Reference of 10328-87-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10328-87-7, name is Methyl 2,3-Dichlorophenylacetate, This compound has unique chemical properties. The synthetic route is as follows.
Step A: Preparation of Methyl 2-(2,3-dichlorophenyl)-2- methylpropanoate; [0472] A solution ofNaH (2.87 g, 71.8 mmol) in DMF (100 mL) was cooled to 00C. A solution of methyl 2-(2,3-dichlorophenyl)acetate (5.24 g, 23.9 mmol) in DMF(50 mL) was added dropwise, and the resulting mixture was stirred for 5 minutes. A solution of MeI (4.36 mL, 69.8 mmol) in DMF (50 mL) was then added to the reaction. After 10 minutes, the mixture was allowed to warm to 25C and the reaction was stirred for 16 hours. The mixture was diluted with 10% HCl(aq) (150 mL), and the resulting mixture was extracted with EtOAc (2×200 mL) and washed with 10% HCl(aq) (100 mL), deionized water (2×150 mL), and brine (100 mL). The organic layer was dried over MgSO4 and concentrated and dried in vacuo to give 7.06g crude product. The crude product was purified by flash column chromatography (silica, 0-50% DCM in hexane) to give the title compound (5.53 g). MS m/e = 247 (M+H)+.
The chemical industry reduces the impact on the environment during synthesis Methyl 2,3-Dichlorophenylacetate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; AMGEN INC.; WO2008/76427; (2008); A2;,
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