Category: 1061284-70-5

Synthesis and evaluation of α,α’-disubstituted phenylacetate derivatives for T-type calcium channel blockers was written by Lee, Hyung Kook;Lee, Yun Suk;Roh, Eun Joo;Rhim, Hyewhon;Lee, Jae Yeol;Shin, Kye Jung. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Name: Methyl 2-(4-bromophenyl)-3-methylbutanoate The following contents are mentioned in the article:

A number of α,α’-disubstituted phenylacetate derivatives were synthesized and evaluated as T-type calcium channel blockers. Among them, compound I (IC₅₀ = 8.17 ± 0.48 nM) showed the most potent T-type calcium current blocking activity and higher potency than Mibefradil (IC₅₀ = 1.34 ± 0.49 μM). The pharmacokinetic profile and subtype selectivity over L-type calcium channel were satisfied for further animal assay using disease model. This study involved multiple reactions and reactants, such as Methyl 2-(4-bromophenyl)-3-methylbutanoate (cas: 1061284-70-5Name: Methyl 2-(4-bromophenyl)-3-methylbutanoate).

Methyl 2-(4-bromophenyl)-3-methylbutanoate (cas: 1061284-70-5) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Name: Methyl 2-(4-bromophenyl)-3-methylbutanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Successful reduction of off-target hERG toxicity by structural modification of a T-type calcium channel blocker was written by Choi, Yeon Jae;Seo, Jae Hong;Shin, Kye Jung. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2014.Application of 1061284-70-5 The following contents are mentioned in the article:

To obtain an optimized T-type calcium channel blocker with reduced off-target hERG toxicity, we modified the structure of the original compound by introducing a zwitterion and reducing the basicity of the nitrogen. Among the structurally modified compounds we designed, compounds 5 and 6, which incorporate amides in place of the original compound’s amines, most appreciably alleviated hERG toxicity while maintaining T-type calcium channel blocking activity. Notably, the benzimidazole amide 5 selectively blocked T-type calcium channels without inhibiting hERG (hERG/T-type â‰?220) and L-type channels (L-type/T-type = 96), and exhibited an excellent pharmacokinetic profile in rats. This study involved multiple reactions and reactants, such as Methyl 2-(4-bromophenyl)-3-methylbutanoate (cas: 1061284-70-5Application of 1061284-70-5).

Methyl 2-(4-bromophenyl)-3-methylbutanoate (cas: 1061284-70-5) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application of 1061284-70-5

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics