Category: 1073353-89-5

Formula: C12H15BFNO4On March 7, 2014, Qiu, Di; Wang, Shuai; Tang, Shengbo; Meng, He; Jin, Liang; Mo, Fanyang; Zhang, Yan; Wang, Jianbo published an article in Journal of Organic Chemistry. The article was 《Synthesis of Trimethylstannyl Arylboronate Compounds by Sandmeyer-Type Transformations and Their Applications in Chemoselective Cross-Coupling Reactions》. The article mentions the following:

A synthetic method based on Sandmeyer-type reactions to access both tin- and boron-substituted arenes from nitroaniline derivatives is described. This transformation can be applied to the synthesis of a series of functionalized trimethylstannyl arylboronates. In addition, the chemoselective reaction of the Stille and Suzuki-Miyaura cross-coupling reactions is explored, and a series of m- and p-terphenyl derivatives have been synthesized by conducting consecutive one-pot Stille and Suzuki-Miyaura cross-coupling reactions. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 1073353-89-5Formula: C12H15BFNO4)

2-(2-Fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 1073353-89-5) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.Formula: C12H15BFNO4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2014,Chemistry – A European Journal included an article by Cairns, Andrew G.; Senn, Hans Martin; Murphy, Michael P.; Hartley, Richard C.. Product Details of 1073353-89-5. The article was titled 《Expanding the Palette of Phenanthridinium Cations》. The information in the text is summarized as follows:

5,6-Disubstituted phenanthridinium cations have a range of redox, fluorescence and biol. properties. Some properties rely on phenanthridiniums intercalating into DNA, but the use of these cations as exomarkers for the reactive oxygen species (ROS), superoxide, and as inhibitors of acetylcholine esterase (AChE) do not require intercalation. A versatile modular synthesis of 5,6-disubstituted phenanthridiniums that introduces diversity by Suzuki-Miyaura coupling, imine formation and microwave-assisted cyclization is presented. Computational modeling at the d. functional theory (DFT) level reveals that the novel displacement of the aryl halide by an acyclic N-alkylimine proceeds by an SNAr mechanism rather than electrocyclization. It is found that the displacement of halide is concerted and there is no stable Meisenheimer intermediate, provided the calculations consistently use a polarizable solvent model and a diffuse basis set. After reading the article, we found that the author used 2-(2-Fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 1073353-89-5Product Details of 1073353-89-5)

2-(2-Fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 1073353-89-5) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Product Details of 1073353-89-5 They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 1073353-89-5On November 15, 2012 ,《Antileishmanial bis-arylimidamides: DB766 analogs modified in the linker region and bis-arylimidamide structure-activity relationships》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Reid, Carolyn S.; Farahat, Abdelbasset A.; Zhu, Xiaohua; Pandharkar, Trupti; Boykin, David W.; Werbovetz, Karl A.. The article conveys some information:

Analogs of the lead antileishmanial bis-arylimidamide DB766 were prepared that possess unsym. substitutions on the diphenylfuran linker, and an addnl. compound was synthesized that contains isopropoxy groups meta to the central furan. These agents all displayed nanomolar in vitro potency against intracellular Leishmania with selectivity indexes >100 compared to J774 macrophages. While the unsym. analogs were toxic to mice when given i.p. at 30 mg/kg/day, the compound bearing the meta isopropoxy groups was well tolerated by mice and showed activity in a murine model of visceral leishmaniasis when administered i.p. at 30 mg/kg/day for five days.2-(2-Fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 1073353-89-5Application of 1073353-89-5) was used in this study.

2-(2-Fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 1073353-89-5) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Application of 1073353-89-5 They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Intramolecular aryl-aryl coupling via C-F bond activation tolerant towards C-I functionality》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Steiner, Ann-Kristin; Feofanov, Mikhail; Amsharov, Konstantin. Application of 1073353-89-5 The article mentions the following:

A transition-metal free activation of a particularly stable aromatic carbon-fluorine bond allowing intramol. aryl-aryl coupling which is orthogonal to carbon-iodine functionality was reported.2-(2-Fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 1073353-89-5Application of 1073353-89-5) was used in this study.

2-(2-Fluoro-4-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 1073353-89-5) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.Application of 1073353-89-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics