Category: 10601-80-6

10601-80-6, The chemical industry reduces the impact on the environment during synthesis 10601-80-6, name is Ethyl 3,3-diethoxypropionate, I believe this compound will play a more active role in future production and life.

General procedure: 2-aminopyridine 1a (47 mg, 0.5 mmol), ethyl 3,3-diethoxypropanoate 2 (285 mg, 1.5 mmol) and p-TsOH (8.6 mg, 10 mol %) were stirred in 2 mL of toluene for 6 h at 80 C. After completion of the reaction (monitored by TLC), the water (10 mL) was added. The aqueous solution was extracted with ethyl acetate (3¡Á8 mL) and the combined extract was dried with anhydrous MgSO4. The solvent was removed and the crude product was separated by column chromatography (eluted with petroleum ether/ethyl acetate = 2:1) to give a pure sample of 3a (Yellow crystal, 100 mg, 82%).

The chemical industry reduces the impact on the environment during synthesis Ethyl 3,3-diethoxypropionate. I believe this compound will play a more active role in future production and life.

Reference:
Article; Liu, Wenjie; Wang, Shaohua; Zhan, Haiying; Li, Mingshan; Synlett; vol. 25; 10; (2014); p. 1478 – 1481;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

10601-80-6, Adding a certain compound to certain chemical reactions, such as: 10601-80-6, name is Ethyl 3,3-diethoxypropionate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10601-80-6.

Example 22-(6-Chloro-pyridin-2-yl)-pyrimidin-4-ol (Intermediate compound); Ethyl-3,3-diethoxypropionate (1 g, 5.26 ml_) was dissolved in tetrahydrofuran (2 ml_) and aqueous hydrochloric acid (1.5 M) was added. The reaction mixture was stirred at room temperature for 4 hours and extracted with ethyl acetate.The combined organic layers were washed with brine, dried over sodium sulphate, filtrated and evaporated. Ethanol (20 ml_) was added and cooled to 0C.Crude theta-chloro-pyridine^-carboxamidine (560 mg, 1.44 mmol) in water (5 ml_) was added and the reaction mixture was stirred for 15 minutes at 0C. Sodium hydroxide (841 mg, 21.03 mmol) was added followed by additional stirring at room temperature for 20 hours. The reaction mixture was concentrated under reduced pressure. Water was added and extracted with chloroform. The combined organic phases were washed with brine, dried over sodium sulphate filtated and evaporated to give 2-(6-chloro-pyridin-2-yl)-pyrimidin-4-ol (350 mg, 53%) as a brownish solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 3,3-diethoxypropionate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NeuroSearch A/S; WO2008/28935; (2008); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

10601-80-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10601-80-6, name is Ethyl 3,3-diethoxypropionate, This compound has unique chemical properties. The synthetic route is as follows.

Example 25 Preparation of 3,3-diethoxypropanoic acid Ref. . To a 250 mL round-bottomed flask with magnetic stirring that contained ethyl 3,3-diethoxypropanoate (20.0 g, 102.0 mmol, colourless oil, 97 %), a previously prepared solution of NaOH (5.23 g, 131.0 mmol) in H2O (30 mL) was added. The resulting mixture was stirred to reflux (100 C) during 1h. After allowing it to temper, the mixture was acidified using HCl 37 % and it was extracted with AcOEt, 8x 20 mL. The resulting organic phase was washed with 1x 20 mL NaCl sat., dried with Na2SO4, filtered and concentrated to dryness. The obtained oil was confirmed to correspond to the title compound (15.9 g, 98.0 mmol, 96 %).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Esteve Quimica, S.A.; EP2418192; (2012); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

10601-80-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10601-80-6, name is Ethyl 3,3-diethoxypropionate, This compound has unique chemical properties. The synthetic route is as follows.

Sodium hydride (2.00 g, 50.6 mmol, 60%) was added to a solution of ethyl formate (10.13 g, 168.7 mmol) in tetrahydrofuran while maintaining the internal temperature below 0 C. Then, ethyl 3,3-diethoxy propionate (5.00 g, 33.75 mmol) was added dropwise to the reaction mixture and stirred for 24 h at ambient temperature. After confirming that the reaction was complete by using TLC analysis, the reaction was quenched with 20 mL water and the tetrahydrofuran was removed under reduced pressure. The mixture was extracted with ethyl acetate and then brine. The organic phase was dried over Na2SO4 overnight and the solvent was removed in vacuo to give the title compound 14.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Zhao, Shizhen; Zhang, Xiangqian; Wei, Peng; Su, Xin; Zhao, Liyu; Wu, Mengya; Hao, Chenzhou; Liu, Chunchi; Zhao, Dongmei; Cheng, Maosheng; European Journal of Medicinal Chemistry; vol. 137; (2017); p. 96 – 107;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics