Category: 112-63-0

Labbe, Gerrit; Sannen, Ingrid; Dehaen, Wim published the artcile< Synthesis of fused dihydro-1,2,4-thiadiazolimines from cyano-substituted azides and acyl isothiocyanates>, Reference of 112-63-0, the main research area is fused hydrothiadiazolimine; cyano substituted azide cycloaddition acyl isothiocyanate; mechanism cycloaddition acyl isothiocyanate.

Organic azides, bearing a nitrile function at the γ- or δ-position, react with acyl isothiocyanates to give fused dihydro-1,2,4-thiadiazolimines. Representative examples are given. In the case of 2-NCC6H4CH2N3 and BzNCS, the formation of I is accompanied by two side products, II and III. Mechanisms are presented to explain the formation of the products.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Azides Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jagleniec, Damian; Wilczek, Marcin; Romanski, Jan published the artcile< Tripodal, squaramide-based ion pair receptor for effective extraction of sulfate salt>, Computed Properties of 112-63-0, the main research area is tripodal squaramide based ion pair receptor preparation; ion pair receptors; squaramide; sulfate extraction; tripodal receptors.

Combining three features-the high affinity of squaramides toward anions, cooperation in ion pair binding and preorganization of the binding domains in the tripodal platform-led to the effective receptor I [R1R2 = O(CH2CH2O)5]. The lack of at least one of these key elements caused a lower affinity toward ion pairs. Receptor I [R1R2 = O(CH2CH2O)5] was found to form an intramol. network in wet chloroform, which changed into inorganic-organic associates after contact with ions and allowed salts to be extracted from an aqueous to an organic phase. The disparity in the binding mode of I [R1R2 = O(CH2CH2O)5] with sulfates and with other monovalent anions led to the selective extraction of extremely hydrated sulfate anions in the presence of more lipophilic salts, thus overcoming the Hofmeister series.

Molecules published new progress about Crown ethers Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Desch, Karl Heinz published the artcile< Fungicide finishing of synthetic fabrics>, Application In Synthesis of 112-63-0, the main research area is Antibac MF fungicide synthetic fiber; benzimidazolecarbamic acid methyl ester fungicide; acrylic fiber fungicide.

The fungicidal finishing of acrylic awnings with Antibac MF (I) [5805-53-8], a benzimidazolecarbamic acid Me ester, is described. The oral toxicity of I is low and I controls a wide variety of fungi. Fungicidal compositions containing I are durable and weather-resistant.

Deutscher Faerber-Kalender published new progress about Acrylic fibers Role: USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application In Synthesis of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gloaguen, Celine; Voisin-Chiret, Anne Sophie; Sopkova-de Oliveira Santos, Jana; Fogha, Jade; Gautier, Fabien; De Giorgi, Marcella; Burzicki, Gregory; Perato, Serge; Petigny-Lechartier, Cecile; Simonin-Le Jeune, Karin; Brotin, Emilie; Goux, Didier; N’Diaye, Monique; Lambert, Bernard; Louis, Marie-Helene; Ligat, Laetitia; Lopez, Frederic; Juin, Philippe; Bureau, Ronan; Rault, Sylvain; Poulain, Laurent published the artcile< First Evidence That Oligopyridines, α-Helix Foldamers, Inhibit Mcl-1 and Sensitize Ovarian Carcinoma Cells to Bcl-xL-Targeting Strategies>, Related Products of 112-63-0, the main research area is oligopyridine preparation Mcl1 ovary cancer sensitization BclxL siRNA.

Apoptosis control defects such as the deregulation of Bcl-2 family member expression are frequently involved in chemoresistance. In ovarian carcinoma, we previously demonstrated that Bcl-xL and Mcl-1 cooperate to protect cancer cells against apoptosis and their concomitant inhibition leads to massive apoptosis even in the absence of chemotherapy. Whereas Bcl-xL inhibitors are now available, Mcl-1 inhibition, required to sensitize cells to Bcl-xL-targeting strategies, remains problematic. In this context, we designed and synthesized oligopyridines potentially targeting the Mcl-1 hydrophobic pocket, evaluated their capacity to inhibit Mcl-1 in live cells, and implemented a functional screening assay to evaluate their ability to sensitize ovarian carcinoma cells to Bcl-xL-targeting strategies. We established structure-activity relationships and focused our attention on MR29072, named Pyridoclax. Surface plasmon resonance assay demonstrated that pyridoclax directly binds to Mcl-1. Without cytotoxic activity when administered as a single agent, pyridoclax induced apoptosis in combination with Bcl-xL-targeting siRNA or with ABT-737 in ovarian, lung, and mesothelioma cancer cells.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Related Products of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fu, Yu; Van Oosterwijck, Chantal; Vandendriessche, Annelies; Kowalczuk-Bleja, Agnieszka; Zhang, Xi; Dworak, Andrzej; Dehaen, Wim; Smet, Mario published the artcile< Hyperbranched Poly(arylene oxindole)s with a Degree of Branching of 100% for the Construction of Nanocontainers by Orthogonal Modification>, Computed Properties of 112-63-0, the main research area is polycondensation hyperbranched polyarylene oxindole synthesis functionalization modification; functionalized hyperbranched polyarylene oxindole hydrophobic hydrophilic dye encapsulation.

Hyperbranched polymers with a degree of branching of 100% were prepared and converted into different types of unimol. micelle-like structures. The polymers were obtained by acid catalyzed polycondensation of an isatin-based AB2 monomer, prepared without using toxic organometal reagents or extensive chromatog. purification The molar masses as determined by SEC relative to linear PS standards were strongly underestimated as compared to absolute data determined by MALLS. This could be accounted for by the densely branched structure and the formation of intramol. hydrogen bonds. The hyperbranched scaffolds were converted into unimol. micelle-like structures in two ways. In a first approach, long alkyl chains were introduced at the terminal units and carboxyl groups at the dendritic units. The resulting macromols. were soluble in apolar solvents and able to bind polar dyes. Alternatively, the terminal units could be converted into quaternary ammonium salts, leading to water-soluble macromols. binding apolar BODIPY dyes.

Macromolecules (Washington, DC, United States) published new progress about Branched polymers, hyperbranched dendritic polymers Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), PROC (Process), PREP (Preparation) (aromatic polyether-polyketone-, oxindole-containing). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Computed Properties of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Xuerui; Yin, Zequn; Cao, Peichang; Zheng, Shihong; Chen, Yuanli; Yu, Maoyun; Liao, Chenzhong; Zhang, Zhongyuan; Duan, Yajun; Han, Jihong; Zhang, Shuang; Yang, Xiaoxiao published the artcile< NaoXinTong Capsule ameliorates memory deficit in APP/PS1 mice by regulating inflammatory cytokines>, COA of Formula: C19H34O2, the main research area is NaoXinTong capsule ameliorate memory deficit regulating inflammatory cytokine; Alzheimer’s disease; Apoptosis; Cognitive impairment; NaoXinTong Capsule; Neuroinflammation.

Alzheimer’ s disease (AD) is the most common neurodegenerative disease in aging population. Neuroinflammation, hyperphosphorylated Tau (p-Tau) and the imbalance between production and clearance of β-amyloid peptide (Aβ) are the major causes for AD development. NaoXinTong Capsule (NXT), a traditional Chinese medicine, is wildly used for treatment of cardiovascular and cerebrovascular diseases. Hence, we used the double transgenic mice expressing chimeric human amyloid precursor protein and mutant human presenilin 1 (APP/PS1) and HT-22 cells to determine the neuroprotective effects of NXT in AD development and the involved mechanisms. The 3-mo-old APP/PS1 mice were randomly divided into 3 groups and received following treatment: Control group, mice were fed normal chow; NXT groups, mice were fed normal chow containing NXT at a normal and a high dose, resp. While the age-matched C57BL/6J mice fed normal chow were used as the normal control. The NXT treatment was lasted for 5 mo. We found that NXT treatment improved spatial memory impairment and cognitive decline in APP/PS1 mice by decreasing p-Tau levels and Aβ accumulation in the brain. Mechanistically, we observed that NXT inhibited neuron atrophy and apoptosis by downregulating inflammatory cytokines, interleukin 1β (IL-1β), IL-6 and tumor necrosis factor α (TNF-α), and inflammation mediators, nuclear factor κB (NF-κB) and toll-like receptor 4 (TLR4) in the brain. Consistently, NXT blocked L-glutamic acid-induced reactive oxygen species production, inflammation and apoptosis in HT-22 cells partially by inhibiting TLR4/NF-κB/IL-1β signaling pathway. Our study demonstrates that NXT ameliorates AD by reducing p-Tau, Aβ accumulation, inflammation and neuron apoptosis via regulation of TLR4-mediated inflammatory system. It also suggests the potential application of NXT for AD treatment.

Biomedicine & Pharmacotherapy published new progress about Achyranthes bidentata. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lokman NolHakim, Muhammad Amirrul Hakim; Shohaimi, Norshahidatul Akmar Mohd; Mokhtar, Wan Nur Aini Wan; Ibrahim, Mohd Lokman; Abdullah, Rose Fadzilah published the artcile< Immobilization of Potassium-Based Heterogeneous Catalyst over Alumina Beads and Powder Support in the Transesterification of Waste Cooking Oil>, Formula: C19H34O2, the main research area is immobilization potassium heterogeneous catalyst alumina transesterification waste cooking oil.

In this work, the beads and powder potassium hydroxide (KOH) and potassium carbonate (K2CO3) supported on alumina oxide (Al2O3) were successfully prepared via incipient wetness impregnation technique. Herein, the perforated hydrophilic materials (PHM) made from low-d. polyethylene (LDPE) was used as the catalyst reactor bed. The prepared catalysts were investigated using TGA, XRD, BET, SEM-EDX, TPD, FTIR while spent catalysts were analyzed using XRF and ICP-AES to study its deactivation mechanism. The catalytic performance of beads and powder KOH/Al2O3 and K2CO3/Al2O3 catalysts were evaluated via transesterification of waste cooking oil (WCO) to biodiesel. It was found that the optimum conditions for transesterification reaction were 1:12 of oil-to-methanol molar ratio and 5 weight% of catalyst at 65°C. As a result, the mesoporous size of beads KOH/Al2O3 and K2CO3/Al2O3 catalysts yielded 86.8% and 77.3% at 2 h’ reaction time of fatty acids Me ester (FAME), resp. It was revealed that the utilization of PHM for beads K2CO3/Al2O3 increase the reusability of the catalyst up to 7 cycles. Furthermore, the FAME produced was confirmed by the gas chromatog.-mass spectroscopic technique. From this finding, beads KOH/Al2O3 and K2CO3/Al2O3 catalysts showed a promising performance to convert WCO to FAME or known as biodiesel.

Catalysts published new progress about Adsorption. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Huifang; Lu, Qun; Liu, Rui published the artcile< Widely targeted metabolomics analysis reveals the effect of fermentation on the chemical composition of bee pollen>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is metabolomics analysis fermentation chem composition bee pollen; Bee pollen; Differential metabolites analysis; ESI-Q-TRAP-MS/MS; Fermentation; Phenolamides.

Microbial fermentation can break the bee pollen wall. However, the global profiling of bee pollen metabolites under fermentation remains unclear. This study aims to comprehensively elucidate the changes in the composition of bee pollen after microbial fermentation Ultra-performance liquid chromatog.-electron spray ionization-mass spectrometry (UPLC-ESI-MS) based on widely targeted metabolomics anal. was used to compare the chem. composition of unfermented bee pollen (UBP) and fermented bee pollen (FBP). Among the 890 metabolites detected, a total of 668 differential metabolites (classified into 17 categories) were identified between UBP and FBP. Fermentation significantly increased the contents of primary metabolites such as 74 amino acids and derivatives, 42 polyunsaturated fatty acids and 66 organic acids, as well as some secondary metabolites such as 38 phenolic acids, 80 flavone aglycons and 22 phenolamides. The results indicate that fermentation is a promising strategy to improve the nutritional value of bee pollen.

Food Chemistry published new progress about Aglycons Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yan, Bin; Han, Dehui; Boissiere, Olivier; Ayotte, Patrick; Zhao, Yue published the artcile< Manipulation of block copolymer vesicles using CO2: dissociation or ""breathing"">, Reference of 112-63-0, the main research area is diblock copolymer vesicle carbon dioxide dissociation swelling.

We demonstrate a general way to prepare CO2-responsive block copolymer (BCP) vesicles by employing poly(N,N’-diethylaminoethylmethacrylate) (PDEAEMA) as the hydrophobic block. Two amphiphilic BCPs containing either poly(N,N’-dimethylacrylamide) (PDMA) or poly(ethylene oxide) (PEO) as the hydrophilic block and either PDEAEMA or P(DEAEMA-co-CMA) (photo-crosslinkable PDEAEMA containing a number of coumarin side groups) as the hydrophobic block were synthesized and used to prepare vesicles in aqueous solutions These vesicles exhibit very good responsiveness to gas stimuli. On the one hand, upon CO2 bubbling, PDMA-b-PDEAEMA vesicles display morphol. changes that range from expansion to complete dissociation, which is thought to be determined by the protonation degree of the DEAEMA unit in the vesicle membrane. On the other hand, PEO-b-P(DEAEMA-co-CMA) vesicles whose membrane is crosslinked through coumarin dimerization can undergo reversible expansion and contraction under alternating passage of CO2 and argon (Ar) in solution; the extent of such vesicle “”breathing”” can be controlled by adjusting the degree of dimerization of coumarin within the vesicle membrane. Finally, pyrene-1,3,6,8-tetrasulfonic acid tetrasodium salt was used as a model drug, allowing its CO2-controllable release from these two vesicle types to be investigated.

Soft Matter published new progress about Dimerization (of coumarin-containing block). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pazy, Yael; Raboy, Bilha; Matto, Meirav; Bayer, Edward A.; Wilchek, Meir; Livnah, Oded published the artcile< Structure-based rational design of streptavidin mutants with pseudo-catalytic activity>, Application of C19H34O2, the main research area is design streptavidin hydrolysis catalyst.

Introduction of enzymic activity into proteins or other types of polymers by rational design is a major objective in the life sciences. To date, relatively low levels of enzymic activity could be introduced into antibodies by using transition-state analogs of haptens. In the present study, the authors identify the structural elements that contribute to the observed hydrolytic activity in egg white avidin, which promote the cleavage of active biotin esters (notably biotinyl p-nitrophenyl ester). The latter elements were then incorporated into bacterial streptavidin via genetic engineering. The streptavidin mol. was thus converted from a protector to an enhancer of hydrolysis of biotin esters. The conversion was accomplished by the combined replacement of a “”lid-like loop”” (L3,4) and a leucine-to-arginine point mutation in streptavidin. Interestingly, neither of these elements play a direct role in the hydrolytic reaction. The latter features were thus shown to be responsible for enhanced substrate hydrolysis. This work indicates that structural and noncatalytic elements of a protein can be modified to promote the induced fit of a substrate for subsequent interaction with either a catalytic residue or water mols. This approach complements the conventional design of active sites that involves direct modifications of catalytic residues.

Journal of Biological Chemistry published new progress about Avidins Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics