Category: 106685-41-0

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 106685-41-0 as follows. Recommanded Product: 106685-41-0

Example 11; Preparation of 6-[3-(l-adamantyl)-4methoxy phenyl]-2 naphthoic acid (Adapalene) (I): The compound (V) (9.45 g, 22mmol) was dissolved in 1,4-Dioxane (95 ml) at reflux temperature and KOH (6.3 g, 11 mmol in 30 ml water) was added in a drop wise manner for 15 min. The reaction mixture was refluxed for 2-4 hrs and then cooled when the potassium salt of adapalene is precipitated, filtered and washed with methanol (25 ml). This salt of adapalene was acidified with 2 N HCl, solid separated, filtered and dried to obtain crude adapalene. The crude was recrystallized from THF-ethyl acetate. [Yield: 5.0 g, 81 %; Purity: HPLC > 99 %]

According to the analysis of related databases, 106685-41-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; USV LIMITED; WO2007/125542; (2007); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 106685-41-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 106685-41-0 as follows.

A round-bottom flask is loaded with adapalene methyl ester (7 g; 16.41 mmol), THF (42 ml), water (7 ml) and a 50% w/w sodium hydroxide aqueous solution (1.44 g; 18.05 mmol). The mixture is refluxed for 6 hours, then added with water (133 ml) and THF is distilled off to a residual content of approx. 5% w/w, heated to a temperature of about 80C until complete dissolution of the solid, then cooled to 15C. The crystallized product is filtered and dried under vacuum in a static dryer at a temperature of 50C, thereby obtaining adapalene sodium salt (6.7 g; 15.42 mmol) in 94% yield.

According to the analysis of related databases, 106685-41-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Dipharma S.p.A.; Lundbeck Pharmaceuticals Italy S.P.A.; EP1707555; (2006); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 106685-41-0, name is Methyl 6-(3-(adamantan-1-yl)-4-methoxyphenyl)-2-naphthoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 106685-41-0, HPLC of Formula: C29H30O3

Example 8; Preparation of Potassium salt of 6-[3-(l-adamantyl)-4-methoxy phenyl]-2 -naphthoic acid(VI):- To a solution of Methyl ester of 6-[3-(l-adamantyl)-4-methoxy phenyl] -2 naphthoic acid(25 g, 58 mmol) in 1,4-Dioxane ( 300ml) was stirred at refluxed temperature. Then potassium hydroxide (10 g, 175 mmol) in water (50 ml) was added slowly added into the reaction mixture. The reaction mixture was heated at 900C for 5 h. Then tetrahydrofuran(300 ml) was added slowly and again mixture was heated at 900C for 1 hr. The reaction mixture was cooled, solid separated, filtered and dried.[Yield: 24 g, 94 %]

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 6-(3-(adamantan-1-yl)-4-methoxyphenyl)-2-naphthoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; USV LIMITED; WO2007/125542; (2007); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics