Category: 103-25-3

Martinez, AM; Hayrapetyan, D; van Lingen, T; Dyga, M; Goossen, LJ in [Martinez, Angel Manu; Hayrapetyan, Davit; van Lingen, Tim; Dyga, Marco; Goossen, Lukas J.] Ruhr Univ Bochum, Fak Chem & Biochem, Univ Str 150, D-44801 Bochum, Germany published Taking electrodecarboxylative etherification beyond Hofer-Moest using a radical C-O coupling strategy in 2020.0, Cited 75.0. Recommanded Product: Methyl 3-phenylpropionate. The Name is Methyl 3-phenylpropionate. Through research, I have a further understanding and discovery of 103-25-3.

Established electrodecarboxylative etherification protocols are based on Hofer-Moest-type reaction pathways. An oxidative decarboxylation gives rise to radicals, which are further oxidised to carbocations. This is possible only for benzylic or otherwise stabilised substrates. Here, we report the electrodecarboxylative radical-radical coupling of lithium alkylcarboxylates with 1-hydroxybenzotriazole at platinum electrodes in methanol/pyridine to afford alkyl benzotriazole ethers. The substrate scope of this electrochemical radical coupling extends to primary and secondary alkylcarboxylates. The benzotriazole products easily undergo reductive cleavage to the alcohols. They can also serve as synthetic hubs to access a wide variety of functional groups. This reaction prototype demonstrates that electrodecarboxylative C-O bond formation can be taken beyond the intrinsic substrate limitations of Hofer-Moest mechanisms.

Recommanded Product: Methyl 3-phenylpropionate. About Methyl 3-phenylpropionate, If you have any questions, you can contact Martinez, AM; Hayrapetyan, D; van Lingen, T; Dyga, M; Goossen, LJ or concate me.

Reference:
Patent; SANOFI; US2011/294788; (2011); A1;,
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An article Iron-catalyzed stereospecific arylation of enol tosylates using Grignard reagents WOS:000508933700018 published article about CROSS-COUPLING REACTIONS; SELECTIVE SYNTHESIS; ALKENYL; EFFICIENT; ALKYNES; ROBUST in [Wei, Yi-Ming; Ma, Xiao-Di; Wang, Lei; Duan, Xin-Fang] Beijing Normal Univ, Coll Chem, Beijing 100875, Peoples R China in 2020.0, Cited 56.0. The Name is Methyl 3-phenylpropionate. Through research, I have a further understanding and discovery of 103-25-3. Formula: C10H12O2

The stereospecific Fe-catalyzed arylation of enol tosylates was reported. Various tri- or tetrasubstituted Z or E-enol tosylates of beta-keto esters were arylated using common and Knochel-type Grignard reagents with complete stereofidelity. The precursors for Z/E-zimelidine, tamoxifen and other bioactive compounds were facilely prepared without precious and toxic transition metals.

Formula: C10H12O2. About Methyl 3-phenylpropionate, If you have any questions, you can contact Wei, YM; Ma, XD; Wang, L; Duan, XF or concate me.

Reference:
Patent; SANOFI; US2011/294788; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2020.0 ORG LETT published article about C-H SILYLATION; ELECTROPHILIC AROMATIC-SUBSTITUTION; BOND SILYLATION; PALLADIUM; ARYLATION; SALTS; FUNCTIONALIZATION; HETEROARENES; ACTIVATION in [Wang, Peng] Ctr Excellence Mol Synth, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China; [Wang, Peng] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Energy Regulat Mat, Shanghai 200032, Peoples R China; [Wu, Yichen; Huang, Yu-Hao; Chen, Xiao-Yue] Chinese Acad Sci, Shanghai Inst Organ Chem, Ctr Excellence Mol Synth, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China in 2020.0, Cited 68.0. The Name is Methyl 3-phenylpropionate. Through research, I have a further understanding and discovery of 103-25-3. Quality Control of Methyl 3-phenylpropionate

The thianthrene S-oxide (TTSO)-mediated site-selective silylation of arenes has been realized via a thianthrenation/Pd-catalyzed silylation sequence. This method features a broad substrate scope and wide functional group tolerance under mild conditions and allows the synthesis of a set of (hetero)arylsilanes with operationally simple manipulations. The application and generality of the approach were further demonstrated by the late-stage functionalization of marketed drugs. This reaction also represents the first example of a Pd-catalyzed silylation reaction of aryl sulfonium salts.

Quality Control of Methyl 3-phenylpropionate. About Methyl 3-phenylpropionate, If you have any questions, you can contact Wu, YC; Huang, YH; Chen, XY; Wang, P or concate me.

Reference:
Patent; SANOFI; US2011/294788; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Recently I am researching about C-H BONDS; ELECTRON-TRANSFER OXIDATION; ALKYL RADICALS; COMPLEXES; ANION; FUNCTIONALIZATION; DERIVATIVES; MECHANISM; DISCOVERY; LIGANDS, Saw an article supported by the National Institute of General Medical Sciences (NIGMS), the NIH [R01 GM078201-05]; Princeton University, E. Taylor and the Taylor family. Computed Properties of C10H12O2. Published in NATURE PUBLISHING GROUP in LONDON ,Authors: Sarver, PJ; Bacauanu, V; Schultz, DM; DiRocco, DA; Lam, YH; Sherer, EC; MacMillan, DWC. The CAS is 103-25-3. Through research, I have a further understanding and discovery of Methyl 3-phenylpropionate

The introduction of a trifluoromethyl (CF3) group can dramatically improve a compound’s biological properties. Despite the well-established importance of trifluoromethylated compounds, general methods for the trifluoromethylation of alkyl C-H bonds remain elusive. Here we report the development of a dual-catalytic C(sp(3))-H trifluoromethylation through the merger of light-driven, decatungstate-catalysed hydrogen atom transfer and copper catalysis. This metallaphotoredox methodology enables the direct conversion of both strong aliphatic and benzylic C-H bonds into the corresponding C(sp(3))-CF3 products in a single step using a bench-stable, commercially available trifluoromethylation reagent. The reaction requires only a single equivalent of substrate and proceeds with excellent selectivity for positions distal to unprotected amines. To demonstrate the utility of this new methodology for late-stage functionalization, we have directly derivatized a broad range of approved drugs and natural products to generate valuable trifluoromethylated analogues. Preliminary mechanistic experiments reveal that a ‘Cu-CF3’ species is formed during this process and the critical C(sp(3))-CF3 bond-forming step involves the copper catalyst.

About Methyl 3-phenylpropionate, If you have any questions, you can contact Sarver, PJ; Bacauanu, V; Schultz, DM; DiRocco, DA; Lam, YH; Sherer, EC; MacMillan, DWC or concate me.. Computed Properties of C10H12O2

Reference:
Patent; SANOFI; US2011/294788; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

An article Vicinal Diboration of Alkyl Bromides via Tandem Catalysis WOS:000471212100090 published article about ALKYLBORONIC ESTERS; BOND FORMATION; BORYLATION; SECONDARY; SUBSTITUTION; CONSTRUCTION; ACTIVATION; ALKENES; HALIDES in [Wang, Xiao-Xu; Li, Lei; Gong, Tian Jun; Xiao, Bin; Lu, Xi; Fuo, Yao] Univ Sci & Technol China, iChEM, Anhui Prov Key Lab Biomass Clean Energy, Hefei Natl Lab Phys Sci Microscale,CAS Key Lab Ur, Hefei 230026, Anhui, Peoples R China in 2019.0, Cited 62.0. The Name is Methyl 3-phenylpropionate. Through research, I have a further understanding and discovery of 103-25-3. Recommanded Product: 103-25-3

Vicinal diboration of alkyl bromides via tandem catalysis is reported. The reported reaction exhibits a broad substrate scope, good functional group compatibility, and regioselectivity. Moreover, it shows good practicality due to the easy accessibility of alkyl bromides in combination with diverse transformations of diboronates. Mechanism study indicates that terminal alkenes are generated selectively through nickel-catalyzed dehydrohalogenation of alkyl bromides followed by base/MeOH promoted diboration process to provide 1,2-diboration products.

Recommanded Product: 103-25-3. About Methyl 3-phenylpropionate, If you have any questions, you can contact Wang, XX; Li, L; Gong, TJ; Xiao, B; Lu, X; Fuo, Y or concate me.

Reference:
Patent; SANOFI; US2011/294788; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 103-25-3, name is Methyl 3-phenylpropionate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 103-25-3, Computed Properties of C10H12O2

In the 10mL single-mouth bottle,Nitrogen protection,82.1 mg (0.50 mmol) of compound 1e is added,2.5mL n-pentane,105.9 mg (2.25 mmol) deuterated ethanol (EtOD),16.0 mg (2.25 mmol) lithium block,Stir for 5 min at 0C.Rise to room temperatureThe reaction was quenched with 3.0 M aqueous hydrochloric acid.Add ether and saturated salt,59.0 mg of target compound 4a was obtained.Yield 85%.

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Reference:
Patent; China Agricultural University; An Jie; Lei Peng; Han Minhui; Ma Xiaodong; Wu Yufei; A Dila·adijiang; Ding Yuxuan; (15 pag.)CN107445798; (2017); A;,
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Related Products of 103-25-3, A common heterocyclic compound, 103-25-3, name is Methyl 3-phenylpropionate, molecular formula is C10H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

27.1. methyl 2-benzyl-3-oxopropanoate To a mixture of 3 g (18.3 mmol) of methyl 3-phenylpropanoate and 3.57 mL (54.8 mmol) of methyl formate in 36 mL of toluene, under argon, are added dropwise successively 54.8 mL (54.8 mmol) of a 1 M solution of TiCl4 in toluene, 0.17 mL (0.91 mmol) of trimethylsilyl trifluoromethanesulfonate and 19.6 mL (82.2 mmol) of tributylamine. The medium is then heated for 2 hours 30 minutes at 60 C. and stirred for 12 hours at room temperature. The reaction medium is hydrolysed with 200 mL of water and extracted with 200 mL of Et2O. The organic phase is dried over Na2SO4, filtered and concentrated under reduced pressure. 3.12 g of methyl 2-benzyl-3-oxopropanoate are obtained in the form of an oil, which is used without further purification in the following step. Yield=87%

The synthetic route of 103-25-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SANOFI; US2011/294788; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 103-25-3, name is Methyl 3-phenylpropionate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C10H12O2

Several other esters, whose structure and names are described in Table 3, were hydro genated under the conditions described above using preformed RuCl2(L-I). Isolated yield are given in Table 4.Table 3: Structure and names of substrates usedTable 4: Hydrogenation of esters using RuCl2(L-I) EPO Sub.: Substrate as described in Table 3.Conv.: Conversion (in %, analysed by GC after silylation) of ester to alcohol after 2h30min.Reaction conditions: Substrate (20 mmol), H2 gas (50 bars), RuCl2(L-I) 0.05 mol%,NaOMe 10 mol%, THF (14 mL) at 1000C during 2h 30min.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 103-25-3.

Reference:
Patent; FIRMENICH SA; WO2006/106484; (2006); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Some common heterocyclic compound, 103-25-3, name is Methyl 3-phenylpropionate, molecular formula is C10H12O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C10H12O2

General procedure: A mixture of Lithium aluminum hydride (9.5 g, 0.250 mol), dry THF(250 mL), to it add substituted dihydrocinnamic acid methyl ester (3ae,0.127 mol), in THF (50 mL) was added slowly drop wise during30 min. After completion of addition the reaction mixture was stirredfor 2 h at rt, after completion of reaction as monitored by TLC hexane/ethyl acetate (8:2), the reaction mixture was poured in water (200 mL),acidified with 5 N HCl, extract with chloroform (2¡Á400 mL), extractwas wash with water, brine solution, dried over Na2SO4 and concentrated.The crude residue was subjected to column chromatographyon silica gel, column was eluted with hexane/ethyl acetate mixtures,pure compound was eluted in ethyl acetate in hexane, 10%/90% (v/v)which was monitored by TLC, pure fractions were combined and concentratedto obtained 3-(substituted phenyl)- propan-1-ol as oily compoundswith yields of 73-77%. 3.2.13 3-(Phenyl)-propan-1-ol (4a) Weight: 9.10?g; % yield: 73.2%; 1H NMR (CDCl3, 400?MHz): delta 7.32-7.28 (2H, m, H-3′, 5′), 7.14 (2H, d, J?=?8.0?Hz, H-2′, 6′), 7.06 (1H, t, J?=?7.2?Hz, H-4′), 3.56 (2H, t, J?=?8.0?Hz, CH2), 2.56 (2H, t, J?=?7.2?Hz, H-3), 2.43 (1H, s, OH), 1.86 (2H, quin, J?=?7.6?Hz, H-2); 13C NMR (CDCl3, 100?MHz): delta 146.2 (C-1′), 132.8 (C-3′, 5′), 130.2 (C-2′, 6′), 126.8 (C-4′), 65.8 (C-1), 38.3 (C-2), 31.9 (C-3); LC-MS: m/z 135.2 (M?-?H)-.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 103-25-3, its application will become more common.

Reference:
Article; Meka, Bharani; Ravada, Suryachandra Rao; Muthyala, Murali Krishna Kumar; Kurre, Purna Nagasree; Golakoti, Trimurtulu; Bioorganic Chemistry; vol. 80; (2018); p. 408 – 421;,
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