Category: 112-63-0

Garcia, Catherine R.; Myint, Zin W.; Jayswal, Rani; Wang, Chi; Morgan, Rachael M.; Butts, Allison R.; Weiss, Heidi L.; Villano, John L. published the artcile< Hematological adverse events in the management of glioblastoma>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is hematol adverse event management glioblastoma; Bevacizumab; Glioblastoma; Hematologic adverse events; Management; Outcomes; Temozolomide.

Hematol. adverse events (HAEs) are common during treatment for glioblastoma (GBM), usually associated with temozolomide (TMZ). Their clin. value is uncertain, as few investigations have focused on outcomes for HAEs during GBM treatment. We combined data from two randomized clin. trials, RTOG 0525 and RTOG 0825, to analyze HAEs during treatment for GBM. We investigated differences between chemoradiation and adjuvant therapy, and by regimen received during adjuvant treatment. 1454 Patients participated in these trials, of which 1154 (79.4%) developed HAEs. During chemoradiation, 44.4% of patients developed HAEs (54% involving more than one cell line), and were most commonly lymphopenia (50.6%), and thrombocytopenia (47.5%). During adjuvant treatment, 45% of patients presented HAEs (78.6% involving more than one cell line), and were more commonly leukopenia (62.7%), and thrombocytopenia (62.3%). Median overall survival (OS) and progression free survival (PFS) were longer in patients with HAEs (OS 19.4 mo and PFS 9.9 mo) compared to those with other or no adverse events (OS 14.1 mo and PFS 5.9 mo). There was no significant difference in survival between grade 1 and/or 2 vs. grade 3 and/or 4 HAEs. History of HAEs during chemoradiation was a protective factor for presentation of HAEs during adjuvant therapy. HAEs are common during GBM treatment, and often involve more than one cell line (more likely during adjuvant therapy). HAEs may be associated with prolonged OS and PFS, particularly during adjuvant therapy. HAEs during chemoradiation was a protective factor for HAEs during adjuvant therapy.

Journal of Neuro-Oncology published new progress about Age groups. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Collett, Christopher J.; Young, Claire M.; Massey, Richard S.; O’Donoghue, AnnMarie C.; Smith, Andrew D. published the artcile< Kinetic and Structure-Activity Studies of the Triazolium Ion- Catalyzed Intramolecular Stetter Reaction>, Reference of 112-63-0, the main research area is ethyl formylphenoxy butenoate heterocyclic carbene Stetter reaction mechanism kinetics.

Mechanistic studies of the triazolium ion-catalyzed intramol. Stetter reaction using initial rates anal. in NEt3/NEt3 · HCl buffered methanol showed the reaction to be first-order in catalyst and zero-order in aldehyde over a broad range of aldehyde concentrations The observed reaction rate is higher for catalysts bearing N-aryl substituents with electron-withdrawing groups. A concurrent, NHC-independent substrate isomerization was also observed and found to demonstrate a first-order dependence on aldehyde concentration The reported data are consistent with deprotonation to form the Breslow intermediate being turnover-limiting in this process.

European Journal of Organic Chemistry published new progress about Cis-trans isomerization. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Reference of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Makida, Yusuke; Saita, Masahiro; Kuramoto, Takahiro; Ishizuka, Kentaro; Kuwano, Ryoichi published the artcile< Asymmetric Hydrogenation of Azaindoles: Chemo- and Enantioselective Reduction of Fused Aromatic Ring Systems Consisting of Two Heteroarenes>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is enantioselective hydrogenation azaindole ruthenium phosphine catalyst; asymmetric catalysis; azaindoles; chemoselectivity; hydrogenation; ruthenium.

High enantioselectivity was achieved for the hydrogenation of azaindoles by using the chiral catalyst, which was prepared from [Ru(η3-methallyl)2(cod)] and a trans-chelating bis(phosphine) ligand (PhTRAP). The dearomative reaction exclusively occurred on the five-membered ring, thus giving the corresponding azaindolines with up to 97:3 enantiomer ratio.

Angewandte Chemie, International Edition published new progress about Enantioselective synthesis. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Choi-Sledeski, Yong Mi; Kearney, Robert; Poli, Gregory; Pauls, Henry; Gardner, Charles; Gong, Yong; Becker, Michael; Davis, Roderick; Spada, Alfred; Liang, Guyan; Chu, Valeria; Brown, Karen; Collussi, Dennis; Leadley, Robert Jr.; Rebello, Sam; Moxey, Phillip; Morgan, Suzanne; Bentley, Ross; Kasiewski, Charles; Maignan, Sebastien; Guilloteau, Jean-Pierre; Mikol, Vincent published the artcile< Discovery of an orally efficacious inhibitor of coagulation factor Xa which incorporates a neutral P1 ligand>, Category: esters-buliding-blocks, the main research area is ketopiperazino methylazaindole factor Xa inhibitor structure thrombolytic.

The discovery and SAR of ketopiperazino methylazaindole factor Xa inhibitors are described. Structure-activity data suggesting that this class of inhibitors does not bind in the canonical mode were confirmed by an X-ray crystal structure showing the neutral haloarom. bound in the S1 subsite. The most potent azaindole (I, RPR209685) is selective against related serine proteases and attains higher levels of exposure upon oral dosing than comparable benzamidines and benzamidine isosteres. Compound I was efficacious in the canine AV model of thrombosis.

Journal of Medicinal Chemistry published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Buechert, Marina; Steenbock, Torben; Lukaschek, Christian; Wolff, Marie C.; Herrmann, Carmen; Heck, Juergen published the artcile< 2,2'-Bipyridine-Based Dendritic Structured Compounds for Second Harmonic Generation>, Quality Control of 112-63-0, the main research area is dendritic bipyridine second harmonic generation; amino compounds; bipyridine ligand; dendrimers; hyper-Rayleigh scattering; nonlinear optics.

Parallel alignment of dipolar electron-donor-π-bridge-electron-acceptor entities can strongly enhance their nonlinear optical properties. This favorable arrangement can be in principle achieved by linking these units covalently or through metal coordination. Four dipolar single-strand chromophores decorated with a 5-electron-donor-5′-electron-acceptor-modified 2,2′-bipyridine functionality were synthesized. For two of these chromophores triple-stranded dendritic structures were successfully formed. All of the compounds were characterized with respect to their linear and nonlinear optical properties. For the aldehyde derivatives an enhancement of the first hyperpolarizability of 4.5 rather than 3 was obtained when going from single to triple strands. Theor. calculations with d. functional theory suggest that interstrand transitions contribute to the optical properties of the dendritic structures.

Chemistry – A European Journal published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Quality Control of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Eldemerdash, Marwa M.; El-Sayed, Ashraf S. A.; Hussein, Hussein A.; Teleb, Samir S.; Shehata, Rania S. published the artcile< Molecular and metabolic traits of some Egyptian species of Cassia L. and Senna Mill (Fabaceae-Caesalpinioideae)>, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is Cassia Senna metabolism Egypt; Cassia; GC-MS profile; ITS sequence; RAPD analysis; Senna; Taxonomical features.

The genus Cassia and Senna have been classified under subfamily Caesalpinioideae of family Fabaceae (Leguminosae) of order Fabales. There is a scarce taxonomical studies of the genus Cassia and Senna inhabiting Egyptian environments, thus, the main objective of the current was to revise and authenticate the phylogenetic relationship between studied taxa of the species of the genera Cassia and Senna in Egypt using the recent tools of ITS barcoding, RAPD anal. and metabolic profiling, in comparing to the traditional taxonomical features. From the cluster anal. of the traditional 27 morphol. characters, the studied taxa were categorized into two major clades with an average taxonomic distance of 4.3. The clade I include Cassia fistula, C. renigera, C. javanica L subsp. nodosa and C. roughiia that belongs to series Obolospermae, and C. grandis that belongs to series Grandes. The clade (II) includes Senna surattensis and S. alata at taxonomic level 3.6. The taxonomical description of the studied taxa was confirmed from the mol. anal. of ITS sequences and RAPD anal. The ITS sequences of the tested plants species C. fistula L, C. grandis MD4, C. javanica subsp. nodosa MD7, C. roxburghii MD5, C. renigera MD5 were deposited at genbank with accession numbers MW367973, MZ960447, MW386305, MW326753 and MW32685, resp. While, the ITS sequences of the S. surrattensis and S. alata were deposited into genbank accession # MD14 MW367670 and MD20 MW412635, resp. Thus, from the mol. anal., two clades were clearly separated into Clade I of Cassia and Clade II of Senna. The cluster I represented by C. fistula, C. renigera, C. roxburghii, and C. javanica sub nodosa, and the cluster II represented by S. alata and S. surattensis. From the PCA of RAPD, a clearly discrimination between the two Taxa was observed revealing the characteristic grouping of Cassia and Senna. The species Senna alata and Senna surattensis were grouped together, but the species of C. renigera, C. javanica, C. roxburghii and C. grandis was grouped on a distinct group. The separation of Cassia and Senna species into two clusters verify the segregation of the genus Cassia L. senso lato into two distinct genera namely Senna P. and Cassia L. The morphol., mol. traits of the studied plants were authenticated from the metabolic profiling by GC-MS anal. Among the 23 identified metabolites, four compounds namely hexadecanoic acid, Me ester, 9-Octadecenoic acid (Z)-Et ester and Vitamin E were detected with fluctuated concentrations, among C. fistula, C. grandis, C. javanica subsp. nodosa and C. roxburghii. Conclusively, the traditional morphol. features, mol. barcoding using ITS sequences, RAPD anal. and metabolic traits by GC-MS anal., authenticates the taxonomical diversity of the genus Cassia and Senna.

BMC Plant Biology published new progress about Caesalpinioideae. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Recommanded Product: (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zheng, Ruixin; Shu, Chaozhu; Li, Jiabao; Hu, Anjun; Chen, Nian; Li, Minglu; Long, Jianping published the artcile< Oxygen vacancy engineering of vertically aligned NiO nanosheets for effective CO2 reduction and capture in Li-CO2 battery>, COA of Formula: C19H34O2, the main research area is oxygen vacancy vertically aligned nickel oxide nanosheet; carbon dioxide reduction capture lithium battery.

The Li-CO2 battery with the concept of turning waste into treasure has aroused great scientific research enthusiasm recently, but unfortunately it is a long shot for the large-scale applications of Li-CO2 battery due to its huge overpotential and poor cycling life at current stage. Herein, NiO nanosheets engineered by O vacancy growing vertically on C clothes (NiO-Vo@CC) was developed as viable catalyst for both CO2 reduction reaction (CO2RR) and CO2 evolution reaction (CO2ER) in Li- CO2 system. The O vacancy decorated by surplus electron will not only work as electron donor (Lewis base) surface to activated the electron-deficient C atom in CO2 but also narrow the band gap of NiO, therefore optimized CO2 conversion kinetic can be obtained by using defective NiO-Vo@CC electrode. The use of defect engineering to achieve performance improvement in aprotic Li-CO2 battery is still in its infancy at current stage and thus the authors’ research initially corroborates that modulation of the surface property via defect engineering can serve as valid strategy to design high performance electrodes for Li-CO2 battery.

Electrochimica Acta published new progress about Carbon fibers, fabrics Role: CAT (Catalyst Use), TEM (Technical or Engineered Material Use), USES (Uses). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, COA of Formula: C19H34O2.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Loenarz, Christoph; Mecinovic, Jasmin; Chowdhury, Rasheduzzaman; McNeill, Luke A.; Flashman, Emily; Schofield, Christopher J. published the artcile< Evidence for a stereoelectronic effect in human oxygen sensing>, Synthetic Route of 112-63-0, the main research area is stereoelectronic effect human oxygen sensing; proline conformation prolyl hydroxylase pVHL specificity.

How PHDs achieve specificity: trans-4-prolyl hydroxylation of the transcription factor HIF occurs with stereochem. retention. Substrate-analog studies show how the von Hippel Lindau tumor suppressor protein (pVHL) and the oxygen-sensing hydroxylases (PHDs) achieve specificity for hydroxyprolyl/prolyl residues for the C4-exo/endo prolyl conformations, resp.

Angewandte Chemie, International Edition published new progress about Homo sapiens. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Synthetic Route of 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhao, Chenglong; Jia, Xiao; Schols, Dominique; Balzarini, Jan; Meier, Chris published the artcile< γ-Non-Symmetrically Dimasked TriPPPro Prodrugs as Potential Antiviral Agents against HIV>, SDS of cas: 112-63-0, the main research area is HIV antiviral prodrug; antiviral agents; bioreversible protection; nucleoside analogue; nucleoside triphosphate prodrugs; nucleotides.

Nucleoside analog reverse transcriptase inhibitors (NRTI) and nucleoside analog monophosphate prodrugs are used in combination antiretroviral therapy (cART). The design of antivirally active nucleoside triphosphate prodrugs is a recent and an important advancement in the field of nucleoside analog drug development. Here, we report on TriPPPro-derivatives of nucleoside analog triphosphates (NTPs) that comprised two different acyloxybenzyl-masks at the γ-phosphate of the NTP aiming to achieve the metabolic bypass. Thus, γ-non-sym. dimasked TriPPPro-compounds (γ-(AB,ab)-d4TTPs) were synthesized and they proved to be active against HIV-1 and HIV-2 in cultures of infected wild-type human CD4+ T-lymphocyte (CEM/0) cells and more importantly also in thymidine kinase-deficient CD4+ T-cells (CEM/TK-). From hydrolysis studies both in phosphate buffer (PB, pH 7.3) and CEM cell extracts, there was surprisingly no differentiation in the cleavage of the two acyloxybenzyl prodrug-masks. However, if within one of the two acyloxybenzyl groups a short PEG-type methoxytriglycol group was introduced, the “”standard”” acyloxybenzyl-mask was cleaved with high preference.

ChemMedChem published new progress about Anti-HIV agents. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, SDS of cas: 112-63-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gao, Jia; Jiang, Donglin published the artcile< Covalent organic frameworks with spatially confined guest molecules in nanochannels and their impacts on crystalline structures>, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is covalent organic framework guest nanopore crystal structure.

The authors demonstrate the profound effects of spatially confined guest mols. in one-dimensional nanochannels on X-ray diffraction of covalent organic frameworks. The results give insights into the abnormal X-ray diffraction patterns and suggest a mol. dynamic strategy for resolving crystalline structures.

Chemical Communications (Cambridge, United Kingdom) published new progress about Covalent organic frameworks. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Safety of (9Z,12Z)-Methyl octadeca-9,12-dienoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics