Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 111-82-0, Name is Methyl laurate, SMILES is CCCCCCCCCCCC(OC)=O, belongs to esters-buliding-blocks compound. In a document, author is Rovito, Daniela, introduce the new discover, Product Details of 111-82-0.
Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia
The bioactive vitamin D-3, 1 alpha ,25(OH)(2)D-3, plays a central role in calcium homeostasis by controlling the activity of the vitamin D receptor (VDR) in various tissues. Hypercalcemia secondary to high circulating levels of vitamin D-3 leads to hypercalciuria, nephrocalcinosis and renal dysfunctions. Current therapeutic strategies aim at limiting calcium intake, absorption and resorption, or 1 alpha ,25(OH)(2)D-3 synthesis, but are poorly efficient. In this study, we identify WBP4 as a new VDR interactant, and demonstrate that it controls VDR subcellular localization. Moreover, we show that the vitamin D analogue ZK168281 enhances the interaction between VDR and WBP4 in the cytosol, and normalizes the expression of VDR target genes and serum calcium levels in 1 alpha ,25(OH)(2)D-3-intoxicated mice. As ZK168281 also blunts 1 alpha ,25(OH)(2)D-3-induced VDR signaling in fibroblasts of a patient with impaired vitamin D degradation, this VDR antagonist represents a promising therapeutic option for 1 alpha ,25(OH)(2)D-3-induced hypercalcemia. Current therapeutic strategies for vitamin D-induced hypercalcemia are poorly efficient. Here the authors identify a new interaction between the vitamin D receptor (VDR) and WBP4 controlling the subcellular localization of VDR and show that ZK168281, a VDR antagonist, enhances the interaction between VDR and WBP4 blunting VDR signalling and normalizing calcium levels in vitamin D-intoxicated mice.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 111-82-0 is helpful to your research. Product Details of 111-82-0.