Category: 112-63-0

Yang, Eryan; Wang, Lin; Jin, Weili; Liu, Xing; Wang, Qixue; Wu, Ye; Tan, Yanli; Wang, Yunfei; Cui, Xiaoteng; Zhao, Jixing; Tong, Fei; Hong, Biao; Xiao, Menglin; Liu, Xiaomin; Fang, Chuan; Kang, Chunsheng published the artcile< PTRF/Cavin-1 enhances chemo-resistance and promotes temozolomide efflux through extracellular vesicles in glioblastoma>, Reference of 112-63-0, the main research area is temozolomide glioblastoma chemoresistance extracellular vesicle PTRF cavin; Glioblastoma; PTRF; chloroquine; extracellular vesicles; temozolomide.

The concentration and duration of intracellular drugs have always been the key factors for determining the efficacy of the treatment. Efflux of chemotherapeutic drugs or anticancer agents is a major reason for multidrug resistance generation in cancer cells. The high expression of polymerase I and transcript release factor (PTRF) is correlated with a worse prognosis in glioma patients. However, the importance of PTRF on temozolomide (TMZ) resistance in glioblastoma (GBM) is poorly understood. TCGA data anal., CGGA data anal., transmission electron microscopy (TEM), SEM (SEM), clone formation, cell counting kit-8 (cck-8), western blot (WB), immunofluorescence (IF), immunohistochem. (IHC) and flow cytometry assays were performed to investigate the underlying mechanism and effect of PTRF on TMZ-resistance in a variety of GBM cell lines and GBM patient-derived xenograft (PDX) models. Clone formation, WB, IF, IHC and flow cytometry assays were performed to examine the efficacy of sequential therapy of TMZ followed by CQ in GBM cells and PDX models. The prognosis of GBM patients treated with TMZ was neg. correlated with PTRF expression. Our results reveal that PTRF knockdown significantly decrease proliferation and increase apoptosis in GBM after TMZ treatment. Moreover, PTRF contribute to TMZ-resistance by increasing TMZ efflux through extracellular vesicles (EVs). Furthermore, our results demonstrate that sequential therapy of TMZ followed by CQ significantly promotes the TMZ efficacy against GBM by increasing intracellular TMZ concentration ([TMZ]i). This study highlights that PTRF can act as an independent biomarker to predict the prognosis of GBM patients after TMZ treatment and describes a new mechanism contributing to TMZ-resistance. In addition, this study may provide a novel idea for GBM therapy.

Theranostics published new progress about Animal gene Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (Bax). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gagneux, A.; Grob, C. A. published the artcile< Bicyclo[2.2.2]octane series. III. Structure and solvolysis of bicyclo[2.2.2]octa-2,5-diene dibromides>, HPLC of Formula: 112-63-0, the main research area is .

Bromination of bicyclo[2.2.2]octa-2,5-diene (I) led to a mixture of trans- 3,5-dibromohomotricyclene (II) and trans- 2,3-dibromobicyclo[2.2.2]oct-5-ene (III) in the ratio of 3:7. The result was explained as the endo addition of Br to I. Hydrolysis of III yielded 8-bromobicyclo[3.2.1]oct-2-en-4-ol by ionization of the endo Br atom. The rate of solvolysis was 143 times that of cyclopentyl bromide. Similarly, II solvolyzed 384 times as fast as cyclopentyl bromide did. This suggested participation of the strained cyclopropane ring in the ionization step.

Helvetica Chimica Acta published new progress about Bromination. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yuan, Dan; Liu, Meijing; Jia, Peng; Li, Yiping; Huang, Yuling; Ye, Li; Api, Laze; Chen, Maogang; Yao, Liang; Wang, Zixin; Liu, Honglu; Liang, Shu; Yang, Shujuan published the artcile< Prevalence and determinants of virological failure, genetic diversity and drug resistance among people living with HIV in a minority area in China: a population-based study>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is HIV virol failure genetic diversity drug resistance China; Antiretroviral therapy; Drug resistance; HIV; HIV-1 subtypes; Virological failure.

Liangshan Yi Autonomous Prefecture is one of the areas that most severely affected by human immunodeficiency virus (HIV) in China, and virol. failure on antiretroviral therapy (ART) is serious in this area. Anal. of prevalence and determinants of ART failure, the genetic diversity and drug resistance among people living with HIV (PLWH) helps improve HIV treatment efficiency and prevent HIV transmission. A total of 5157 PLWH were recruited from 2016 to 2017. The venous blood samples were subjected to RT-PCR, followed by sequencing of the HIV-1 pol gene, targeting the protease and reverse transcriptase fragments. HIV-1 diversity was analyzed using the DNAStar software and drug resistance mutations were analyzed using the Stanford University HIV Drug Resistance Database. A total of 2156 (41.81%) PLWH showed virol. failure on ART. Males (ORm = 1.25), heterosexual behaviors and drug injection (ORm = 1.44) and mother to child transmission routes (ORm = 1.58), the clin. stage of AIDS (ORm = 1.35), having used illicit drugs and shared the needles (1-4 times: ORm = 1.34; more than 5 times: ORm = 1.52), having ever replaced ART regimen (ORm = 1.48) increased the risk of virol. failure among PLWH, while higher education lever (ORm = 0.77) and ≥ 12 mo on ART (12 ∼ 36 mo: ORm = 0.72; ≥36 mo: ORm = 0.66) was associated with lower likelihood of virol. failure. The data revealed that CRF07_BC (1508, 95.62%) were the most common strains, and the drug-resistant rate was 32.10% among PLWH with virol. failure in this area. The high frequencies of drug resistance were found in EFV and NVP of NNRTIs, ABC, FTC and 3TC of NRTIs, and TPV/r in PIs. The most common mutations in NNRTIs, NRTIs and PIs were K103N/KN (64.69%), M184V/MV/I (36.29%) and Q58E/QE (4.93%), resp. We concluded that surveillance of virol. failure, HIV-1 subtypes, and drug resistance to understand HIV-1 epidemiol. and guide modification of ART guidelines, and target prevention and control strategies should be formatted to reduce the virol. failure and drug resistance to promote viral suppression and prevent HIV-1 transmission.

BMC Infectious Diseases published new progress about AIDS (disease). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fuentes Pineda, Rosinda; Zems, Yaroslav; Troughton, Joel; Niazi, Muhammad R.; Perepichka, Dmitrii F.; Watson, Trystan; Robertson, Neil published the artcile< Star-shaped triarylamine-based hole-transport materials in perovskite solar cells>, Category: esters-buliding-blocks, the main research area is triarylamine hole transport material perovskite solar cell.

Two novel star-shaped triarylamine-based hole transport materials with triphenylamine (STR1), or a partially oxygen-bridged triphenylamine (STR0), as core and para-substituted triphenylamine side arms were synthesized, fully characterized and studied in perovskite solar cells. Their thermal, optical, electrochem. and charge transport properties were examined and compared in the context of their mol. structure. Due to its more planar configuration, STR0 showed a red-shifted absorption in comparison with STR1. STR0 also forms a more stable amorphous glassy state and showed higher glass transition temperature than STR1 and spiro-OMeTAD. These HTMs were tested in perovskite solar cells using a device configuration of FTO/bl-TiO2/mp-TiO2/CH3NH3PbI3/HTM/Au showing a power conversion efficiency of 13.3% for STR0 and 11.5% for STR1. The STR0-based devices showed higher fill factor and better reproducibility than spiro-OMeTAD-based cells. Without dopant additives, solar cells based on STR0 exhibited a good photocurrent d. of 16.63 mA cm-2 and the efficiency improved from a starting PCE of 3.9% to 6.6% after two weeks of storage.

Sustainable Energy & Fuels published new progress about Band gap Role: PRP (Properties), TEM (Technical or Engineered Material Use), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Castro, Gabriel Abranches Dias; Fernandes, Sergio Antonio published the artcile< Microwave-assisted green synthesis of levulinate esters as biofuel precursors using calix[4]arene as an organocatalyst under solvent-free conditions>, Reference of 112-63-0, the main research area is levulinate ester sulfonic acid calixarene organocatalyst microwave green synthesis.

Levulinic acid, one of the top 12 value-added chems., can be obtained by the transformation of biomass by acid catalysis. Alkyl levulinate has been widely explored as a precursor for obtaining renewable fuel additives. In this work, the organocatalyst CX4SO3H was employed for the first time as an organocatalyst for levulinic acid esterification reactions. Various parameters, such as the temperature, reaction time, and catalyst load, were investigated. The optimized reaction conditions were a reaction temperature of 80°C (MWI), a reaction time of 2.5 min, a CX4SO3H catalyst load of 1 mol% and solvent-free conditions. Ten different alcs. were evaluated for the synthesis of alkyl levulinate with high yields (ca. 99%), with the exception of tert-Bu alc. (13% yield). The levulinic acid esterification reaction, a type of green chem. reaction, has many advantages such as (i) creation of a new C-O bonds, (ii) water being the sole waste, (iii) 100% carbon economy, (iv) metal- and solvent-free processes, (v) short time and (vi) nontoxic and reusable organocatalysts. These advantages, along with the simple workup procedure, make this efficient protocol a greener alternative to the traditional methods used for the synthesis of levulinate esters to generate biofuels.

Sustainable Energy & Fuels published new progress about Green chemistry. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Rzhevskiy, Sergey A.; Topchiy, Maxim A.; Golenko, Yulia D.; Gribanov, Pavel S.; Sterligov, Grigorii K.; Kirilenko, Nikita Yu.; Ageshina, Alexandra A.; Bermeshev, Maxim V.; Nechaev, Mikhail S.; Asachenko, Andrey F. published the artcile< Undirected ortho-selectivity in C-H borylation of arenes catalyzed by NHC platinum(0) complexes>, Application of C19H34O2, the main research area is regioselective borylation arene platinum NHC complex catalyst.

Borylation of arenes with bis(pinacolato)diboron catalyzed by sterically encumbered NHC platinum complexes proceeds predominantly at ortho-position even in the absence of a directing group (o : m : p ratio up to 10: 3: 1). The similar borylation with pinacolborane would proceed less selectively.

Mendeleev Communications published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Application of C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fernandez-Alvarez, Ana J.; Thomas, Maria Gabriela; Pascual, Malena L.; Habif, Martin; Pimentel, Jeronimo; Corbat, Agustin A.; Pessoa, Joao P.; La Spina, Pablo E.; Boscaglia, Lara; Plessis, Anne; Carmo-Fonseca, Maria; Grecco, Hernan E.; Casado, Marta; Boccaccio, Graciela L. published the artcile< Smaug1 membrane-less organelles respond to AMPK and mTOR and affect mitochondrial function>, Category: esters-buliding-blocks, the main research area is smaug membrane less organelle AMPK mTOR affect mitochondrial function; AMPK; Membrane-less organelles; Metformin; Mitochondria; Processing bodies; Smaug; UQCRC1.

Smaug is a conserved translational regulator that binds numerous mRNAs, including nuclear transcripts that encode mitochondrial enzymes. Smaug orthologs form cytosolic membrane-less organelles (MLOs) in several organisms and cell types. We have performed single-mol. fluorescence in situ hybridization (FISH) assays that revealed that SDHB and UQCRC1 mRNAs associate with Smaug1 bodies in U2OS cells. Loss of function of Smaug1 and Smaug2 (also known as SAMD4A and SAMD4B, resp.) affected both mitochondrial respiration and morphol. of the mitochondrial network. Phenotype rescue by Smaug1 transfection depends on the presence of its RNA-binding domain. Moreover, we identified specific Smaug1 domains involved in MLO formation, and found that impaired Smaug1 MLO condensation correlates with mitochondrial defects. Mitochondrial complex I inhibition upon exposure to rotenone, but not strong mitochondrial uncoupling upon exposure to CCCP, rapidly induced the dissolution of Smaug1 MLOs. Metformin and rapamycin elicited similar effects, which were blocked by pharmacol. inhibition of AMP-activated protein kinase (AMPK). Finally, we found that Smaug1 MLO dissolution weakens the interaction with target mRNAs, thus enabling their release. We propose that mitochondrial respiration and the AMPK-mTOR balance controls the condensation and dissolution of Smaug1 MLOs, thus regulating nuclear mRNAs that encode key mitochondrial proteins.

Journal of Cell Science published new progress about Cell morphology. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Murphy, Nicie Conley; Compton, Robert N.; Pagni, Richard M. published the artcile< Effect of Chiral and Achiral Perturbations on the Crystallization of 4,4'-Dimethylchalcone from Ethyl Acetate>, HPLC of Formula: 112-63-0, the main research area is beta radiolysis polarized light effect crystallization methylchalcone; optical activity achiral mol manipulation synthetic photochem method; chiral achiral perturbation effect crystallization methylchalcone Et acetate.

4,4′-Dimethylchalcone is an achiral mol. that crystallizes from Et acetate in the chiral space group P212121. The authors report the effect of β-radiolysis and circularly and linearly polarized light on the crystallization of 4,4′-dimethylchalcone from Et acetate. Exposure of the evaporating solution to energetic β-particles from a Sr-90 source generated a random distribution of (+) and (-) crystals. Irradiation of the evaporating solution by intense right- or left-circularly polarized light (1064 nm) from a Nd:YAG laser afforded results that were comparable to the results of the β-radiolysis experiments Linearly polarized light (LPL), on the other hand, had a profound influence on the distribution of crystals, yielding in this instance a large bifurcation of (+) and (-) crystals. A likely cause of this outcome may be due to the optical Kerr effect. The anisotropic polarizability of the chalcone mol. causes a preferential alignment in the direction of the E field when using LPL. This mol. alignment results in a sizable enantiomeric excess. Circularly polarized light does not produce the alignment of the chalcone and thus has no effect on the asym. induction. This alignment offers an opportunity for chirally autocatalytic secondary nucleation to occur, which is then able to amplify small initial asymmetry in the number of (+) and (-) crystals. The chirality of the chalcone crystals was determined via their reaction in water with pyridinium tribromide to yield the chiral compound erythro-1,2-dibromo-4,4′-dimethylchalcone, thus allowing the chirality of the crystal to be propagated to mol. chirality.

Crystal Growth & Design published new progress about Chirality. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, HPLC of Formula: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Yan; Kong, Xiao; Yang, Xiaoyin; Zhu, Lixian; Liang, Rongrong; Luo, Xin; Zhang, Liang; Hopkins, David L.; Mao, Yanwei; Zhang, Yimin published the artcile< Effect of energy metabolism and proteolysis on the toughness of intermediate ultimate pH beef>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is longissimus lumborum beef energy metabolism toughness pH; Beef; Intermediate pH(u); Targeted metabolomics; Tenderness.

The objective of this study was to identify the tenderness and energy metabolism attributes in normal ultimate pH (pHu, 5.4-5.8, NpHu), intermediate pHu (5.8-6.2, IpHu) and high pHu (> 6.2, HpHu) Longissimus lumborum from beef. During 21 days of aging, the IpHu group exhibited a higher Warner-Bratzler shear force, lower activity of μ-calpain, and a higher content of heat shock protein 27 and greater protein oxidation Metabolomics anal. revealed that 24 differential metabolites were detected during the first 24 h postmortem between pH groups, and these were mainly the products of glycolysis, the tricarboxylic acid (TCA) cycle and oxidative phosphorylation. The relatively higher ATP content in the IpHu group could delay tenderization by being used as key substrate for protein phosphorylation. In addition, the relationship between guanosine triphosphate, diphosphate and monophosphate, and beef tenderness was worthy to be verified in the future study.

Meat Science published new progress about Beef. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nagashima, Yuki; Takita, Ryo; Yoshida, Kengo; Hirano, Keiichi; Uchiyama, Masanobu published the artcile< Design, Generation, and Synthetic Application of Borylzincate: Borylation of Aryl Halides and Borylzincation of Benzynes/Terminal Alkyne>, Electric Literature of 112-63-0, the main research area is borylzincate formation mol structure calculation; borylation aryl halide borylzincation benzyne terminal alkyne; zinc catalyzed borylation aryl halide.

Borylzincate was generated in situ from dialkylzinc, diboron, and metal alkoxide. Model DFT calculations showed that although the formation of boryl-zinc-ate is kinetically favorable, it is thermodynamically unfavorable. Therefore, we designed a successive reaction sequence that would provide a compensating energy gain. This enabled Zn-catalyzed borylation of aryl halides and boryl-zincation of benzynes and terminal alkyne from diborons without the need for any cocatalyst.

Journal of the American Chemical Society published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Electric Literature of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics