Category: 10203-58-4

Optically active N- and C-terminal building blocks for the synthesis of peptidyl olefin peptidomimetics was written by Mirilashvili, Sima;Chasid-Rubinstein, Naama;Albeck, Amnon. And the article was included in European Journal of Organic Chemistry in 2010.Recommanded Product: 10203-58-4 This article mentions the following:

Peptidyl olefin peptidomimetics serve as biol. active compounds or as intermediates for other peptidyl isosteres. The N-terminal side of the C:C bond could be easily prepared in an optically pure form from 浼?amino acids. Synthesis of C-terminal building blocks in an optically pure form is more challenging. They include an electrophilic aldehyde and nucleophilic sulfone, phosphonium salt, phosphonate, and diselenide. Key enzymic hydrolysis of prochiral diesters to the corresponding hydroxy esters introduces optical activity. The sequence of the subsequent chem. reactions, either protection-hydrolysis-functionalization or functionalization-hydrolysis-protection, determines the absolute stereochem. of the final building blocks. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4Recommanded Product: 10203-58-4).

Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 10203-58-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ruthenium-catalyzed benzylic substitution of benzyl esters with stabilized carbon nucleophiles was written by Suzuki, Koki;Tsuji, Hiroaki;Kawatsura, Motoi. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.Recommanded Product: Diethyl isobutylmalonate This article mentions the following:

A [Cp*RuCl₂]₂/picolinic acid catalyst system promoted the reaction of 2-naphthylmethyl-2,3,4,5,6-pentafluorobenzoates with a series of stabilized carbon nucleophiles such as malonates, 灏?ketoesters, and diketones to give the corresponding benzylic alkylation products in moderate to high yields. A plausible reaction mechanism that could involve a (锜?benzyl)ruthenium intermediate is proposed. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4Recommanded Product: Diethyl isobutylmalonate).

Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Recommanded Product: Diethyl isobutylmalonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mixed dialkylaluminum chlorides and mixed trimethylorganoaluminates in chemoselective 1,4-addition reactions to alkylidene malonic acid diethyl ester was written by Maas, Steffen;Kunz, Horst. And the article was included in Journal fuer Praktische Chemie (Weinheim, Germany) in 2000.Application of 10203-58-4 This article mentions the following:

Mixed (alkyl)methylaluminum chlorides (aryl)methylaluminum chlorides were formed by reaction of methylaluminum dichloride with organolithium or Grignard compounds and used for chemoselective 1,4-addition of higher alkyl, aryl, alkenyl and alkynyl groups to (alkylidene)propanedioates. Such aluminum reagents were prepared in situ; for example: (butyl)methylaluminum chloride, lithium butyltrimethylaluminate(1-), chloro(1-hexynyl)methylaluminum, chloro(ethenyl)methylaluminum. As an alternative, mixed trimethylorganoaluminates can also be applied for these Michael addition reactions. For conjugate addition of alkenyl groups to (alkylidene)propanedioates, alkenyl diisopropylalanes obtained from alkynes and diisopropylaluminum hydride proved the most efficient reagents. Using these novel mixed organoaluminum compounds, 灏?branched malonic (carboxylic) acid derivatives were obtained in good yields. The method offers a general access to 灏?branched carboxylic derivatives of quite diverse structure not dependent on the com. availability of the organoaluminum chlorides. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4Application of 10203-58-4).

Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Application of 10203-58-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Malonic ester and acetoacetic ester synthesis of 2-[^11,14C]methyl-fatty acids was written by Ogawa, Koji;Sasaki, Motiji;Nozaki, Tadashi. And the article was included in Applied Radiation and Isotopes in 1997.Synthetic Route of C11H20O4 This article mentions the following:

Suitable conditions were sought for the synthesis of various 2-[^11,14C]methyl-fatty acids by malonic ester synthesis and acetoacetic ester synthesis, both involving radio-methylation with [^11,14C]H₃I. The malonic ester synthesis gave 2-[¹¹C]methyl-fatty acids with >60% decay-corrected yields in 閳?0 min and the [¹⁴C] products with somewhat higher yields at longer time. In the acetoacetic ester synthesis, several 2-[¹⁴C]methyl-fatty acids were synthesized in 50-70% yields, together with byproduct ketones, by hydrolysis of the radiomethylated acetoacetates with concentrated KOH solution. This hydrolysis was completed in 5 min at 70鎺? whereas rather drastic conditions or a longer time were needed for the thermal decarboxylation in the malonic ester synthesis. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4Synthetic Route of C11H20O4).

Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Synthetic Route of C11H20O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Conjugate addition of dialkylaluminum chlorides to alkylidenemalonic acid derivatives was written by Maas, Steffen;Stamm, Armin;Kunz, Horst. And the article was included in Synthesis in 1999.Related Products of 10203-58-4 This article mentions the following:

Complete regioselectivity is achieved in conjugate addition of dialkylaluminum chlorides with alkylidenemalonic esters, alkylidenecyanoacetates, and alkylidenemalononitrile to give 灏?branched carboxylate derivatives Sterically demanding products containing quaternary C atoms are obtained in good yields. In the case of Et₂AlCl, accompanying reduction of the substrates can be suppressed by application of BF₃ as an assisting Lewis acid. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4Related Products of 10203-58-4).

Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is 绾?valerolactone.Related Products of 10203-58-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Design, synthesis and antimalarial activity of novel, quinoline-Based, zinc metallo-aminopeptidase inhibitors was written by Flipo, Marian;Florent, Isabelle;Grellier, Philippe;Sergheraert, Christian;Deprez-Poulain, Rebecca. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2003.Recommanded Product: Diethyl isobutylmalonate This article mentions the following:

PfA-M1, a neutral zinc aminopeptidase of Plasmodium falciparum, is a new potential target for the discovery of antimalarials. The design and synthesis of a library of 45 quinoline-based inhibitors of PfA-M1 is reported. The best inhibitor displays an IC₅₀ of 854 nM. The antimalarial activity on a CQ-resistant strain and the specificity towards mammalian aminopeptidase N are also discussed. Compounds thus prepared and evaluated included N¹-hydroxy-N²-(2-methylpropyl)-N²-(4-quinolinyl)propanediamide, N¹-hydroxy-N²,2-bis(2-methylpropyl)-N²-(4-quinolinyl)propanediamide and 2-amino-N¹-hydroxy-N²-(2-methylpropyl)-N²-(4-quinolinyl)propanediamide. These compounds were analogs of N-(cyclopropylmethyl)-N-(4-quinolinyl)-β-alaninamide. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4Recommanded Product: Diethyl isobutylmalonate).

Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Recommanded Product: Diethyl isobutylmalonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Direct catalytic asymmetric Mannich reactions of malonates and β-keto esters was written by Marigo, Mauro;Kjaersgaard, Anne;Juhl, Karsten;Gathergood, Nicholas;Jorgensen, Karl Anker. And the article was included in Chemistry – A European Journal in 2003.Computed Properties of C11H20O4 This article mentions the following:

The first catalytic asym. direct Mannich reaction of malonates and β-keto esters has been developed. Malonates react with an activated N-tosyl-α-imino ester catalyzed by chiral tert-butyl-bisoxazoline/Cu(OTf)₂ to give the Mannich adducts in high yields and with up to 96% ee. These reactions create a chiral quaternary carbon center and it is demonstrated that this new direct Mannich reactions provides for example a new synthetic procedure for the formation of optically active β-carboxylic ester α-amino acid derivatives A series of different β-keto esters with various ester substituents has been screened as substrates for the catalytic asym. direct Mannich reaction and it was found that the best results in terms of yield, diastereo- and enantioselectivity were obtained when tert-Bu esters of β-keto esters were used as the substrate. The reaction of different β-keto tert-Bu esters with the N-tosyl-α-imino ester gave the Mannich adducts in high yields, diastereo- and enantioselectivities (up to 95% ee) in the presence of chiral tert-butyl-bisoxazoline/Cu(OTf)₂ as the catalyst. To expand the synthetic utility of this direct Mannich reaction, a diastereoselective decarboxylation reaction was developed for the Mannich adducts leading to a new synthetic approach to attractive optically active β-keto α-amino acid derivatives Based on the stereochem. outcome of the reactions, various approaches of the N-tosyl-α-imino ester to the chiral bisoxazoline/Cu^II-substrate intermediate are discussed. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4Computed Properties of C11H20O4).

Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Computed Properties of C11H20O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Competition between the β-hydroxylation of a primary and a tertiary carbon atom in rats was written by Moubarik, Soumaya Chraibi-Ben;Menager, Sabine;Lafont, Olivier. And the article was included in European Journal of Medicinal Chemistry in 2000.Name: Diethyl isobutylmalonate This article mentions the following:

In order to study the effect of steric hindrance on competition between two kinds of β-hydroxylation, a compound bearing on a pyrimidinetrione nucleus both a branched side chain with a tertiary carbon atom in position β (iso-Bu group) and a linear side chain (Et group), was selected and administered to rats. Urine and feces were collected and extracted Hydroxymetabolites and their derivatives were isolated and then identified. The β-hydroxylation of the linear chain was more important than the β-hydroxylation of the branched chain. Steric hindrance plays a decisive role in this regioselectivity. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4Name: Diethyl isobutylmalonate).

Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Name: Diethyl isobutylmalonate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Parahydrophobic Surfaces Made of Intrinsically Hydrophilic PProDOT Nanofibers with Branched Alkyl Chains was written by Mortier, Claudio;Darmanin, Thierry;Guittard, Frederic. And the article was included in Advanced Engineering Materials in 2014.HPLC of Formula: 10203-58-4 This article mentions the following:

We report the synthesis of original 3,4-ethylenedioxythiophene (ProDOT) derivatives containing a branched alkyl chain of various sizes and used as monomers for the formation of parahydrophobic (high apparent contact and high sliding angle) nanofibers by electropolymerization In this work, the size of the branched alkyl chain do not have a significant influence on the surface morphol. because the intrinsic hydrophobicity of the polymers is quite the same. Indeed, assemblies of long polymer nanofibers forming micro- and nanoporous structures are obtained for each polymer. These surfaces display also very high adhesion of water droplets. Indeed, the penetration of water droplets inside the surface roughness was important due to the presence of these nanofibrous structures and the intrinsically hydrophilicity of the polymers. Such materials are excellent candidates for biosensors or anti-bioadhesion. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4HPLC of Formula: 10203-58-4).

Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.HPLC of Formula: 10203-58-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Creation through Immobilization: A New Family of High Performance Heterogeneous Bifunctional Iminophosphorane (BIMP) Superbase Organocatalysts was written by Goldys, Anna M.;Nunez, Marta G.;Dixon, Darren J.. And the article was included in Organic Letters in 2014.SDS of cas: 10203-58-4 This article mentions the following:

An immobilized chiral bifunctional iminophosphorane superbase organocatalyst I has been developed and applied in a range of challenging enantioselective reactions. A unique feature of this novel catalytic system is that the final step creation of the iminophosphorane occurs at the point of immobilization. The utility of the immobilized catalyst system was demonstrated in the nitro-Mannich reaction of ketimines as well as the conjugate addition of high pK_a 1,3-dicarbonyl pro-nucleophiles to nitrostyrene. Catalyst recycling was also demonstrated. In the experiment, the researchers used many compounds, for example, Diethyl isobutylmalonate (cas: 10203-58-4SDS of cas: 10203-58-4).

Diethyl isobutylmalonate (cas: 10203-58-4) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.SDS of cas: 10203-58-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics