Category: 10047-10-6

Chinthaparthi, Radha Rani published the artcileSynthesis, characterisation and antimicrobial activity of 3-thio-1,5-dihydro-2,4,3-benzodioxaphosphepin-3-amino acid esters, Related Products of esters-buliding-blocks, the main research area is thioxohydrobenzodioxaphosphepinamino acid ester preparation antibacterial antifungal; thioxohydrobenzodioxaphosphepine amino ester preparation antibacterial antifungal.

A new series of 8-methoxy-3-thioxo-1,5-dihydro-2,4,3-benzodioxaphosphepin-3-amino acid esters was synthesized by treating various amino ester hydrochlorides with a P monochloride intermediate, which was generated in situ from 4-MeOC6H3-1,2-(CH2OH)2 and PSCl2 in the presence of Et3N in anhydrous THF at 0-5° to room temperature The title compounds exhibited significant antibacterial and antifungal activity.

Organic Communications published new progress about Amino acid esters Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 10047-10-6 belongs to class esters-buliding-blocks, name is Methyl 2-aminopentanoate hydrochloride, and the molecular formula is C6H14ClNO2, Related Products of esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yancheva, Denista published the artcileSynthesis, crystal structure and biological activity screening of novel N-(α-bromoacyl)-α-amino esters containing valyl moiety, SDS of cas: 10047-10-6, the main research area is bromoacyl amino ester valyl synthesis crystal structure drug screening; peptide coupling antiinflammatory antibacterial antitumor agent cytotoxicity.

Three novel N-(α-bromoacyl)-α-amino esters: Me 2-(2-bromo-3-methylbutanamido)pentanoate, Me 2-(2-bromo-3-methylbutanamido)-2-phenylacetate and Me 2-(2-bromo-3-methylbutanamido)-3-phenylpropanoate were synthesized. Single crystal X-ray diffraction data are reported for compounds Me 2-(2-bromo-3-methylbutanamido)pentanoate and Me 2-(2-bromo-3-methylbutanamido)-2-phenylacetate. The cytotoxicity, anti-inflammatory and antibacterial activity of compounds bromoacyl amino esters were investigated. Addnl., the physico-chem. properties of studied compounds were calculated and an in silico toxicol. study of compounds the amino esters was performed. The low level of cytotoxicity and absence of antibacterial and anti-inflammatory activity of N-(α-bromoacyl)-α-amino esters in tested concentrations might be a beneficial prerequisite for their incorporation in prodrugs.

Acta Chimica Slovenica published new progress about Anti-inflammatory agents. 10047-10-6 belongs to class esters-buliding-blocks, name is Methyl 2-aminopentanoate hydrochloride, and the molecular formula is C6H14ClNO2, SDS of cas: 10047-10-6.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Hui Ying published the artcileNovel phosphonoacetic acid derivatives. Synthesis of N-(ethoxycarbonylmethylphosphonyl)-α-amino acid esters and -α-amino phosphonic acid esters and their bioactivities, Application In Synthesis of 10047-10-6, the main research area is amino acid phosphonoacetate preparation virucide; phosphonate amino phosphonoacetate preparation virucide.

A series of novel phosphonoacetic acid derivatives, N-(ethoxycarbonylmethylethoxyphosphonyl)-α-amino acid esters and α-amino phosphonates, were synthesized via the reaction of the corresponding phosphonyl chloride with amino acid ester hydrochlorides or amino phosphonates in the presence of a base. The preliminary bioassay shows that some compounds show significant anti-viral activity against tobacco mosaic virus (TMV).

Chinese Chemical Letters published new progress about Antiviral agents. 10047-10-6 belongs to class esters-buliding-blocks, name is Methyl 2-aminopentanoate hydrochloride, and the molecular formula is C6H14ClNO2, Application In Synthesis of 10047-10-6.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 10047-10-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 10047-10-6 as follows.

Glacial AcOH (4.2 mL, 73.4 mmol) was added to a magnetically stirred solution of 2,5-dimethoxytetrahydrofuran (11.5 mL, 88.8 mmol) in H2O (200 mL) maintained under N2 and the ensuing mixture was heated at reflux. After 3 h, the mixture was cooled to r.t. and CH2Cl2 (200 mL), NaOAc (18.2g, 221 mmol) and DL-norvaline methyl ester hydrochloride (S8) (12.22 g, 72.9 mmol, as a ~40 mL solution in H2O) were added; the flask was wrapped in foil to exclude light. After 16 h, the pH of the aqueous phase was adjusted to ~9 with Na2CO3 (saturated aqueous solution). The phases were separated and the aqueous phase was further extracted with CH2Cl2 (3x 50 mL). The combined organic extracts were dried (MgSO4), filtered and concentrated under reduced pressure to a volume of ~25 mL. The ensuing solution was passed through plug of silica gel (7 cm width x 3 cm depth; 20% EtOAc/hexanes elution) to provide pyrrole S9 (12.4 g, 68.6 mmol, 94% yield) as a colourless oil.2

According to the analysis of related databases, 10047-10-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Olivier, Wesley J.; Gardiner, Michael G.; Bissember, Alex C.; Smith, Jason A.; Tetrahedron; vol. 74; 38; (2018); p. 5436 – 5441;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 10047-10-6, name is Methyl 2-aminopentanoate hydrochloride, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10047-10-6, category: esters-buliding-blocks

General procedure: To a solution of N-chlorosulfonyl isocyanate (11.32 g; 80 mmol) in dry methylene chloride (120 mL) cooled in an ice bath was added dropwise a solution of t-butyl alcohol (5.93 g; 80 mmol) in dry methylene chloride (120 mL). The resulting mixture was added dropwise to a mixture of glycine methyl ester hydrochloride (10.05 g; 80 mmol) and triethylamine (16.16 g; 160 mmol) in dry methylene chloride (120 mL) kept at 0 C. The ice bath was removed and the reaction mixture was allowed to stir at room temperature overnight. The resulting solution was washed sequentially with 5% aqueous HCl (3 ¡Á 100 mL) and brine (100 mL). The organic layer was separated, dried over anhydrous sodium sulfate, filtered, and the solvent was removed on the rotary evaporator, leaving compound 1a as a white solid (14.56 g; 68% yield), mp 98-100 C.

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Reference:
Article; Dou, Dengfeng; Tiew, Kok-Chuan; Mandadapu, Sivakoteswara Rao; Gunnam, Mallikarjuna Reddy; Alliston, Kevin R.; Kim, Yunjeong; Chang, Kyeong-Ok; Groutas, William C.; Bioorganic and Medicinal Chemistry; vol. 20; 6; (2012); p. 2111 – 2118;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10047-10-6, name is Methyl 2-aminopentanoate hydrochloride, A new synthetic method of this compound is introduced below., COA of Formula: C6H14ClNO2

(a) To a stirred solution of 7.36 ml (84.9 mmol) of chlorosulfonyl isocyanate in 150 ml of methylene chloride was added benzyl alcohol (8.82 ml, 84.7 mmol) at 0-5 C. After stirring the above solution for 1.5 hours at this temperature, a solution of 15.62 g (93.25 mmol) of 2-amino-pentanoic acid methyl ester hydrochloride in 500 ml of methylene chloride containing triethylamine (25.54 g, 0.2528 mol) was added at 0-5 C., and the resulting mixture was stirred overnight allowing the mixture to warm to room temperature. The reaction mixture was poured into 600 ml of 10% aq. HCl solution, saturated with sodium chloride, and the organic layer was separated. The aqueous layer was extracted with methylene chloride/ethyl acetate (4:1, 2*200 ml) and the combined organic layer was washed with brine, dried and concentrated in vacuo to yield 28.2 g (87.6%) of 2-(N-carbobenzyloxyaminosulfonyl) aminopentanoic acid methyl ester (Formula XIV: R=CH3, R1 =H; R2 =propyl; R3 =H) as a solid, m.p. 76-78 C.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Sterling Winthrop Inc.; US5494925; (1996); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A common compound: 10047-10-6, name is Methyl 2-aminopentanoate hydrochloride, belongs to esters-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 10047-10-6

EXAMPLE 11 Synthesis of METHYL N-F (4 -IODOBIPHENYL-4-YL) CARBONYLL-L-LEUCYLNORVALINATE Methyl N [ (4′-iodobiphenyl-4-yl) carbonyl]-L-leucinate (22.5 g, 50 mmoles) in 100 mL of tetrahydrofuran, 40 ML of methanol and 10 mL of water is treated with a suspension of lithium hydroxide monohydrate (3.15 g, 75 mmoles) in 20 mL of boiling water. The reaction was stirred until completion as judged by TLC. Reaction was carefully adjusted to pH 4 approximately by addition of 1 N HCl and most of the solvents were removed under reduced pressure. The concentrated suspension was diluted with dichloromethane (200 ML) and 1 N HCl (150 ML). The phases were separated and the aqueous phase was washed with dichloromethane (150 mL). The combined organic layers were dried over magnesium sulfate and concentrated under reduced pressure. The residue was dissolved in DIMETHYLFORMAMIDE (100 mL) and treated with racemic norvaline hydrochloride (8.6 g, 51 moles) followed by HATU (19.6 g, 51 mmoles). After one minute, triethylamine (17.5 mL, 125 mmoles) was added and the reaction stirred overnight. The reaction medium was diluted with ethyl acetate (300 ML), diethyl ether (100 ML) and IN hydrochloric acid (300 ML). The phases were separated and the organic phase was washed with 0.1 N hydrochloric acid (200 mL), two 200-ML portions of water and brine (100 ML). The organic phase was dried over magnesium sulfate and concentrated under reduced pressure to obtain a solid which was purified by trituration in ether.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 10047-10-6, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK FROSST CANADA & CO.; WO2005/28424; (2005); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics