Adding a certain compound to certain chemical reactions, such as: 110482-96-7, name is Ethyl 2,2-difluoropent-4-enoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 110482-96-7, Recommanded Product: Ethyl 2,2-difluoropent-4-enoate
PREPARATION 3 3,3-Difluoro-2-methyl-5-hexen-2-ol (Compound 4) To a solution of ethyl 2,2-difluoro-4-pentenoate (5.0 g, 30.5 mmol) in dry ether (50 ml) at -25 was added dropwise a solution of methyl magnesium bromide (3.0M; 30.5 ml). The mixture was stirred at -25 C. for half an hour and at 0 C. for 1 hour. The reaction mixture is poured into a saturated aqueous NH4 Cl solution (25 ml). The phases were separated and the aqueous phase was extracted with more ether (2*25 ml). The combined organic phases were dried with MgSO4 and concentrated. Flash chromatography (50 g silica gel, 5% ether in petroleum ether as eluant) to give the title compound as a colourless oil. NMR: delta=1.32 (t, 6H), 1.97 (bs, 1H), 2.74 (m, 2H), 5.20 (m, 2H), 5.92 (m, 1H) ppm.
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Reference:
Patent; Leo Pharmaceutical Products Ltd. A/S (L.o slashed.vens Kemiske Fabrik Produktionsaktieselskab); US5612325; (1997); A;,
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