Category: 112-63-0

Bohne, C.; Abuin, E. B.; Scaiano, J. C. published the artcile< Triplet-triplet annihilation of pyrene derivatives as mobility probes in sodium 1,4-bis(2-ethylhexyl)sulfosuccinate/water/isooctane reversed micelles>, Electric Literature of 112-63-0, the main research area is micelle Aerosol OT pyrene fluorescence probe; triplet annihilation pyrene probe AOT micelle; reverse micelle interaction pyrene probe mobility.

Triplet-triplet annihilation (TTA) of pyrene probe mols. was used as a probe to study mobility of AOT reversed micelles in the microsecond time domain. Inter- and intramicellar processes can be differentiated by using different probe-to-micelle concentration ratios. The TTA for micelles containing only 1 pyrene mol. occurs with a rate constant of ∼1/3 the value for the diffusion controlled limit and it is ascribed to an intermicellar process in which the collision of triplets does not require the contact of water cores of the 2 micelles. The delayed fluorescence excimer-to-monomer (E/M) intensity ratio resulting from TTA is much lower than the one observed in homogeneous solution, indicating that the microenvironment for triplet-triplet encounter is more rigid when compared to solutions The TTA from micelles containing >1 probe (multiple occupancy) show initially a higher E/M intensity ratio for the delayed emission than the one observed for intermicellar processes, indicating that when 2 pyrenes are in the same micelle a more favorable geometry for excimer formation exists in the triplet-triplet encounter complex. A decrease with time of the E/M intensity ratio is observed under multiple occupancy conditions.

Langmuir published new progress about Diffusion. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kim, Hichul; El-Khoury, Victoria; Schulte, Nadine; Zhan, Tianzuo; Betge, Johannes; Cousin, Loic; Felli, Emanuele; Pessaux, Patrick; Ogier, Arnaud; Opitz, Oliver; Ku, Bosung; Ebert, Matthias P.; Kwon, Yong-Jun published the artcile< Personalized functional profiling using ex-vivo patient-derived spheroids points out the potential of an antiangiogenic treatment in a patient with a metastatic lung atypical carcinoid>, Product Details of C19H34O2, the main research area is human metastatic lung atypical carcinoid spheroid bevacizumab capecitabine; Personalized functional profiling; antiangiogenic therapy; drug screening; lung carcinoid; neuroendocrine tumors; personalized medicine; pharmacotyping; precision medicine; spheroids.

Lung carcinoids are neuroendocrine tumors representing 1 to 2% of lung cancers. This study outlines the case of a patient with a metastatic lung atypical carcinoid who presented with a pleural effusion and progression of liver metastases after developing resistance to conventional treatments. Personalized functional profiling (PFP), i.e. drug screening, was performed in ex-vivo spheroids obtained from the patient liver metastasis to identify potential therapeutic options. The drug screening results revealed cediranib, an antiangiogenic drug, as a hit drug for this patient, from a library of 66 Food and Drug Administration (FDA)-approved and investigational drugs. Based on the PFP results and the reported evidence of clin. efficacy of bevacizumab and capecitabine combination in gastro-intestinal neuroendocrine tumors, this combination was given to the patient. Four months later, the pleural effusion and pleura carcinosis regressed and the liver metastasis did not progress. The patient experienced 2 years of a stable disease under the PFP-guided personalized treatment.

Cancer Biology & Therapy published new progress about Antiangiogenic agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Schultz, Terry W.; Hewitt, Mark; Netzeva, Tatiana I.; Cronin, Mark T. D. published the artcile< Assessing applicability domains of toxicological QSARs: definition, confidence in predicted values, and the role of mechanisms of action>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is modeling predictive toxicity QSAR Tetrahymena aromatic compound.

There are many issues relating to the use of Quant. Structure – Activity Relationships (QSARs) to make predictions for regulatory purposes. Among those issues, characterization of models and the development of suitable tools to determine applicability domains rank as the more important. With regard to aquatic toxicol., QSARs for acute effects (e.g., IGC50-1) often take the form of a hydrophobic [i.e., Logarithm of the 1-Octanol/Water Partition Coefficient (log P)]-electrophilic [e.g., Maximum Acceptor Superdelocalizability (Amax)]-dependent, regression-based model. In this study, the applicability domain of a model for the toxicity of aromatic compounds to Tetrahymena pyriformis [log (IGC50-1) = 0.545(0.015) log P + 16.2(0.62) Amax-5.91(0.20); n = 384, r2 (adj) = 0.859, r2(pred) = 0.856, s = 0.275, F = 1163, Pr > F = 0.0001] was assessed. The structural and physicochem. domains of the model were characterized using two test sets of toxicity data (one prescreened to be within the descriptor space and structural domain of the training set and the other to be outside the structural domain of the training set). For test set compounds inside the domain of the model, there was no relationship between absolute residue values for predictions and hydrophobicity; however, there was a linear relationship between absolute residue values and electrophilicity. It was concluded that predictivity in the region of the domain associated with higher electrophilicity, greater potency, and derivatives containing both halo- and nitro-groups is poorer than elsewhere in the domain, and therefore less confidence should be given to those values. Compounds in this region of the domain of the model are associated with the soft-, or pro-electrophilic mechanisms of toxic action. For the second test set, i.e., derivatives outside the structural domain, an examination of absolute residue values revealed that the observed toxicity is typically in excess of that predicted, especially for compounds in the structural space(s) of well-known electrophilic mechanisms of reactive toxicity. Caution is therefore urged in using statistical approaches to account for, and apply confidence to predictions from the applicability domain. An appreciation of the mechanism of toxicity appears to be critical to the determination of the most likely applicability domain.

QSAR & Combinatorial Science published new progress about Aquatic toxicity. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Han-Ming; Jia, Wen-Qiang; Liang, Zhi-Qin; Ye, Song published the artcile< N-Heterocyclic carbene-catalyzed [3+3] cyclocondensation of bromoenals and ketimines: highly enantioselective synthesis of dihydropyridinones>, Reference of 112-63-0, the main research area is benzoisothiazolopyridinone pyridinone dihydro enantioselective synthesis; enal bromo enantioselective cyclocondensation ketimine triazolium salt catalyst.

The N-heterocyclic carbene-catalyzed enantioselective [3+3] cyclocondensation of bromoenals and cyclic/acyclic ketimines gives the corresponding chiral dihydropyridinones I (R1 = n-Pr, Ph, 3-ClC6H4, 4-MeC6H4, etc.; R2 = H, n-Pr, Ph) and II (R1 = Ph, 4-ClC6H4, 2-MeOC6H4, etc.; R2 = H, Me; R3 = Ph, 2-ClC6H4, thiophen-2-yl, etc.) in high yields with high enantioselectivity.

Asian Journal of Organic Chemistry published new progress about Aldehydes, halo Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kasper, Karl; Abreu, Ilka N.; Feussner, Kirstin; Zienkiewicz, Krzysztof; Herrfurth, Cornelia; Ischebeck, Till; Janz, Dennis; Majcherczyk, Andrzej; Schmitt, Kerstin; Valerius, Oliver; Braus, Gerhard H.; Feussner, Ivo; Polle, Andrea published the artcile< Multi-omics analysis of xylem sap uncovers dynamic modulation of poplar defenses by ammonium and nitrate>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is ammonium nitrate xylem sap dynamic modulation multiomic analysis; carbohydrates; metabolomics; nitrogen; phytohormones; proteomics; salicinoids.

Xylem sap is the major transport route for nutrients from roots to shoots. In the present study, we investigated how variations in nitrogen (N) nutrition affected the metabolome and proteome of xylem sap and the growth of the xylem endophyte Brennaria salicis, and we also report transcriptional re-wiring of leaf defenses in poplar (Populus 3 canescens). We supplied poplars with high, intermediate or low concentrations of ammonium or nitrate. We identified 288 unique proteins in xylem sap. Approx. 85% of the xylem sap proteins were shared among ammonium- and nitrate-supplied plants. The number of proteins increased with increasing N supply but the major functional categories (catabolic processes, cell wallrelated enzymes, defense) were unaffected. Ammonium nutrition caused higher abundances of amino acids and carbohydrates, whereas nitrate caused higher malate levels in xylem sap. Pipecolic acid and N-hydroxypipecolic acid increased, whereas salicylic acid and jasmonoyl-isoleucine decreased, with increasing N nutrition. Untargeted metabolome analyses revealed 2179 features in xylem sap, of which 863 were differentially affected by N treatments. We identified 124 metabolites, mainly from specialized metabolism of the groups of salicinoids, phenylpropanoids, phenolics, flavonoids, and benzoates. Their abundances increased with decreasing N, except coumarins. Brennaria salicis growth was reduced in nutrient-supplemented xylem sap of low- and high- NO3–fed plants compared to that of NH4+-fed plants. The drastic changes in xylem sap composition caused massive changes in the transcriptional landscape of leaves and recruited defenses related to systemic acquired and induced systemic resistance. Our study uncovers unexpected complexity and variability of xylem composition with consequences for plant defenses.

Plant Journal published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Halloran, Matthew W.; Nicell, Jim A.; Leask, Richard L.; Maric, Milan published the artcile< Small molecule plasticizers for improved migration resistance: Investigation of branching and leaching behaviour in PVC blends>, Computed Properties of 112-63-0, the main research area is plasticizer PVC composite leaching mech thermal property.

The influence of branching on plasticizer effectiveness and migration behavior of heptyl-succinate plasticizers blended with poly(vinyl chloride) (PVC) was evaluated. An increase of branching led to a decrease in migration of the plasticizers into both hexanes and vegetable oil medias. Addnl., a quant. 1H NMR method was used to identify plasticizer concentration in the leachates and compared to a gravimetric standard test method. Overall, the quant. 1H NMR method proved to be a more direct method to assess leaching. In comparison to com. plasticizer di(2-ethylhexyl) phthalate (DEHP) and alternative plasticizer diheptyl succinate (DHPS), all of the branched species displayed superior migration resistance into hexanes (two to ten-fold). The glass transition temperatures and stress at break data indicated that the plasticizers comprised of up to three branches functioned as well as, or better than DEHP and DHPS. However, there was a decrease in plasticizer efficiency with compounds comprised of four or more branches.

Materials Today Communications published new progress about Elongation at break. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Meiorin, Cintia; Calvo-Correas, Tamara; Mosiewicki, Mirna Alejandra; Aranguren, Mirta Ines; Corcuera, Maria Angeles; Eceiza, Arantxa published the artcile< Comparative effects of two different crosslinkers on the properties of vegetable oil-based polyurethanes>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is crosslinked polyol based polyurethane comparative preparation property.

Thermoset polyurethanes (PUs) were prepared from a polyol derived from castor oil, 4,4′;-methylene di-Ph diisocyanate (MDI) and different trifunctional low-mol.-weight crosslinkers, biobased glycerol (Gly) and petroleum-derived trimethylolpropane (TMP). The synthesis was carried out in bulk and without catalyst via one-step polymerization varying the components equivalent weight ratio, Polyol:MDI:Gly and Polyol:MDI:TMP, resp. The physicochem., morphol., thermal, dynamic-mech., and mech. properties of the PUs were determined The success of the reaction between the polyol and MDI was confirmed by Fourier transform IR spectroscopy. The dynamic-mech. and the mech. properties as well as hardness were determined and related to the concentration of the low-mol.-weight crosslinkers utilized (Gly or TMP). However, important differences were observed between the synthesized two series, due to phase separation produced during the curing reaction, which affected more the materials prepared from TMP. SEM images and dynamic-mech. results confirmed this difference, related to the reactivity of primary and secondary hydroxyls present in the crosslinkers. Thermogravimetric anal. also showed to be sensible to the different structure of the crosslinkers with TMP leading to more thermally stable samples. Finally, measurements of water contact angle indicated that the surfaces were mostly hydrophobic with minor differences between the samples.

Journal of Applied Polymer Science published new progress about Complex modulus, tan δ. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Matsuzaki, Kei; Yamamoto, Iwao; Enomoto, Koji; Kaneko, Yutaro; Mimura, Tohru; Shiio, Tsuyoshi published the artcile< Synthesis of antitumor polysaccharides>, COA of Formula: C19H34O2, the main research area is antitumor polysaccharide preparation.

Previously, several antitumor polysaccharides having D-glucopyranose, D-mannopyranose, D-arabinofuranose, or its oligomer as side chains of (1→3)- β-glucan, or (1→4)-β-glucan were synthesized by the orthoester method as models of natural antitumor polysaccharides, such as lentinan, etc. Some of these have indicated high antitumor activity against sarcoma 180 implanted into mice, to the same extent as the natural polysaccharides. In this report, water soluble, branched polysaccharides having L-arabinofuranose or its oligomer, L-arabinopyranose, or D-galactopyranose as side chains were synthesized, and their structures and antitumor activities were determined, in order to investigate the effect of the kind of side chains on the antitumor activity. These synthetic polysaccharides showed high antitumor activity.

Polymer Science and Technology (Plenum) published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jagadeesh, Rajenahally V.; Surkus, Annette-Enrica; Junge, Henrik; Pohl, Marga-Martina; Radnik, Joerg; Rabeah, Jabor; Huan, Heming; Schuenemann, Volker; Brueckner, Angelika; Beller, Matthias published the artcile< Nanoscale Fe2O3-Based Catalysts for Selective Hydrogenation of Nitroarenes to Anilines>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is iron oxide catalyst nitroarene selective hydrogenation recycling.

Production of anilines-key intermediates for the fine chem., agrochem., and pharmaceutical industries relies on precious metal catalysts that selectively hydrogenate aryl nitro groups in the presence of other easily reducible functionalities. Herein, we report convenient and stable iron oxide (Fe2O3)-based catalysts as a more earth-abundant alternative for this transformation. Pyrolysis of iron-phenanthroline complexes on carbon furnishes a unique structure in which the active Fe2O3 particles are surrounded by a nitrogen-doped carbon layer. Highly selective hydrogenation of numerous structurally diverse nitroarenes (more than 80 examples) proceeded in good to excellent yield under industrially viable conditions.

Science (Washington, DC, United States) published new progress about Aromatic nitro compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Qiang; Tang, Xiang-Ying; Shi, Min published the artcile< Metal-Free Cross-Coupling of Arylboronic Acids and Derivatives with DAST-Type Reagents for Direct Access to Diverse Aromatic Sulfinamides and Sulfonamides>, Reference of 112-63-0, the main research area is aromatic sulfinamide sulfonamide preparation; arylboronic acid ester aminosulfur trifluoride cross coupling; arylboronic acids; cross-coupling; sulfinamides; sulfonamides; synthetic methods.

We have developed a simple and convenient method for the cross-coupling of arylboronic acids and their derivatives with DAST-type reagents under mild and metal-free conditions to directly afford sulfinamides in moderate to good yields. Moreover, sulfonamides were obtained after a simple oxidation reaction. The reaction mechanism was investigated by 18O-labeling experiments, and the synthetic utility was demonstrated by the sulfoxidation of natural products.

Angewandte Chemie, International Edition published new progress about Arenesulfonamides Role: SPN (Synthetic Preparation), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics