Category: 10076-48-9

Electric Literature of 10076-48-9,Some common heterocyclic compound, 10076-48-9, name is Methyl 2,2-dimethoxypropanoate, molecular formula is C6H12O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 14 Methyl 2-cinnamyloxyiminopropionate 2.8 g. (15 mmol) O-cinnamylhydroxylamine hydrochloride in 20 ml. water are added to 2.8 g. (19 mmol) methyl 2,2-dimethoxypropionate in 100 ml. water. The mixture is left to stand for 2 days, with occasional shaking, and the resultant oil then extracted with methylene chloride. The extracts are dried and evaporated. As residue, there are obtained 3.3 g. (94% of theory) methyl 2-cinnamyloxyiminopropionate in the form of a colorless oil. The ester can be saponified with a methanolic solution of potassium hydroxide to give 2-cinnamyloxyiminopropionic acid; m.p. 89-91 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2,2-dimethoxypropanoate, its application will become more common.

Reference:
Patent; Boehringer Mannheim GmbH; US4425360; (1984); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10076-48-9, name is Methyl 2,2-dimethoxypropanoate, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H12O4

Then while still at 127 C., powdered potassium hydroxide (0.35 g, 0.006 mol) was added in one portion. There was an immediate exotherm to 135 C. In less than 40 minutes, conversion of methyl 2,2-dimethoxypropionate to methyl 2-methoxyacrylate was greater than 99%.

According to the analysis of related databases, 10076-48-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chevron Research Company; US4304928; (1981); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 10076-48-9, These common heterocyclic compound, 10076-48-9, name is Methyl 2,2-dimethoxypropanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 5 Methyl 2,2-dimethoxypropionate (66.9 g, 0.45 mol), hydroquinone (0.1 g), quinoline (74.5 g, 0.58 mol) (dried over potassium hydroxide), and acetyl chloride (48.4 g, 0.62 mol) were combined at 5-10 C. in a Fischer-Porter bottle. Powdered potassium hydroxide (0.45 g, 0.008 mol) was added. The reaction mix formed a thick white slurry. The bottle was sealed, stirred with a magnetic stirrer, and placed in a 122 C. oil bath. After three hours the bottle pressure was 19-22 psig. The reaction mixture was diluted with toluene and the quinoline hydrochloride was removed by filtration. The filtrate was concentrated and distilled to give methyl 2-methoxyacrylate (35 g, 68%): bp 35 C. (4 torr). This example demonstrates that methyl 2-methoxyacrylate can be prepared using superatmospheric pressure.

Statistics shows that Methyl 2,2-dimethoxypropanoate is playing an increasingly important role. we look forward to future research findings about 10076-48-9.

Reference:
Patent; Chevron Research Company; US4304928; (1981); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics