Category: 103-09-3

Chemotherapy-induced cognitive dysfunction (chemobrain) is one of the major complaints for cancer patients treated with chemotherapy such as Doxorubicin (DOX). The induction of oxidative stress and neuroinflammation were identified as major contributors to such adverse effect. Caffeic acid phenethyl ester (CAPE) is a natural polyphenolic compound, that exhibits unique context-dependent antioxidant activity. It exhibits pro-oxidant effects in cancer cells, while it is a potent antioxidant and cytoprotective in normal cells. The present study was designed to investigate the potential neuroprotective effects of CAPE against DOX-induced cognitive impairment. Chemobrain was induced in Sprague Dawley rats via systemic DOX administration once per week for 4 weeks (2 mg/kg/week, i.p.). CAPE was administered at 10 or 20 mu mol/kg/day, i.p., 5 days per week for 4 weeks. Morris water maze (MWM) and passive avoidance tests were used to assess learning and memory functions. Oxidative stress was evaluated via the colorimetric determination of GSH and MDA levels in both hippocampal and prefrontal cortex brain regions. However, inflammatory markers, acetylcholine levels, and neuronal cell apoptosis were assessed in the same brain areas using immunoassays including either ELISA, western blotting or immunohistochemistry. DOX produced significant impairment in learning and memory as indicated by the data generated from MWM and step-through passive avoidance tests. Additionally DOXtriggered oxidative stress as evidenced from the reduction in GSH levels and increased lipid peroxidation. Treatment with DOX resulted in neuroinflammation as indicated by the increase in NF-kB (p65) nuclear translocation in addition to boosting the levels of pro-inflammatory mediators (COX-II/TNF-alpha) along with the increased levels of glial fibrillary acid protein (GFAP) in the tested tissues. Moreover, DOX reduced acetylcholine levels and augmented neuronal cell apoptosis as supported by the increased active caspase-3 levels. Co-treatment with CAPE significantly counteracted DOX-induced behavioral and molecular abnormalities in rat brain tissues. Our results provide the first preclinical evidence for CAPE promising neuroprotective activity against DOXinduced neurodegeneration and memory deficits.

If you are hungry for even more, make sure to check my other article about 103-09-3, Quality Control of 2-Ethylhexyl acetate.

Reference:
Ester – Wikipedia,
,Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 103-09-3, name is 2-Ethylhexyl acetate, A new synthetic method of this compound is introduced below., Safety of 2-Ethylhexyl acetate

In the mechanical stirrer, reflux condenser and a thermometer of the 1000 ml flask of three sequentially added in the methyl acetate 296 g, isooctanol 260 g toluene sulfonic acid and 13.0 g, stir, for 65 C reaction 4 hours. By reducing pressure low boiling, then adding to the methoxy benzaldehyde 180 g, dropping 30% of 36 g liquid sodium methoxide. The reaction temperature is raised to 90 C, reaction 4 hours later. Gradually adding glacial acetic acid 7.9 g out-in and. By reducing pressure low boiling, filtering to remove the mother liquor solids, then the gas phase chromatography analysis, calculated in the mother liquor to the methoxy cinnamic acid ester product 376 g, yield 98.2%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Shandong Daguan Biochemical Technology Co., Ltd.; Qingdao University of Science and Technology; Zhang Yongfu; Liu Baowei; Xu Zhihua; Jiang Yunbing; Yang Fengke; (6 pag.)CN107522616; (2017); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 103-09-3, name is 2-Ethylhexyl acetate, A new synthetic method of this compound is introduced below., HPLC of Formula: C10H20O2

In the mechanical stirrer, reflux condenser and a thermometer of the 1000 ml flask of three sequentially added in the methyl acetate 296 g, isooctanol 260 g toluene sulfonic acid and 13.0 g, stir, for 65 C reaction 4 hours. By reducing pressure low boiling, then adding to the methoxy benzaldehyde 180 g, dropping 30% of 36 g liquid sodium methoxide. The reaction temperature is raised to 90 C, reaction 4 hours later. Gradually adding glacial acetic acid 7.9 g out-in and. By reducing pressure low boiling, filtering to remove the mother liquor solids, then the gas phase chromatography analysis, calculated in the mother liquor to the methoxy cinnamic acid ester product 376 g, yield 98.2%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Shandong Daguan Biochemical Technology Co., Ltd.; Qingdao University of Science and Technology; Zhang Yongfu; Liu Baowei; Xu Zhihua; Jiang Yunbing; Yang Fengke; (6 pag.)CN107522616; (2017); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 103-09-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 103-09-3 name is 2-Ethylhexyl acetate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Reduce the temperature to 20-25 C, add 39.5kg (0.73kmol) of sodium methoxide solid, start stirring, control the temperature of the kettle at 20-25 C, and add 93.8kg (0.69kmol) of p-methoxybenzaldehyde dropwise within 30min. the temperature was raised to 110 C until the GC content of p-methoxybenzaldehyde was less than 0.25%. It takes about 1h.After the reaction is completed, water is added to the reaction system, stirred, left to stand, and separated into layers.An aqueous layer and an organic layer were obtained. Washing the organic layer to separate the aqueous layer,Obtain a washed organic layer, rectifying the organic layer, the yield of isooctyl p-methoxycinnamate was 183.0 kg (0.63 kmol), and the yield was 91.5%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Ethylhexyl acetate, and friends who are interested can also refer to it.

Reference:
Patent; Anhui Shengnuobei Chemical Technology Co., Ltd.; Liu Qifa; Wang Rong; Yang Jian; Wang Zhongxiao; Li Juan; (12 pag.)CN110540505; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 103-09-3, Name is 2-Ethylhexyl acetate, molecular formula is C10H20O2. In an article, author is Bankura, Abhijit,once mentioned of 103-09-3, Safety of 2-Ethylhexyl acetate.

Non-Bonding 1,4-Sulphur-Oxygen Interaction Governs the Reactivity of alpha-Ketothioesters in Triphenylphosphine-Catalyzed Cyclization with Acetylenedicarboxylates

alpha-Ketothioesters undergo triphenylphosphine (PPh3)-catalyzed cyclization with acetylenedicarboxylate esters smoothly, in contrast to alpha-ketooxoesters which require more drastic conditions with the limited substrate scope. The reaction works well with a wide range of alpha-ketothioesters, delivering highly functionalized alpha,beta-unsaturated gamma-butyrolactones in moderate to excellent yields. The higher reactivity of the thioester derivatives is seemingly due to a favourable intramolecular non-bonding electrostatic 1,4-interaction involving C-S sigma* orbital on the sulphur atom and the lone pair of electrons in the electron-donating oxygen atom. This is apparent from the X-ray crystallographically determined internuclear distance between the sulphur and ketone (C=O) oxygen atoms (2.71-2.85 angstrom), which is significantly less than the sum of their van der Waals radii (3.25-3.30 angstrom). The substitution on the S atom is oriented diametrically away from the ketone O atom to maximize the interaction between them. The trend is also seen in the 1,4-S…O contact between the S and furan O atoms (2.70 angstrom) in the gamma-butyrolactone products.

Interested yet? Keep reading other articles of 103-09-3, you can contact me at any time and look forward to more communication. Safety of 2-Ethylhexyl acetate.

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Tao, Pan, once mentioned the application of 103-09-3, Name is 2-Ethylhexyl acetate, molecular formula is C10H20O2, molecular weight is 172.27, MDL number is MFCD00027249, category is esters-buliding-blocks. Now introduce a scientific discovery about this category, Safety of 2-Ethylhexyl acetate.

Enhanced performance of rosin-based epoxy composites mixed with carbon nanotubes and cork powders from oriental oak bark

Rosin-based epoxy composites with high-impact toughness, tensile strength, modulus, and excellent flame retardance were prepared through a simple and effective approach. In this study, rosin-based epoxy resin (acrylopimaric diglycidyl ester, APA-ER) was synthesized from rosin, and the chemical structures of the products were determined by H-1 NMR and FT-IR. The multiwalled carbon nanotubes (MWCNTs) and cork powders were introduced to the APA-ER to enhance the mechanical and thermal properties of epoxy composites. For the first time, cork powder was used to reinforce the modified rosin-based epoxy resin. Testing results of the mechanical properties indicated that the impact toughness of epoxy composite with 1.5 wt% MWCNTs and 3 wt% cork powders (100-200 mesh) had the highest value (12.34 and 12.04 kJ m(-2)), which was increased by 324% and 314%, respectively, compared to pure resin (2.91 kJ m(-2)). The composites with 1.5 wt% MWCNTs displayed better flexural and tensile performance compared to APA-ER/Cork. Moreover, the DMA, TG, and cone calorimeter results showed that APA-ER/Cork had a better performance in thermal stability and flame retardance than APA-ER/MWCNTs. Additionally, the flame retardance of rosin-based epoxy resin was further improved by adding MWCNTs and cork powder simultaneously. These results showed that the rosin-based epoxy resin could be toughened and strengthened effectively, and the thermal performance was improved by MWCNTs and cork powders. In conclusion, the value-added development of rosin and cork products was increased and applied in the field of functional materials.

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Synthetic Route of 103-09-3, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 103-09-3, Name is 2-Ethylhexyl acetate, SMILES is CC(OCC(CC)CCCC)=O, belongs to esters-buliding-blocks compound. In a article, author is Becker, Kevin, introduce new discover of the category.

Hybridorubrins A-D: Azaphilone Heterodimers from Stromata of Hypoxylon fragiforme and Insights into the Biosynthetic Machinery for Azaphilone Diversification

The diversity of azaphilones in stromatal extracts of the fungus Hypoxylon fragiforme was investigated and linked to their biosynthetic machineries by using bioinformatics. Nineteen azaphilone-type compounds were isolated and characterized by NMR spectroscopy and mass spectrometry, and their absolute stereoconfigurations were assigned by using Mosher ester analysis and electronic circular dichroism spectroscopy. Four unprecedented bis-azaphilones, named hybridorubrins A-D, were elucidated, in addition to new fragirubrins F and G and various known mitorubrin derivatives. Only the hybridorubrins, which are composed of mitorubrin and fragirubrin moieties, exhibited strong inhibition of Staphylococcus aureus biofilm formation. Analysis of the genome of H. fragiforme revealed the presence of two separate biosynthetic gene clusters (BGCs) hfaza1 and hfaza2 responsible for azaphilone formation. While the hfaza1 BGC likely encodes the assembly of the backbone and addition of fatty acid moieties to yield the (R)-configured series of fragirubrins, the hfaza2 BGC contains the necessary genes to synthesise the widely distributed (S)-mitorubrins. This study is the first example of two distant cross-acting fungal BGCs collaborating to produce two families of azaphilones and bis-azaphilones derived therefrom.

Synthetic Route of 103-09-3, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 103-09-3.

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Brunner, Felix M., once mentioned the application of 103-09-3, Name is 2-Ethylhexyl acetate, molecular formula is C10H20O2, molecular weight is 172.27, MDL number is MFCD00027249, category is esters-buliding-blocks. Now introduce a scientific discovery about this category, Quality Control of 2-Ethylhexyl acetate.

Investigation of Immobilization Effects on Ni(P2N2)(2) Electrocatalysts

A new synthetic route to complexes of the type Ni(P2N2)(2)(2+) with highly functionalized phosphine substituents and the investigation of immobilization effects on these catalysts is reported. Ni(P2N2)(2)(2+ )complexes have been extensively studied as homogeneous and surface-attached molecular electrocatalysts for the hydrogen evolution reaction (HER). A synthesis based on postsynthetic modification of (P2N2PH)-N-ArBr was developed and is described here. Phosphonate-modified ligands and their corresponding nickel complexes were isolated and characterized. Subsequent deprotection of the phosphonic ester derivatives provided the first Ni(P2N2)(2)2+ catalyst that can be covalently attached via pendent phosphonate groups to an electrode without involvement of the important pendent amine groups. Mesoporous TiO2 electrodes were surface modified by attachment of the new phosphonate functionalized Ni(P2N2)(2)2+ complexes, and these provided electrocatalytic materials that proved to be competent and stable for sustained HER in aqueous solution at mild pH and low overpotential. We directly compared the new ligand to a previously reported complex that utilized the amine moiety for surface attachment. Using HER as the benchmark reaction, the P-attached catalyst showed a marginally (9-14%) higher turnover number than its N-attached counterpart.

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Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.103-09-3, Name is 2-Ethylhexyl acetate, SMILES is CC(OCC(CC)CCCC)=O, belongs to esters-buliding-blocks compound. In a document, author is Chang, Zhaosen, introduce the new discover, Application In Synthesis of 2-Ethylhexyl acetate.

A novel fluorescent covalent organic framework containing boric acid groups for selective capture and sensing of cis-diol molecules

Owing to specific formation of five-membered or six-membered cyclic esters between boric acid groups and cis-diol molecules, boric acid bearing fluorescent materials can not only selectively capture but also specifically identify cis-diol substances. In this work, a novel covalent organic framework containing boric acid groups (COF-BA) was prepared through post-modification via the aza-Diels-Alder cycloaddition reaction. COF-BA with good stability, a permanent pore structure, a high specific surface area (606 m(2) g(-1)) and a uniform pore size (2.59 nm) exhibited unique selectivity toward the cis-diol guest molecule 1,2-dihydroxyanthracene-9,10-dione (1,2-Doa) with a high adsorption capacity of 177.95 mg g(-1). However, as for the isomers of 1,2-Doa (1,4-dihydroxyanthracene-9,10-dione and 2,6-dihydroxyanthracene-9,10-dione), the corresponding uptake capacities are distinctively decreased to 40.86 mg g(-1) and 3.05 mg g(-1), respectively. It is worth noting that the COF-BA can be recovered and recycled. Moreover, because the formation of the quinoline enhanced the conjugation effect of the COF skeleton, it was unexpectedly found that COF-BA possessed an intrinsic fluorescence property and could be used as an optical sensor for 1,2-Doa.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 103-09-3 is helpful to your research. Application In Synthesis of 2-Ethylhexyl acetate.

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 103-09-3, Name is 2-Ethylhexyl acetate, molecular formula is C10H20O2, belongs to esters-buliding-blocks compound, is a common compound. In a patnet, author is Zhang, Yuxia, once mentioned the new application about 103-09-3, SDS of cas: 103-09-3.

Carbene-Catalyzed Enantioselective Synthesis of gamma-Keto-beta-silyl Esters and Amides

A variety of gamma-keto-beta-silyl esters and amides, most with extremely high enantioselectivities, were efficiently prepared via a carbene-catalyzed formal [4 + 2] annulation followed by ring opening with nucleophiles. The resulting compounds from this one-pot strategy can be easily converted into enantioenriched beta,sigma-dihydroxyl esters.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 103-09-3. The above is the message from the blog manager. SDS of cas: 103-09-3.