Category: 1040281-86-4

Maier, Lukas published the artcileDiastereoselective Flexible Synthesis of Carbocyclic C-Nucleosides, Computed Properties of 1040281-86-4, the publication is Journal of Organic Chemistry (2017), 82(7), 3382-3402, database is CAplus and MEDLINE.

Carbocyclic C-nucleosides are quite rare. Our route enables flexible preparation of three classes of these nucleoside analogs from common precursors-properly substituted cyclopentanones, which can be prepared racemic (in six steps) or optically pure (in ten steps) from inexpensive norbornadiene. The methodol. allows flexible manipulation of individual positions around the cyclopentane ring, namely highly diastereoselective installation of carbo- and heterocyclic substituents at position 1′, orthogonal functionalization of position 5′, and efficient inversion of stereochem. at position 2′. Newly prepared carbocyclic C-analog of tubercidine I, profiled in MCF7 (breast cancer) and HFF1 (human foreskin fibroblasts) cell cultures, is less potent than tubercidine itself, but more selectively toxic toward the tumorigenic cells.

Journal of Organic Chemistry published new progress about 1040281-86-4. 1040281-86-4 belongs to esters-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Ester,Boronate Esters,Boronic Acids,Boronic acid and ester,Boronate Esters,, name is Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carboxylate, and the molecular formula is C12H17BO4S, Computed Properties of 1040281-86-4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Takada, Hiroyuki published the artcileIdentification of 2,6-Disubstituted 3H-Imidazo[4,5-b]pyridines as Therapeutic Agents for Dysferlinopathies through Phenotypic Screening on Patient-Derived Induced Pluripotent Stem Cells, COA of Formula: C12H17BO4S, the publication is Journal of Medicinal Chemistry (2019), 62(20), 9175-9187, database is CAplus and MEDLINE.

Dysferlinopathies, which are muscular diseases caused by mutations in the dysferlin gene, remain serious medical problems due to the lack of therapeutic agents. Herein, the authors report the design, synthesis, and structure-activity relations of a 2,6-disubstituted 3H-imidazo[4,5-b]pyridine series, which was identified from the phenotypic screening of chems. that increase the level of dysferlin in myocytes differentiated from patient-derived induced pluripotent stem cells (iPSCs). Optimization studies with cell-based phenotypic assay led to the identification of a highly potent compound, 19, with dysferlin elevation effects at double-digit nanomolar concentrations In addition, the mol. target of the authors’ chem. series was identified as tubulin, through a tubulin polymerization assay and a competitive binding assay using a photoaffinity labeling probe.

Journal of Medicinal Chemistry published new progress about 1040281-86-4. 1040281-86-4 belongs to esters-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Ester,Boronate Esters,Boronic Acids,Boronic acid and ester,Boronate Esters,, name is Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carboxylate, and the molecular formula is C13H18BClO3, COA of Formula: C12H17BO4S.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Chotana, Ghayoor A. published the artcileIridium-catalyzed borylation of thiophenes: versatile, synthetic elaboration founded on selective C-H functionalization, Recommanded Product: Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carboxylate, the publication is Tetrahedron (2008), 64(26), 6103-6114, database is CAplus and MEDLINE.

Iridium-catalyzed borylation has been applied to various substituted thiophenes to synthesize poly-functionalized thiophenes in good to excellent yields. Apart from common functionalities compatible with iridium-catalyzed borylations, addnl. functional group tolerance to acyl (COMe) and trimethylsilyl (TMS) groups was also observed High regioselectivities were observed in borylation of 3- and 2,5-di-substituted thiophenes. Electrophilic aromatic C-H/C-Si bromination on thiophene boronate esters is shown to take place without breaking the C-B bond, and one-pot C-H borylation/Suzuki-Miyaura cross-coupling has been accomplished on 2- and 3-borylated thiophenes.

Tetrahedron published new progress about 1040281-86-4. 1040281-86-4 belongs to esters-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Ester,Boronate Esters,Boronic Acids,Boronic acid and ester,Boronate Esters,, name is Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carboxylate, and the molecular formula is C12H17BO4S, Recommanded Product: Methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-3-carboxylate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics