《Process improvement on the synthesis of 1-benzyloxycarbonyl-3-(t-butoxycarbonylamino)azetidine》 was written by Wang, Xian-xun; Zhou, Guo-chuan. Product Details of 1000577-78-5 And the article was included in Hecheng Huaxue on April 30 ,2009. The article conveys some information:
1-Benzyloxycarbonyl-3-(t-butoxycarbonylamino)azetidine in total yield of 22.9% was synthesized by the reaction of ring-opening, cyclization, substitution, reduction and debenzylation from benzylamine and epichlorohydrin. The structure was determined by 1H NMR, 13C NMR and MS. After reading the article, we found that the author used tert-Butyl (1-benzylazetidin-3-yl)carbamate(cas: 1000577-78-5Product Details of 1000577-78-5)
tert-Butyl (1-benzylazetidin-3-yl)carbamate(cas:1000577-78-5) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Product Details of 1000577-78-5 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics