Application of 1068471-18-0, These common heterocyclic compound, 1068471-18-0, name is Methyl 3-(4-Ethynylphenyl)propanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Methyl 3-(4-ethynylphenyl) propanoate (1c) (243 mg, 1.29 mmol) was dissolved in7mL of N,N?- dimethylformamide (DMF). Copper (I) iodide (156 mg, 0.82 mmol),triethylamine (TEA 1.2mL, 8.23mmol), tetrakis (triphenylphosphine) palladium (0)(Pd(PPh3)4 475mg, 0.41mmol), trimethylsilylacetylene (TMSA 0.74 mL, 5.35 mmol),and iodobenzene (329mg, 1.61mmol) were added and the reaction mixture was stirred at80 C under Ar until all the starting material was consumed, as was monitored by TLC.The reaction mixture was filtered through a pad of celite and organic solvent (ethylacetate: n-hexane = 10:1) was added. The organic phase was washed two times withsaturated ammonium chloride, brine and then dried over magnesium sulfate. Thesolvent was evaporated under reduced pressure to yield the product (308 mg, 90%)
Statistics shows that Methyl 3-(4-Ethynylphenyl)propanoate is playing an increasingly important role. we look forward to future research findings about 1068471-18-0.
Reference:
Article; Ebara, Yasuhito; Hayashi, Tenko; Hori, Sakiko; Kaihatsu, Kunihiro; Kato, Nobuo; Ogata, Katsuya; Okazaki, Miku; Sawada, Shinjiro; Takagi, Kenji; Molecules; vol. 25; 4; (2020);,
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