Category: 106391-88-2

Rajagopal, Basker published the artcileCu(I)-Catalyzed Synthesis of Dihydropyrimidin-4-ones toward the Preparation of β- and β³-Amino Acid Analogues, COA of Formula: C10H19NO3, the publication is Journal of Organic Chemistry (2014), 79(3), 1254-1264, database is CAplus and MEDLINE.

A copper-(I)-catalyzed synthesis of substituted dihydropyrimidin-4-ones, e.g., I (X-rays single crystal structure shown), from propargyl amides via the formation of ketenimine intermediate has been successfully developed; the synthesis afforded good isolated yields (80-95%). The mild reaction conditions at room temperature allow the reaction to proceed to completion in a few hours without altering the stereochem. Further, by involving a variety of reactive nucleophiles, the obtained substituted dihydropyrimidin-4-ones were elegantly transformed into the corresponding β- and β³-amino acid analogs.

Journal of Organic Chemistry published new progress about 106391-88-2. 106391-88-2 belongs to esters-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Aldehyde, name is (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, and the molecular formula is C10H19NO3, COA of Formula: C10H19NO3.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Tappan, Erin published the artcileActivation of Protein Phosphatase 1 by a Small Molecule Designed to Bind to the Enzyme’s Regulatory Site, Computed Properties of 106391-88-2, the publication is Chemistry & Biology (Cambridge, MA, United States) (2008), 15(2), 167-174, database is CAplus and MEDLINE.

The activity of protein phosphatase 1 (PP1), a serine-threonine phosphatase that participates ubiquitously in cellular signaling, is controlled by a wide variety of regulatory proteins that interact with PP1 at an allosteric regulatory site that recognizes a “loose” consensus sequence (usually designated as RVXF) found in all such regulatory proteins. Peptides containing the regulatory consensus sequence have been found to recapitulate the binding and PP1 activity modulation of the regulatory proteins, suggesting that it might be possible to design small-mol. surrogates that activate PP1 rather than inhibiting it. This prospect constitutes a largely unexplored way of controlling signaling pathways that could be functionally complementary to the much more extensively explored stratagem of kinase inhibition. Based on these principles, we have designed a microcystin analog that activates PP1.

Chemistry & Biology (Cambridge, MA, United States) published new progress about 106391-88-2. 106391-88-2 belongs to esters-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Aldehyde, name is (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, and the molecular formula is C10H11NO4, Computed Properties of 106391-88-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Reddy Guduru, Shiva Krishna published the artcileSynthesis of Enantiomerically Pure 3-Substituted Piperazine-2-acetic Acid Esters as Intermediates for Library Production, Application In Synthesis of 106391-88-2, the publication is Journal of Organic Chemistry (2018), 83(19), 11777-11793, database is CAplus and MEDLINE.

Differentially protected 2,3-disubstituted piperazineacetates such as I and II (R = Me, PhCH₂, i-Bu; Ns = 2-O₂NC₆H₄SO₂; Boc = t-BuO₂C) were prepared for potential use in the synthesis of piperidine-containing combinatorial libraries. The piperazineacetates were prepared from L- or D-amino acids by acid reduction, oxidation and stereoselective Wittig olefination, Michael addition, amine protection with NsCl, cyclocondensation, and Boc deprotection and reprotection; the diastereomeric piperazines were separated Twenty monoprotected chiral 2,3-disubstituted piperazines, were prepared as single absolute stereoisomers; all but one were prepared in multigram quantities.

Journal of Organic Chemistry published new progress about 106391-88-2. 106391-88-2 belongs to esters-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Aldehyde, name is (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, and the molecular formula is C10H19NO3, Application In Synthesis of 106391-88-2.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Mali, Sachitanand M. published the artcileSynthesis of α, β-unsaturated γ-amino esters with unprecedented high (E)-stereoselectivity and their conformational analysis in peptides, Recommanded Product: (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, the publication is Organic & Biomolecular Chemistry (2011), 9(19), 6566-6574, database is CAplus and MEDLINE.

Mild, efficient and racemization-free synthesis of N-protected α, β-unsaturated γ-amino esters with unprecedented high E- stereoselectivity is described. This method is found to be compatible with Boc- (Boc = tert-butoxycarbonyl), Fmoc- (Fmoc = 9-fluorenylmethoxycarbonyl) and other side chain protecting groups. The crystal conformations of the vinylogous γ-amino esters in monomers and in homo- and mixed dipeptides are studied. Further, the vinylogous homo-dipeptide showed a β-sheet conformation, while mixed α- and α,β-unsaturated γ-hybrid dipeptide adapted an irregular structure in single crystals.

Organic & Biomolecular Chemistry published new progress about 106391-88-2. 106391-88-2 belongs to esters-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Aldehyde, name is (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, and the molecular formula is C10H19NO3, Recommanded Product: (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Winter-Holt, Jon J. published the artcileDiscovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models, Category: esters-buliding-blocks, the publication is Journal of Medicinal Chemistry (2022), 65(4), 3306-3331, database is CAplus and MEDLINE.

ATAD2 is an epigenetic bromodomain-containing target which is overexpressed in many cancers and has been suggested as a potential oncol. target. While several small mol. inhibitors have been described in the literature, their cellular activity has proved to be underwhelming. In this work, we describe the identification of a novel series of ATAD2 inhibitors by high throughput screening, confirmation of the bromodomain region as the site of action, and the optimization campaign undertaken to improve the potency, selectivity, and permeability of the initial hit. The result is compound 5 (AZ13824374)(I), a highly potent and selective ATAD2 inhibitor which shows cellular target engagement and antiproliferative activity in a range of breast cancer models.

Journal of Medicinal Chemistry published new progress about 106391-88-2. 106391-88-2 belongs to esters-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Amide,Aldehyde, name is (R)-tert-Butyl (3-methyl-1-oxobutan-2-yl)carbamate, and the molecular formula is C8H5F3O2S, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics