Category: 10472-24-9

On July 31, 2020, Mekki, Amel; Benmaati, Aouicha; Mokhtar, Adel; Hachemaoui, Mohammed; Zaoui, Farouk; Habib Zahmani, Hadjira; Sassi, Mohamed; Hacini, Salih; Boukoussa, Bouhadjar published an article.Category: esters-buliding-blocks The title of the article was Michael Addition of 1,3-Dicarbonyl Derivatives in the Presence of Zeolite Y as an Heterogeneous Catalyst. And the article contained the following:

This paper focuses on the preparation and modification of zeolite Y by different methods. The obtained samples were characterized by X-ray diffraction, X-ray fluorescence, nitrogen adsorption-desorption and zeta potential measurements. The obtained catalysts were tested in the Michael addition reaction. Several parameters affecting the Michael reaction such as the catalyst nature, catalyst mass, solvent and to generalize the reaction several acceptors were tested. The results showed that zeolite Y had a larger sp. surface area, but their modified counterparts showed weak surfaces due to the partial destruction of zeolite framework after the different treatments. The catalytic application of zeolite Y and its modified counterparts had shown interesting results via the addition of Michael with yields between 70 and 100%. Reuse of zeolite Y in several cycles showed that this catalyst was stable during six consecutive reuse tests. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Category: esters-buliding-blocks

The Article related to zeolite y catalyst preparation surface area, dicarbonyl unsaturated compound zeolite y michael addition microwave irradiation, Alicyclic Compounds: General and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 14, 2019, Wang, Shuai; Zhao, Lijie; Shi, Xiao-Jing; Ding, Lina; Yang, Linlin; Wang, Zhi-Zheng; Shen, Dandan; Tang, Kai; Li, Xiao-Jing; Mamun, MAA; Li, Huiju; Yu, Bin; Zheng, Yi-Chao; Wang, Shaomeng; Liu, Hong-Min published an article.Related Products of 10472-24-9 The title of the article was Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5-a]pyrimidine-Based Inhibitors Targeting the DCN1-UBC12 Protein-Protein Interaction. And the article contained the following:

The cullin-RING ubiquitin ligases (CRLs) are responsible for about 20% of cellular protein degradation and regulate diverse cellular processes, and the dysfunction of CRLs is implicated in human diseases. Targeting the CRLs has become an emerging strategy for the treatment of human diseases. Herein, we describe the discovery of a hit compound from our inhouse library and further structure-based optimizations, which have enabled the identification of new triazolo[1,5-a]pyrimidine-based inhibitors targeting the DCN1-UBC12 interaction. Compound WS-383 blocks the DCN1-UBC12 interaction (IC50 = 11 nM) reversibly and shows selectivity over selected kinases. WS-383 exhibits cellular target engagement to DCN1 in MGC-803 cells. WS-383 inhibits Cul3/1 neddylation selectively over other cullins and also induces accumulation of p21, p27, and NRF2. Collectively, targeting the DCN1-UBC12 interaction would be a viable strategy for selective neddylation inhibition of Cul3/1 and may be of therapeutic potential for disease treatment in which Cul3/1 is dysregulated. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Related Products of 10472-24-9

The Article related to triazolo pyrimidine derivative preparation dcn1 ubc12 protein interaction cancer, Pharmacology: Structure-Activity and other aspects.Related Products of 10472-24-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Zhi-Min; Liu, Jianbo; Guo, Jing-Yao; Loch, Maximillan; DeLuca, Ryan J.; Sigman, Matthew S. published an article in 2019, the title of the article was Palladium-catalyzed enantioselective alkenylation of alkenylbenzene derivatives.Product Details of 10472-24-9 And the article contains the following content:

A regioselective and enantioselective palladium-catalyzed relay Heck alkenylation of alkenylbenzene derivatives to construct remote stereocenters was disclosed. Various β-substituted styrenes were readily obtained in moderate yields with good to excellent levels of enantioselectivity. This strategy provided rapid access to enantioenriched δ, ε, ζ and η-alkenyl aryl compounds from simple starting materials. Mechanistic studies suggested that termination of the relay reaction was controlled by affinity of the arene for the Pd complex during migration. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Product Details of 10472-24-9

The Article related to alkenylarene alkenyl triflate palladium catalyst regioselective enantioselective heck reaction, Alicyclic Compounds: Cyclohexanes and other aspects.Product Details of 10472-24-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 22, 2021, Wang, Yongtao; Lu, Rui; Yao, Jia; Li, Haoran published an article.SDS of cas: 10472-24-9 The title of the article was 1,5,7-Triazabicyclo[4.4.0]dec-5-ene Enhances Activity of Peroxide Intermediates in Phosphine-Free α-Hydroxylation of Ketones. And the article contained the following:

The critical role of double hydrogen bonds was addressed for the aerobic α-hydroxylation of ketones catalyzed by 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD), in the absence of either a metal catalyst or phosphine reductant. Exptl. and theor. investigations were performed to study the mechanism. In addition to initiating the reaction by proton abstraction, a more important role of TBD was revealed, i.e., to enhance the oxidizing ability of peroxide intermediates, allowing DMSO to be used rather than commonly used phosphine reductants. Further characterizations with nuclear Overhauser effect spectroscopy (NOESY) confirmed the presence of double hydrogen bonds between TBD and the ketone, and kinetic studies suggested the attack of dioxygen on the TBD-enol adduct to be the rate-determining step. This work should encourage the application of TBD as a catalyst for oxidations The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).SDS of cas: 10472-24-9

The Article related to aerobic hydroxylation ketone triazabicyclodecene catalyst green chem mol modeling, aerobic hydroxylation, double hydrogen bonds, guanidine, peroxide, reaction mechanism, Alicyclic Compounds: Cyclohexanes and other aspects.SDS of cas: 10472-24-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 1, 2019, Spender, Lindsay C.; John Ferguson, G.; Hughes, Gareth D.; Davies, Barry R.; Goldberg, Frederick W.; Herrera, Blanca; Taylor, Richard G.; Strathearn, Lauren S.; Sansom, Owen J.; Barry, Simon T.; Inman, Gareth J. published an article.COA of Formula: C7H10O3 The title of the article was Preclinical evaluation of AZ12601011 and AZ12799734, inhibitors of transforming growth factor beta superfamily type 1 receptors. And the article contained the following:

Here, we characterize the biol. effects of two transforming growth factor beta receptor 1 (TGFBR1) kinase inhibitors designed to target TGFbeta signaling. AZ12601011 [2-(2-pyridinyl)-4-(1H-pyrrolo[3,2-c]pyridin-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine]; structure previously undisclosed] and AZ12799734 [4-({4-[(2,6-dimethyl-3-pyridinyl) oxy]-2-pyridinyl}amino)benzenesulfonamide] (IC50 = 18 and 47 nM, resp.) were more effective inhibitors of TGF beta-induced reporter activity than SB-431542 [4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide] (IC50 = 84 nM) and LY2157299 [4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[ 1,2-b]pyrazol-3-yl]quinoline-6-carboxamide monohydrate]] (galunisertib) (IC50 = 380 nM). AZ12799734, however, is a pan TGF/BMP inhibitor, inhibiting receptor-mediated phosphorylation of SMAD1 by activin A receptor type 1L, bone morphogenetic protein receptor type 1A, and bone morphogenetic protein receptor type 1B and phosphorylation of SMAD2 by ALK4, TGFBR1, and ALK7. AZ12601011 was highly effective at inhibiting basal and TGF beta-induced migration of HaCaT keratinocytes and, furthermore, inhibited tumor growth and metastasis to the lungs in a 4T1 syngeneic orthotopic mammary tumor model. These inhibitors provide new reagents for investigating in vitro and in vivo pathogenic processes and the contribution of TGF beta- and BMP-regulated signaling pathways to disease states. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).COA of Formula: C7H10O3

The Article related to fibroblast tgf beta smad2 smad1, Placeholder for records without volume info and other aspects.COA of Formula: C7H10O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Leguil, Malika; Lahrech, Mokhtar Boualem; Souli, Lahcene; Benalia, Mokhtar published an article in 2022, the title of the article was One-pot three-component synthesis of chromeno[4,3-C] pyrazol carbothioamide and chromeno[4,3,2-CD]indazol carbothioamide derivatives using piperidines as an efficient catalyst.SDS of cas: 10472-24-9 And the article contains the following content:

A green, efficient, and rapid procedure for the one-pot synthesis of novel chromeno[4,3-c]pyrazole carbotioamide and chromeno[4,3,2-cd]indazole-1- derivatives from salicylaldehyde, 1,3-dicarbonyl compounds and 2-aminobenzimidazole, under reflux conditions catalyzed by piperidine in acetic acid. The reactions are realized in short time (12h) giving an excellent yield (55-98%). The novel synthesized chromeno[4,3-c]pyrazole carbotioamide and chromeno[4,3,2-cd]indazole-1-derivatives were characterized by FT-IR, 1H NMR and 13C NMR spectroscopic techniques. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).SDS of cas: 10472-24-9

The Article related to chromeno pyrazol carbothioamide derivative one pot synthesis, Placeholder for records without volume info and other aspects.SDS of cas: 10472-24-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 31, 2019, Maximuck, William J.; Gladysz, John A. published an article.Reference of Methyl 2-cyclopentanonecarboxylate The title of the article was Lipophilic chiral cobalt (III) complexes of hexaamine ligands: Efficacies as enantioselective hydrogen bond donor catalysts. And the article contained the following:

Four known chiral enantiopure octahedral Co(III) trichloride salts with aliphatic hexaamine ligands are converted to new CH2Cl2 soluble tris(tetraarylborate) or 3BArf- salts (BArf = B(3,5-C6H3(CF3)2)4) in biphasic reactions. These include sepulchrate and sarcophagine complexes in which the hexaamine ligands are bicyclic (Z(CH2NHCH2CH2NHCH2)3Z, Z = N, CX), as well as a truncated sarcophagine in which a missing C vertex renders the ligand acyclic and tripodal, with 3 terminal NH2 groups that define a trigonal C3 sym. face (CH3C(CH2NHCH2CH2NH2)3). In the presence of tertiary amine bases, these are effective catalysts for 2 Michael type C-C bond forming reactions and a related C-N bond forming reaction. Only the last complex affords significant enantioselectivities (30-57% ee). Rationales, and directions for future catalyst optimization, are proposed. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Reference of Methyl 2-cyclopentanonecarboxylate

The Article related to cobalt hexaamine lipophilic chiral complex enantioselective hydrogen bond catalyst, Placeholder for records without volume info and other aspects.Reference of Methyl 2-cyclopentanonecarboxylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ullah, Mohammad Shahid; Chhanda, Sadia Afrin; Itsuno, Shinichi published an article in 2020, the title of the article was ADMET polymerization of dimeric cinchona squaramides for the preparation of a highly enantioselective polymeric organocatalyst.SDS of cas: 10472-24-9 And the article contains the following content:

Under the acyclic diene metathesis (ADMET) reaction condition, the C3-vinyl groups of cinchona alkaloids readily react with each other to form a C-C bond. A novel type of cinchona alkaloid polymers was synthesized from dimeric cinchona squaramides using the Hoveyda-Grubbs′ second-generation catalysts (HG2) by means of ADMET reaction. The chiral polymers, containing cinchona squaramide moieties in their main chains, were subsequently employed as catalysts for the enantioselective Michael reaction to give the corresponding chiral adducts in high yields with excellent enantioselectivity and diastereoselectivity. Both enantiomers from the asym. Michael reaction were distinctively prepared while using the polymeric catalysts, possessing pseudoenantiomeric structures. The catalysts were readily recovered from the reaction mixture and recycled several times due to the insolubility of the cinchona-based squaramide polymers. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).SDS of cas: 10472-24-9

The Article related to acyclic diene metathesis polymerization dimeric cinchona squaramide polymeric organocatalyst, Placeholder for records without volume info and other aspects.SDS of cas: 10472-24-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhu, Liru; Guo, Yonghong; Zu, Bing; Ke, Jie; He, Chuan published an article in 2022, the title of the article was Electrochemical α-thiolation and azidation of 1,3-dicarbonyls.Electric Literature of 10472-24-9 And the article contains the following content:

A highly efficient electrochem. α-thiolation and azidation of 1,3-dicarbonyl compounds was developed. This electrochem. process was conducted under mild conditions without the use of a chem. oxidant, and exhibits a wide scope with good functional group tolerance. The applicability of this methodol. was successfully demonstrated by modifying an anti-inflammatory drug on a gram scale. The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Electric Literature of 10472-24-9

The Article related to dicarbonyl compound electrochem alpha thiolation azidation, General Organic Chemistry: Synthetic Methods and other aspects.Electric Literature of 10472-24-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 1, 2021, Zhang, Liang; Nagaraju, Sakkani; Paplal, Banoth; Lin, Yunliang; Liu, Shuhua published an article.Computed Properties of 10472-24-9 The title of the article was Sulfonium Salts Enable the Direct Sulfenylation of Activated C(sp3)-H Bonds. And the article contained the following:

Herein, the direct α-sulfenylation of a series of β-dicarbonyl, β-ketophosphonate, and β-ketonitrile compounds, mediated by sulfonium salts has been described. Traditionally, sulfonium salts which are synthesized by activation of dialkylsulfoxides serve as oxidizing agents or precursors of sulfur ylide. In this transformation, sulfonium salts as readily prepared and operationally simple sulfenylation reagents firstly achieved alkylsulfenylation of various activated C(sp3)-H bonds with the formation of tetra-substituted carbon center. Thus, e.g., sulfenylation of Me 2-oxocyclopentanecarboxylate with DMSO in presence of AcCl as activator and NaSbF6 in MeCN afforded I (79%). The experimental process involved the reaction of Methyl 2-cyclopentanonecarboxylate(cas: 10472-24-9).Computed Properties of 10472-24-9

The Article related to sulfenylation dicarbonyl ketophosphonate ketonitrile sulfonium salt, General Organic Chemistry: Synthetic Methods and other aspects.Computed Properties of 10472-24-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics