Category: 106-02-5

Synthetic Route of C15H28O2《Polymeric nanoparticles for the delivery of miRNA to treat Chronic Obstructive Pulmonary Disease (COPD)》 was published in 2019. The authors were Mohamed, Adel;Kunda, Nitesh K.;Ross, Kehinde;Hutcheon, Gillian A.;Saleem, Imran Y., and the article was included in《European Journal of Pharmaceutics and Biopharmaceutics》. The author mentioned the following in the article:

RNA interference (RNAi) based therapeutics are considered an endogenous mechanism for modulating gene expression. In addition, microRNAs (miRNAs) may be tractable targets for the treatment of Chronic Obstructive Pulmonary Disease (COPD). In this study miR146a was adsorbed onto poly (glycerol adipate-co-ω-pentadecalactone), PGA-co-PDL, nanoparticles (NPs) to reduce target gene IRAK1 expression. NPs were prepared using an oil-in-water single emulsion solvent evaporation method incorporating cationic lipid dioleoyltrimethylammoniumpropane (DOTAP). This resulted in NPs of 244.80 ± 4.40 nm at 15% DOTAP concentration, zeta potential (ZP) of +14.8 ± 0.26 mV and miR-146a (40μg/mL) maximum adsorption onto 15% DOTAP NPs was 36.25 ± 0.35μg per 10 mg NP following 24 h incubation. Using the MTT assay, it was observed that over 75% at 0.312 mg/mL of A549 cells remained viable after 18 h exposure to cationic NPs at a concentration of 1.25 mg/mL. Furthermore, the in vitro release profile of miR-146a from loaded NPs showed a continuous release up to 77% after 24 h. Internalization of miR-146a loaded cationic NPs was observed in A549 cell lines using fluorescence and confocal microscopy. The miR146a delivered as miR-146a-NPs had a dose dependent effect of highest NPs concentrations 0.321 and 0.625 mg/mL and reduced target gene IRAK1 expression to 40%. In addition, IL-8 promoter reporter output (GFP) was dampened by miR-146a-NPs. In conclusion, miR-146a was successfully adsorbed onto PGA-co-PDL-DOTAP NPs and the miR-146a retained biol. activity. Therefore, these results demonstrate the potential of PGA-co-PDL NPs as a delivery system for miR-146a to treat COPD. To complete the study, the researchers used Oxacyclohexadecan-2-one (cas: 106-02-5) .

Oxacyclohexadecan-2-one(cas:106-02-5) is a monomer used to make PGA-co-pentadecalactone polymers to be used in the development of directly compressed prolonged release tablets of slightly soluble drugs such as ketoprofen.Synthetic Route of C15H28O2It may be used for the synthesis of poly(pentadecanolide) (PPDL) by Novozyme 435 catalyzed ring-opening polymerization.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Formula: C15H28O2《Iridium-Catalyzed Reductive Allylation of Esters》 was published in 2019. The authors were Xie, Lan-Gui;Rogers, Jack;Anastasiou, Ioannis;Leitch, Jamie A.;Dixon, Darren J., and the article was included in《Organic Letters》. The author mentioned the following in the article:

The catalytic reductive transformation of carboxylic esters into α-branched ethers is described. The procedure pivots on the chemoselective iridium-catalyzed hydrosilylation of ester and lactone functionality to afford a silyl acetal intermediate. Upon treatment with a Lewis acid, these hemilabile intermediates dissociate to form reactive oxocarbenium ions, which can be intercepted by allyltributyltin nucleophiles, resulting in the formation of valuable α-branched alkyl-alkyl ether derivatives This reductive allylation procedure was found to be amenable to a range of carboxylic ester starting materials, and good chemoselectivity for Et over tert-Bu esters was demonstrated. Furthermore, downstream synthetic manipulation of α-amino acid-derived products led to the efficient formation of pyrrolidine, piperidine, and azepane frameworks. And Oxacyclohexadecan-2-one (cas: 106-02-5) was used in the research process.

Oxacyclohexadecan-2-one(cas:106-02-5) is a natural product found in Lonicera japonica and Angelica archangelica.Formula: C15H28O2 It is a macrocyclic lactone that can be used as a flavoring agent and fragrance ingredient due to its musk flavor/odor.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Quality Control of Oxacyclohexadecan-2-one《Highly selective macrocyclic ring-closing metathesis of terminal olefins in non-chlorinated solvents at low dilution》 was published in 2019. The authors were Dumas, Adrien;Colombel-Rouen, Sophie;Curbet, Idriss;Forcher, Gwenael;Tripoteau, Fabien;Caijo, Frederic;Queval, Pierre;Rouen, Mathieu;Basle, Olivier;Mauduit, Marc, and the article was included in《Catalysis Science & Technology》. The author mentioned the following in the article:

Bis(cycloalkylarylimidazolylidene)ruthenium indenylidene complexes were prepared as catalysts for ring-closing metatheses of dienes to yield macrocycles, particularly macrocyclic lactone odorants, without isomerization and without using chlorinated solvents. Ring-closing metatheses were performed in EtOAc at 0.01 M substrate concentrations without requiring 1,4-benzoquinone to suppress isomerization. Macrocyclic odorant mols. were prepared in >99% purities by this method. And Oxacyclohexadecan-2-one (cas: 106-02-5) was used in the research process.

Oxacyclohexadecan-2-one(cas:106-02-5) is a monomer used to make PGA-co-pentadecalactone polymers to be used in the development of directly compressed prolonged release tablets of slightly soluble drugs such as ketoprofen.Quality Control of Oxacyclohexadecan-2-oneIt may be used for the synthesis of poly(pentadecanolide) (PPDL) by Novozyme 435 catalyzed ring-opening polymerization.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Wen-Qing;Yu, Zhong-Na;Ho, Harvey;Wang, Jun;Wang, Yu-Tao;Fan, Rong-Bo;Han, Rong-Wei published 《Analysis of veterinary drug residues in pasteurized milk samples in Chinese milk bars》. The research results were published in《Journal of Food Protection》 in 2020.COA of Formula: C15H28O2 The article conveys some information:

The objective of this study was to investigate the safety of PM from a total of 182 PM samples collected from milk bars from 10 provincial capital cities and to analyze the residues of seven classes of 61 veterinary drugs. First, the chem. components were screened with test kits, and then the pos. samples were further confirmed by ultraperformance liquid chromatog.-tandem mass spectrometry. The results showed that 15 (8.24%) samples were screened pos. for veterinary drugs, and six drugs in 11 (6.04%) samples were confirmed. The veterinary drugs detected were penicillin G (2.20%), tetracycline (1.10%), tylosin (1.10%), amoxicillin (0.55%), oxytetracycline (0.55%), and gentamicin (0.55%), with maximum residue levels of 3.4, 11.9, 28.2, 3.0, 26.9, and 63.5μg kg-1, resp. Veterinary drug residues were detected as pos. in 7 of 10 cities, with the highest detection rate as 14.29% in Urumqi. No pos. samples were found in the cities of Nanjing, Tianjin, and Nanning. All detected drug levels were far below the maximum residue levels regulated by China, the European Union, and the Codex Alimentarius Commission. This suggests that the overall veterinary drug residues in PM in milk bars reached the safety code of the country. However, potential risks still exist, and continuous attention should be paid to guarantee the safety of this milk product in the future.Oxacyclohexadecan-2-one (cas: 106-02-5) were involved in the experimental procedure.

Oxacyclohexadecan-2-one(cas:106-02-5) is a natural product found in Lonicera japonica and Angelica archangelica.COA of Formula: C15H28O2 It is a macrocyclic lactone that can be used as a flavoring agent and fragrance ingredient due to its musk flavor/odor.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of C15H28O2In 2022, Lee, Woorim;Shin, Jaedon;Lee, Minju;Choi, Yegyun;Son, Heejong;Lee, Yunho published 《Elimination efficiency of synthetic musks during the treatment of drinking water with ozonation and UV-based advanced oxidation processes》. 《Science of the Total Environment》published the findings. The article contains the following contents:

This study investigated the reaction kinetics and elimination efficiency of eleven synthetic musks during ozonation and UV254nm-based, advanced oxidation processes. The synthetic musks containing olefin moieties with electron-donating alkyl substituents such as octahydro tetra-Me naphthalenyl ethanone (OTNE) and ambrettolide (AMBT) showed high reactivity toward ozone (k ≥ 3.7 x 105 M-1 s-1) and free available chlorine (FAC) (k = 9.2 – 88 M-1 s-1), while all other synthetic musks were less ozone reactive (k = 0.3 – 560 M-1 s-1) and FAC-refractory. All synthetic musks showed high •OH reactivity (k > 5 x 109 M-1 s-1), except musk ketone (MK) (k = 2.3 x 109 M-1 s-1). In concordance with the kinetic information, OTNE and AMBT were efficiently eliminated (>97%) in simulated ozone treatments of drinking water at a specific ozone dose of 0.5 gO3/gDOC. The elimination levels of the other synthetic musks were below 50% at 0.5 gO3/gDOC. The fluence-based UV photolysis rate constant of the synthetic musks was determined to be (0.2 – 2.7) x 10-3 cm2/mJ. The elimination levels of synthetic musks during UV alone treatment ranged from 7 to 81% at a UV fluence of 500 mJ/cm2. The addition of 10 mg/L H2O2 (UV/H2O2) significantly enhanced the elimination of most synthetic musks (achieving >90% elimination at 500 mJ/cm2), indicating that the •OH reaction was mainly responsible for their elimination. The addition of 10 mg/L FAC (UV/FAC) also significantly enhanced the elimination of olefinic and aromatic synthetic musks (>90%), for which the reaction with ClO• was mainly responsible. For MK and two alkyl synthetic musks, their elimination during UV/FAC treatment was still limited (28 – 64%) and was mainly achieved by UV photolysis or reaction with •OH. In summary, this study substantiates the chem. kinetics approach as a helpful tool for predicting or interpreting the elimination of micropollutants during oxidative water treatment. And Oxacyclohexadecan-2-one (cas: 106-02-5) was used in the research process.

Oxacyclohexadecan-2-one(cas:106-02-5) is a natural product found in Lonicera japonica and Angelica archangelica.Electric Literature of C15H28O2 It is a macrocyclic lactone that can be used as a flavoring agent and fragrance ingredient due to its musk flavor/odor.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Phatake, Ravindra S.;Nechmad, Noy B.;Reany, Ofer;Lemcoff, N. Gabriel published 《Highly Substrate-Selective Macrocyclic Ring Closing Metathesis》. The research results were published in《Advanced Synthesis & Catalysis》 in 2022.Product Details of 106-02-5 The article conveys some information:

A selective ring-closing metathesis (RCM) reaction for the formation of large macrocycles, e.g., I by using latent sulfur chelated ruthenium iodide benzylidenes, readily activated by thermal and photochem. (UV-A and visible light) stimuli, is reported. For dienes, e.g., (E)-Henicosa-1,19-dien-10-one having one terminal alkene and one internal double bond, the specific affinity of diiodo ruthenium alkylidenes for the unhindered terminus, combined with their reluctance to react with internal olefins, favors RCM over oligomerization, providing high macrocyclic yields even at relatively high concentrations Alternatively, for substrates containing two internal double bonds, a sacrificial methylene donor can be used to obtain the desired products. With this methodol., lactones, lactams, and macrocyclic ketones ranging from 13- to 22-membered rings could be synthesized in moderate to high yields. In addition, synthetic applications for a one-pot cyclization/reduction sequence to produce Exaltolide, a natural macrolide (com. musk), Dihydrocivetone, and other saturated macrocycles have been explored. An important advantage for diiodo ruthenium benzylidene catalysts over their less selective dichloro counterparts provides a more profound understanding of the mechanisms that provide the enhanced cyclization outcome. And Oxacyclohexadecan-2-one (cas: 106-02-5) was used in the research process.

Oxacyclohexadecan-2-one(cas:106-02-5) is a natural product found in Lonicera japonica and Angelica archangelica.Product Details of 106-02-5 It is a macrocyclic lactone that can be used as a flavoring agent and fragrance ingredient due to its musk flavor/odor.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Recommanded Product: 106-02-5《Role prediction of Gram-negative species in the resistome of raw cow’s milk》 was published in 2021. The authors were Nikoloudaki, Olga;Lemos, Wilson J. F. Junior;Campanaro, Stefano;Di Cagno, Raffaella;Gobbetti, Marco, and the article was included in《International Journal of Food Microbiology》. The author mentioned the following in the article:

Extended use of antibiotics in dairy farming for therapeutic and prophylactic reasons, but also the higher prevalence of antibiotic resistant bacteria (ARB) in the farm environment raised the concern of consuming raw cow’s milk and its derived products. The aim of this study was to predict by shotgun metagenomic analyses the presence of antibiotic resistance genes (ARGs) mainly correlated with Gram-neg. bacteria in antibiotic residue free raw cow’s milk derived exclusively from healthy animal from South Tyrol (Northern Italy), chosen as a model system. Assessment of shotgun metagenomic data of reconstructed scaffolds, revealed the existence of Pseudomonas spp. as the most abundant Gram-neg. species in the raw cow’s milk samples bearing ARGs. Besides, ARGs also linked to lactic acid bacteria such as Lactococcus sp. and Lactobacillus sp. ARGs correlated to microbiome found in milk samples conferred resistance towards aminoglycoside-streptothricin, beta-lactamase, macrolide, tetracycline, carbapenem, cephalosporin, penam, peptide, penem, fluoroquinolone, chloramphenicol and elfamycin antibiotics. Further bioinformatic processing included de-novo reassembly of all metagenomic sequences from all milk samples in one, to reconstruct metagenome assembled genomes (MAGs), which were further used to investigate mobile genetic elements (MGE). Analyses of the reconstructed MAGs showed that, MAG 9 (Pseudomonas sp1.) contained the oriT gene (origin of transfer gene) needed for transferring virulent factors. Although the presence of Pseudomonas is common in raw cow’s milk, pasteurization treatment reduces their survivability. Nevertheless, attention should be paid on Pseudomonas spp. due to their intrinsic resistance to antibiotics and their capability of transferring virulent factors to other bacteria.Oxacyclohexadecan-2-one (cas: 106-02-5) were involved in the experimental procedure.

Oxacyclohexadecan-2-one(cas:106-02-5) is a monomer used to make PGA-co-pentadecalactone polymers to be used in the development of directly compressed prolonged release tablets of slightly soluble drugs such as ketoprofen.Recommanded Product: 106-02-5It may be used for the synthesis of poly(pentadecanolide) (PPDL) by Novozyme 435 catalyzed ring-opening polymerization.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Ziyue;Zhao, Yanxia;Prior, Timothy J.;Elsegood, Mark R. J.;Wang, Kuiyuan;Xing, Tian;Redshaw, Carl published 《Mono-oxo molybdenum(VI) and tungsten(VI) complexes bearing chelating aryloxides: synthesis, structure and ring opening polymerization of cyclic esters》. The research results were published in《Dalton Transactions》 in 2019.Related Products of 106-02-5 The article conveys some information:

The mono-oxo aryloxide complexes [M(O)(L¹)₂] (M = Mo (1·hexane), W(2·2MeCN)) were prepared from [Mo(O)(Cl)₄] or [W(O)(Ot-Bu)₄] and two equivalent of the di-phenol 2,2′-ethylidenebis(4,6-di-tert-butylphenol) L¹H₂, resp. Use of in situ generated [Mo(O)(Ot-Bu)₄] with two equivalent of L¹H₂ also gave 1·2MeCN. In the presence of adventitious oxygen, attempts to generate in situ [Mo(O)(Ot-Bu)₄] and reaction with one equivalent of L¹H₂ afforded the bi-metallic complex [Mo(O)(L¹)(μ-O)Li(THF)(MeCN)]₂·2MeCN (3·2MeCN). Use of the tetra-phenol α,α,α’,α’-tetrakis(3,5-di-tert-butyl-2-hydroxyphenyl)-p-xyleneH₄ (L²H₄) with [Mo(O)(Oi-Pr)₄] gave {[Mo(O)]L²}₂ (4), while the analogous W complex {[W(O)]L²}₂ (5) was isolated from the reaction of L²H₄ with [W(O)(Ot-Bu)₄]. Similar reaction of p-tert-butylcalix[4]areneH₄ (L³H₄) with [Mo(O)(Oi-Pr)₄] afforded [Mo(O)L³(NCMe)]·3MeCN (6). Modifications of known routes were employed to access complexes [W(Cl)₂L³]·3.5MeCN (7·3.5MeCN) and [W(O)L³(NCMe)] (8), while use of [WO(Ot-Bu)₄] with L³H₄ unexpectedly afforded [W(Ot-Bu)₂L³]·MeCN (9·MeCN). The mol. crystal structures for 1–9 are reported, and the ability of these complexes to act as catalysts for the ring opening polymerization (ROP) of ε-caprolactone (ε-CL), δ-valerolactone (δ-VL) and ω-pentadecalactone (ω-PDL) was studied. The Mo complexes 1 and 4 were the best performers for ε-Cl and δ-VL, but all complexes exhibited poor control and were also inactive toward the ROP of PDL.Oxacyclohexadecan-2-one (cas: 106-02-5) were involved in the experimental procedure.

Oxacyclohexadecan-2-one(cas:106-02-5) is a monomer used to make PGA-co-pentadecalactone polymers to be used in the development of directly compressed prolonged release tablets of slightly soluble drugs such as ketoprofen.Related Products of 106-02-5It may be used for the synthesis of poly(pentadecanolide) (PPDL) by Novozyme 435 catalyzed ring-opening polymerization.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lee, Isabelle;Na, Mihwa;O’Brien, Devin;Parakhia, Rahul;Alepee, Nathalie;Westerink, Walter;Eurlings, Irene;Api, Anne Marie published 《Assessment of the skin sensitization potential of fragrance ingredients using the U-SENS assay》 in 2022. The article was appeared in 《Toxicology In Vitro》. They have made some progress in their research.COA of Formula: C15H28O2 The article mentions the following:

The U-SENS assay was developed to address the third key event of the skin sensitization adverse outcome pathway (AOP) and is described in OECD test guideline 442E, Annex II. A dataset of 68 fragrance ingredients comprised of 7 non-sensitizers and 61 sensitizers was tested in the U-SENS assay. The potential for fragrance ingredients to activate dendritic cells, measured by U-SENS, was compared to the sensitization potential determined by weight of evidence (WoE) from historical data. Of the non-sensitizers, 4 induced CD86 cell surface marker ≥1.5-fold while 3 did not. Of the sensitizers, 50 were predicted to be pos. in U-SENS, while the remaining 11 were neg. Pos. and neg. predictive values (PPV and NPV) of U-SENS were 93% and 21%, resp. No specific chem. property evaluated could account for misclassified ingredients. Assessment of parent and metabolite protein binding alerts in silico suggests that parent chem. metabolism may play a role in CD86 activation in U-SENS. Combining the U-SENS assay in a “2 out of 3” defined approach with the direct peptide reactivity assay (DPRA) and KeratinoSens predicted sensitization hazard with PPV and NPV of 97% and 24%, resp. Combining complementary in silico and in vitro methods to the U-SENS assay should be integrated to define the hazard classification of fragrance ingredients, since a single NAM cannot replace animal-based methods. The experimental procedure involved many compounds, such as Oxacyclohexadecan-2-one (cas: 106-02-5) .

Oxacyclohexadecan-2-one(cas:106-02-5) is a monomer used to make PGA-co-pentadecalactone polymers to be used in the development of directly compressed prolonged release tablets of slightly soluble drugs such as ketoprofen.COA of Formula: C15H28O2It may be used for the synthesis of poly(pentadecanolide) (PPDL) by Novozyme 435 catalyzed ring-opening polymerization.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Product Details of 106-02-5In 2019, Gong, Yi-hong;Shu, Man;Xie, Jian-hua;Zhang, Chao;Cao, Zhong;Jiang, Zhao-zhong;Liu, Jie published 《Enzymatic synthesis of PEG-poly(amine-co-thioether esters) as highly efficient pH and ROS dual-responsive nanocarriers for anticancer drug delivery》. 《Journal of Materials Chemistry B: Materials for Biology and Medicine》published the findings. The article contains the following contents:

Novel multifunctional drug nanocarriers have been successfully fabricated from a new type of enzymically synthesized, biodegradable block copolymer, PEG-poly(ω-pentadecalactone-co-N-methyldiethyleneamine-co-3,3′-thiodipropionate) (PEG-PPMT), which was responsive to tumor-relevant acidic pH (5.0-6.5) and intracellular reactive oxygen species (ROS) of tumor cells. The PEG-PPMT copolymers could self-assemble to form nano-scaled particles in aqueous solutions, which are stable in physiol. solutions, but swell substantially upon reducing the pH from 7.4 to 5.0 and/or in the presence of ROS on account of the protonation of the tertiary amino groups and oxidation of the thioether groups, causing a hydrophobic to hydrophilic transition in the nanoparticle cores. Consistently, docetaxel (DTX) encapsulated in PEG-PPMT nanoparticles can be triggered in a synergistic manner by acidic pH and a high-ROS environment in tumor cells to release the hydrophobic drug at accelerated rates for efficient tumor growth inhibition. In particular, DTX encapsulated in PEG-PPMT-11% PDL and PEG-PPMT-28% PDL nanoparticles exhibit extraordinarily enhanced potency (95% and 93% tumor-inhibiting efficiency, resp.) in inhibiting the growth of ROS-rich CT-26 tumors xenografted in mice. Importantly, biosafety analyses show minimal toxicity of DTX-loaded PEG-PPMT nanoparticles toward normal organs including liver and kidneys during the in vivo antitumor treatments. These results demonstrate that the PEG-PPMT nanoparticles are promising pH and ROS dual-responsive multifunctional nanocarriers for tumor site specific, controlled release of anticancer drugs to treat ROS-rich tumors.Oxacyclohexadecan-2-one (cas: 106-02-5) were involved in the experimental procedure.

Oxacyclohexadecan-2-one(cas:106-02-5) is a natural product found in Lonicera japonica and Angelica archangelica.Product Details of 106-02-5 It is a macrocyclic lactone that can be used as a flavoring agent and fragrance ingredient due to its musk flavor/odor.

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics