomide JAK2 STAT3 signal transduction; Anlotinib; Glioblastoma; Invasion; JAK2/STAT3/VEGFA signaling pathway; Migration; Proliferation.

Anlotinib protects against carcinogenesis through the induction of autophagy and apoptosis. The current study evaluated the role and mol. mechanisms of anlotinib in glioblastoma, and the effects of anlotinib in combination with temozolomide (TMZ). Cell Counting Kit-8 and colony-forming assays were used to evaluate cell viability. Cell migration and invasion were assessed by wound-healing, Transwell migration, and Matrigel invasion assays. Cellular apoptosis and cell cycle anal. were determined by flow cytometry. Angiogenesis was assessed using human umbilical vein endothelial cells (HUVECs). Vascular endothelial growth factor A (VEGFA) was measured by ELISA. Protein expression was determined by western blotting or immunofluorescence staining. The in vivo anti-glioblastoma effect was assessed with live imaging of tumor xenografts in nude mice. Anlotinib restricted the proliferation, migration, and invasion of glioblastoma cells in a dose-dependent manner. Tumor supernatant from glioblastoma cells treated with anlotinib inhibited angiogenesis in HUVECs. Anlotinib induced autophagy in glioblastoma cells by increasing Beclin-1 and microtubule-associated protein 1 light chain 3B (LC3B) levels. Mechanistically, anlotinib inhibited the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3)/VEGFA signaling pathway. STAT3 inhibition by S3I-201 decreased VEGFA and suppressed cellular proliferation and movement. TMZ enhanced the anti-glioblastoma ability of anlotinib. Finally, anlotinib inhibited tumor growth and JAK2/STAT3/VEGFA signaling in xenografts. Anlotinib exerts anti-glioblastoma activity possibly through the JAK2/STAT3/VEGFA signaling pathway. TMZ potentiated the anti-glioblastoma effect of anlotinib via the same signaling pathway, indicating the potential application of anlotinib as a treatment option for glioblastoma.

Cancer Chemotherapy and Pharmacology published new progress about Angiogenesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Zhiqing; Lv, Junshuai; Xie, Guanglin; Wang, Su; Ye, Yanshuai; Huang, Gaohua; Tan, Donlgi published the artcile< Effect of assisted hydrogen on combustion and emission characteristics of a diesel engine fueled with biodiesel>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is methyl ester diesel engine fuel combustion emission simulation.

In this paper, the effects of hydrogen assisted biodiesel with different fatty acid Me esters (FAMEs) proportion on cylinder pressure, cylinder temperature, indicated thermal efficiency (ITE), NOx emission, HC emission and CO emission of a marine medium speed diesel engine are studied. The corresponding CFD model is executed by CONVERGE coupled to CHEMKIN, and a chem. kinetic mechanism with 314 reactions and 98 species is developed to accurately simulate the fuel injection and combustion processes. The results show that cylinder pressure, cylinder temperature and ITE increased with increasing HEF. Compared with rapeseed Me ester (RME) and cottonseed Me ester (CSME), the cylinder pressures are increased by 16.39% and 16.30% for CSME-6%H2 and RME-6%H2 at 100% load, resp. The cylinder temperatures are increased by 7.42% and 7.14%, and ITE increased by 3.73% and 3.9%, resp. In addition, the HC and CO emissions decreased significantly with the increase in HEF, while NOx emission increased. Compared with pure CSME and RME, HC emissions are reduced by 70.97% and 72.22% for CSME-6%H2 and RME-6% H2, and CO emissions are reduced by 41.89% and 38.12% for CSME-6%H2 and RME-6% H2 at 100% load, resp. Overall, the strategy of using CSME-6% H2 mixed fuel for engine is not only economical and practical, but also can prevent performance loss and reduce emissions.

Energy (Oxford, United Kingdom) published new progress about Biodiesel fuel. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kumari, P. Krishna; Rao, B. Srinivasa; Mallesh, D.; Lingaiah, N. published the artcile< Niobium exchanged tungstophosphoric acid supported on titania catalysts for selective synthesis of 5-ethoxymethylfurfural from fructose>, Application In Synthesis of 112-63-0, the main research area is ethoxymethylfurfural preparation titania support tungstophosphoric acid catalyst property.

Various niobium contained tungstophosphoric acid (NbTPA) supported on titania catalysts were prepared and investigated their activity for selective synthesis of 5-ethoxymethylfurfural (EMF) from fructose in ethanol/THF solvent system. Physico-chem. properties of the catalysts were assessed by different spectroscopic approaches like X-ray diffraction, Laser Raman, BET-surface area, FT-IR, pyridine adsorbed FT-IR and temperature programmed desorption of ammonia. The results of characterization direct the existence of firm Keggin ion structure of Nb exchanged TPA and its well dispersed state on support. Lewis acidic sites were induced with the existence of Nb ions. The catalytic activity was interrelated to the catalyst acidity which was liable on the number of Nb ions present in TPA and the amount of NbxTPA supported on TiO2. Among all catalysts 20wt% Nb0.4TPA/TiO2 catalyst showed best catalytic performance toward EMF with a yield of 76% at 130°C after 6 h. The catalyst is recyclable without any depletion of activity.

Molecular Catalysis published new progress about Acidity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Alsubaiei, Sana Razhan M.; Alfawaz, Hanan A.; Amina, Musarat; Al Musayeib, Nawal M.; El-Ansary, Afaf; Ahamad, Syed Rizwan; Noman, Omar M.; Maini, Jaber A. published the artcile< Comparative chemical profiling and biological potential of essential oils of petal, choke, and heart parts of Cynara scolymus L. head>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Cynara essential oil petal choke heart part antibacterial antioxidant.

The essential oil and macroelemental composition of different parts of flower bud (petal, choke, and heart) of Cynara scolymus L. were explored and compared using gas chromatog. mass spectrometry (GC-MS) and inductively coupled plasma mass spectrometry (ICP-MS). Overall, 62 organic components were detected in the flower bud based on mass spectra characteristics and retention indexes. The essential oil extracted from the petals, choke, and bud showed the presence of thirty-one, twenty-one, and twenty-one compounds, resp., with linoleic acid and palmitic acid as the major components. 21 components were identified in the oil of the petals, comprising 94.45% of the total oil, in which linoleic acid Me ester, palmitic acid Me ester, octadecanoic acid Me ester, O-α-d-glucopyranoside, and heptyl oct-3-yl ester were the major constituents. Twenty-one compounds, representing 89.13% of the total oil, were detected in the choke oil. Linoleic acid Me ester, palmitic acid Me ester, and 2-methyl-1-hexadecanol were the main components. However, the edible heart oil contains twenty compounds, comprising 86.84% of the total oil. Cyclopropane butanoic acid, linoleic acid, Me ester, and palmitic acid were the major constituents. The anal. executed by ICP-MS revealed the presence of significant amounts of various inorganic elements in all the three samples. The extracted essential oils were tested for antibacterial, antioxidant, and anticancer activities. The results showed that the oil extracted from the petals of C. scolymus flower bud displayed the highest antibacterial, antioxidant, anti-inflammatory, and anticancer effects, as compared to choke and heart oils.

Journal of Chemistry published new progress about Anti-inflammatory agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Xingkuan; Fang, Xinqiang; Chi, Yonggui Robin published the artcile< cis-Enals in N-heterocyclic carbene-catalyzed reactions: distinct stereoselectivity and reactivity>, Reference of 112-63-0, the main research area is enal imine cyclization heterocyclic carbene; cyclic ketone stereoselective preparation; heterocyclic carbene stereoselective cyclization catalyst.

The first successful generation of cis-homoenolate equivalent from cis-enals under the catalysis of N-heterocyclic carbenes (NHCs) has been realized. The cis-homoenolate intermediates undergo effective reactions with α,β-unsaturated imines to afford chiral cyclic ketone products, e.g., I and II. Compared to the trans-enals, cis-enals show different stereoselectivities and new reactivity patterns.

Chemical Science published new progress about Cyclic ketones Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

dos Santos Pedroso-Fidelis, Giulia; de Melo, Maria Eduarda; Possato, Jonathann Correa; Fernandes, Bruna Barros; De Pieri, Ellen; Cercena, Rodrigo; Dal-Bo, Alexandre Goncalves; Feuser, Paulo Emilio; Machado-de-Avila, Ricardo Andrez published the artcile< Temozolomide associated to gold nanoparticles promoted a synergic effect and apoptosis when exposed to melanoma cells>, Application In Synthesis of 112-63-0, the main research area is temozolomide gold nanoparticle synergic effect apoptosis melanoma.

Temozolomide (TMZ) is prescribed primarily because of its known ability to cross the blood-brain barrier, being a potentially chemotherapic drug for cancer treatment. However, it has dose-limiting hemotoxicity and rapid hydrolysis, which limits its anti-tumor efficacy. On the other hand, recent studies have shown that gold nanoparticles (GNPs) with their biocompatibility and cytotoxic potential in tumor cells can be combined with chemotherapy leading to an improvement in the existing treatment. Thus, this work aimed to evaluate the cytotoxic effects of TMZ associated with GNPs (T-GNPs) on B16F10 cells. Different GNPs were successfully synthesized, and the results showed that there was an electrostatic interaction between TMZ and GNPs, not changing their physicochem. properties. TMZ associated with GNPs exposed on B16F10 cells presented a cytotoxic effect even more pronounced than free TMZ. In addition, different T-GNPs did not induced cytotoxic effect on non-tumor cells (NIH3T3 and red blood cells). A synergism between TMZ and GNPs was observed, inducing B16F10 cell death by apoptosis.

Journal of Nanoparticle Research published new progress about Apoptosis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gao, Guoming; Lv, Mingxuan; Shao, Yuewen; Gao, Guanggang; Zhao, Hui; Zhang, Shu; Wang, Yi; Duan, Ran; Chen, Qifeng; Hu, Xun published the artcile< Crystal facet-dependent activity of h-WO3 for selective conversion of furfuryl alcohol to ethyl levulinate>, Computed Properties of 112-63-0, the main research area is crystal facet WO3 furfuryl alc ethyl levulinate.

The use of WO3 as an acid catalyst has received extensive attention in recent years. However, the correlation between the catalytic activity and the predominantly exposed surface with varied acidic sites needs further understanding. Herein, the effects of the Bronsted and Lewis acid sites of different crystal facets of WO3 on the catalytic conversion of furfuryl alc. (FA) to Et levulinate (EL) in ethanol were investigated in detail. A yield of EL up to 93.3% over WO3 with the (110) facet exposed was achieved at 170°C, while FA was mainly converted to polymers over (001) faceted nanosheets and nanobelts with exposed (002) and (100) facets. This was attributed to the different distribution of the acidic sites on different exposed crystal facets. The (110) faceted WO3 possessed abundant and strong Bronsted acid sites, which favored the conversion of FA to EL, while the (100) faceted WO3 with stronger Lewis acid sites and weaker Bronsted acid sites mainly led to the formation of polymers. In addition, the (110) faceted WO3 showed excellent sustainability in comparison with the (100) faceted counterpart.

Physical Chemistry Chemical Physics published new progress about Crystal morphology. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Veteska, Marek; Pospisil, Miroslav; Melanova, Klara; Benes, Ludvik; Zima, Vitezslav published the artcile< Structure analysis of hydrotalcite intercalated with pyrenetetrasulfonate; experiments and molecular modelling>, Product Details of C19H34O2, the main research area is pyrenetetrasulfonate hydrotalcite intercalated structure.

The structure of pyrenetetrasulfonate intercalated with hydrotalcite, having the formula [Zn0.68Al0.32(OH)2][(C16H6O12S4)0.08·xH2O], was proposed based on mol. simulations combined with exptl. data (X-ray powder diffraction, thermogravimetry). Calculations were done for samples kept at various relative humidities (0%, 84%, 98%). The appropriate models were selected from comparison of calculated and measured diffraction patterns. Modeling revealed the arrangement of pyrenetetrasulfonate anions, and the positions and the amount of water mols. in the interlayer space of the host structure. The results confirmed a large variability in the arrangement of the guest species. In the sample without water mols. (0% RH), pyrenetetrasulfonate anions formed a layer at the center of the interlayer distance. For the sample kept at 84% RH, the anions formed two layers at the thirds of the interlayer. For the sample kept at 98% RH, the anions became tilted with respect to the layered double hydroxides (LDH) layers and are less organized. Water mols. were arranged in three distinct planes: one in the middle and two at the quarters of interlayer distance. The number of water mols. obtained by the modeling basically agrees with the water content as measured by thermogravimetry.

Journal of Molecular Modeling published new progress about Intercalation compounds Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), PROC (Process), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Napolitano, Gaetana; Fasciolo, Gianluca; Magnacca, Nunzia; Goglia, Fernando; Lombardi, Assunta; Venditti, Paola published the artcile< Oxidative damage and mitochondrial functionality in hearts from KO UCP3 mice housed at thermoneutrality>, Synthetic Route of 112-63-0, the main research area is UCP oxidative damage heart mitochondria thermoneutrality phosphorylation; Calnexin; EIF2α; GRP78 BIP; Heart; Hsp 60; Mitochondrial complexes; Oxidative stress; Oxygen consumption; Thermoneutrality; UCP3.

The antioxidant role of mitochondrial uncoupling protein 3 (UCP3) is controversial. This work aimed to investigate the effects of UCP3 on the heart of mice housed at thermoneutral temperature, an exptl. condition that avoids the effects of thermoregulation on mitochondrial activity and redox homeostasis, preventing the alterations related to these processes from confusing the results caused by the lack of UCP3. WT and KO UCP3 mice were acclimatized at 30°C for 4 wk and hearts were used to evaluate metabolic capacity and redox state. Tissue and mitochondrial respiration, the activities of the mitochondrial complexes, and the protein expression of mitochondrial complexes markers furnished information on mitochondrial functionality. The levels of lipid and protein oxidative damage markers, the activity of antioxidant enzymes, the reactive oxygen species levels, and the susceptibility to in vitro Fe-ascorbate-induced oxidative stress furnished information on redox state. UCP3 ablation reduced tissue and mitochondrial respiratory capacities, not affecting the mitochondrial content. In KO UCP3 mice, the mitochondrial complexes activities were lower than in WT without changes in their content. These effects were accompanied by an increase in the level of oxidative stress markers, ROS content, and in vitro susceptibility to oxidative stress, notwithstanding that the activities of antioxidant enzymes were not affected by UCP3 ablation. Such modifications are also associated with enhanced activation/phosphorylation of EIF2α, a marker of integrated stress response and endoplasmic reticulum stress (GRP778 BIP). The lack of UCP3 makes the heart more prone to oxidative insult by reducing oxygen consumption and increasing ROS. Our results demonstrate that UCP3 helps the cell to preserve mitochondrial function by mitigating oxidative stress.

Journal of Physiology and Biochemistry published new progress about Ablation. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics