Category: 101-97-3

Adding a certain compound to certain chemical reactions, such as: 101-97-3, name is Ethyl 2-phenylacetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 101-97-3, Formula: C10H12O2

(1′-Ethoxycarbonyl-1′-methyl)ethylbenzene To a solution of ethyl phenylacetate (32.8 g, 200 mmol) in THF (1000 mL) under argon was added sodium bistrimethylsilylamide (2M in THF, 100 mL). After 45 minutes. methyl iodide (13 mL) was added over 15 minutes and the mixture was stirred at rt for 30 minutes. Additional sodium bistrimethylsilylamide (2M in THF, 100 mL) was added, followed, after 30 minutes, by methyl iodide (14 mL). After 30 minutes the mixture was diluted with hexane and washed with water. The organic phase was dried, filtered and evaporated to give (1′-ethoxycarbonyl-1′-methyl)ethylbenzene (28.0 g, 146 mmol, 73%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Boehringer Ingelheim Pharmaceuticals, Inc.; US6156784; (2000); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 101-97-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 101-97-3, name is Ethyl 2-phenylacetate, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of ethyl phenylacetate (32.8 g, 200 mmol) in THF (tetrahydrofurane) (1000 mL) under argon was added sodium bistrimethylsilylamide (2M in THF, 100 mL). After 45 minutes, methyl iodide (13 mL) was added over 15 minutes and the mixture was stirred at rt (room temperature) for 30 minutes. Additional sodium bistrimethylsilylamide (2M in THF, 100 mL) was added, followed, after 30 minutes, by methyl iodide (14 mL). After 30 minutes the mixture was diluted with hexane and washed with water. The organic phase was dried, filtered and evaporated to give (1′-ethoxycarbonyl-1′-methyl)ethylbenzene (28.0 g, 146 mmol, 73%).

The chemical industry reduces the impact on the environment during synthesis Ethyl 2-phenylacetate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Boehringer Ingelheim Pharmaceuticals, Inc.; EP1171113; (2004); B1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics