Author: Jessica.F

A Mild and Efficient Direct α-Amination of β-Dicarbonyl Compounds Using Iodosobenzene and p-Toluenesulfonamide Catalyzed by Perchlorate Zinc Hexahydrate was written by Yu, Jun;Liu, Shan-Shan;Cui, Jian;Hou, Xue-Sen;Zhang, Chi. And the article was included in Organic Letters in 2012.COA of Formula: C9H10O3S This article mentions the following:

A direct α-amination of β-dicarbonyl compounds has been achieved by using iodosobenzene (PhIO) as an oxidant and p-toluenesulfonamide (TsNH₂) as an aminating reagent in the presence of a catalytic amount of perchlorate zinc hexahydrate. The present amination reaction proceeds quickly at rt (<30 min needed for most tested substrates) to provide the corresponding α-N-tosylamido β-dicarbonyl compounds in high to excellent yields. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8COA of Formula: C9H10O3S).

Ethyl 3-oxo-3-(thiophen-2-yl)propanoate (cas: 13669-10-8) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.COA of Formula: C9H10O3S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Discovery of PF-04449913, a Potent and Orally Bioavailable Inhibitor of Smoothened was written by Munchhof, Michael J.;Li, Qifang;Shavnya, Andrei;Borzillo, Gary V.;Boyden, Tracey L.;Jones, Christopher S.;LaGreca, Susan D.;Martinez-Alsina, Luis;Patel, Nandini;Pelletier, Kathleen;Reiter, Larry A.;Robbins, Michael D.;Tkalcevic, George T.. And the article was included in ACS Medicinal Chemistry Letters in 2012.Recommanded Product: 16413-26-6 This article mentions the following:

Inhibitors of the Hedgehog signaling pathway have generated a great deal of interest in the oncol. area due to the mounting evidence of their potential to provide promising therapeutic options for patients. Herein, we describe the discovery strategy to overcome the issues inherent in lead structure 1 that resulted in the identification of Smoothened inhibitor 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea (PF-04449913, 26), which has been advanced to human clin. studies. In the experiment, the researchers used many compounds, for example, 3-Cyanophenylisocyanate (cas: 16413-26-6Recommanded Product: 16413-26-6).

3-Cyanophenylisocyanate (cas: 16413-26-6) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 16413-26-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Aqueous CO₂ fixation: construction of pyridine skeletons in cooperation with ammonium cations was written by Xiang, Shiqun;Fan, Weibin;Zhang, Wei;Li, Yinghua;Guo, Shiwei;Huang, Deguang. And the article was included in Green Chemistry in 2021.Application of 33166-79-9 This article mentions the following:

A simple and green method is explored for the synthesis of fused pyridines e.g., 3,7-dimethyl-10,12-dihydrodiindeno[1,2-b:2′,1′-e]pyridine by [2 + 2 + 1 + 1] the cycloaddition of ketones e.g., 6-methyl-1-indanone with an ammonium cation under a CO₂ atmosphere. The reactions employed ammonium cation as a nitrogen source and CO₂ gas as a carbon source in an aqueous solution Monoethanolamine (MEA) was used as an additive to increase the solubility of CO₂ in an aqueous solution The scope and versatility of the method are demonstrated with examples e.g., 3,7-dimethyl-10,12-dihydrodiindeno[1,2-b:2′,1′-e]pyridine. Products are found to be photosensitive and show potential applications as organic optoelectronic materials. A selectfluor-promoted reaction mechanism is proposed based on the exptl. studies. This work is superior as it is a metal-free system, uses CO₂ as a carbon source and MEA as an additive in aqueous synthesis. In the experiment, the researchers used many compounds, for example, Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9Application of 33166-79-9).

Ethyl 3-oxo-3-(m-tolyl)propanoate (cas: 33166-79-9) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application of 33166-79-9

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis and antibacterial activity of emodin and its derivatives against methicillin-resistant Staphylococcus aureus was written by Chalothorn, Thidarat;Rukachaisirikul, Vatcharin;Phongpaichit, Souwalak;Pannara, Sakawrat;Tansakul, Chittreeya. And the article was included in Tetrahedron Letters in 2019.Application In Synthesis of Methyl 2-methoxy-4-methylbenzoate This article mentions the following:

Synthesis of the antibacterial emodin (I) was improved using Friedel-Crafts acylation as a key step leading to 37% overall yield. In addition, 21 analogs were synthesized by structural modification of the hydroxyl and Me groups, as well as the aromatic ring of emodin. Antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and cytotoxicity against noncancerous Vero cells were evaluated. A structure-activity relationship (SAR) study indicated that the hydroxyl groups and the Me group in the emodin skeleton were crucial for anti-MRSA activity. Furthermore, the presence of an iodine atom or ethylamino group on the aromatic ring enhanced the anti-MRSA activity with higher selectivity indexes, while derivatives containing bromine, chlorine atoms or quaternary ammonium salt were as active as emodin. The quaternary ammonium group on the aromatic ring also led to non-cytotoxicity against Vero cells. In the experiment, the researchers used many compounds, for example, Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1Application In Synthesis of Methyl 2-methoxy-4-methylbenzoate).

Methyl 2-methoxy-4-methylbenzoate (cas: 81245-24-1) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Application In Synthesis of Methyl 2-methoxy-4-methylbenzoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Aroma profiles of green tea made with fresh tea leaves plucked in summer was written by Guo, Xiangyang;Ho, Chi-Tang;Schwab, Wilfried;Wan, Xiaochun. And the article was included in Food Chemistry in 2021.COA of Formula: C12H22O4 This article mentions the following:

There is a claim that fresh tea leaves plucked in summer (FTL-S) are not suitable for green tea processing, but there is no scientific evidence to support this claim. The aroma properties of green tea (GT-S) made with FTL-S were studied by the anal. of volatiles during process, coupled with odor activity value (OAV) determination The odor profiles of dry tea and tea infusion were investigated by sensory evaluation. The GT-S contained higher proportions of alcs., alkenes and heterocyclic compounds with strong fragrance and nutty odors as well as moderate floral odor in comparison with FTL-S. β-Damascenone and 2-ethyl-3,5-dimethylpyrazine with the OAV of 54,290 and 1.15, resp., were the aroma-active compounds imparting woody and nutty odors in GT-S, resp. Current study provides an alternative way to use FTL-S for green tea production, and we also found that L-theanine is an important aroma precursor for the formation of green tea aroma. In the experiment, the researchers used many compounds, for example, Dimethyl decanedioate (cas: 106-79-6COA of Formula: C12H22O4).

Dimethyl decanedioate (cas: 106-79-6) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. COA of Formula: C12H22O4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Controlled radical polymerization of N-vinylpyrrolidone and N-vinylsuccinimide under the conditions of reversible chain transfer by the addition-fragmentation mechanism was written by Chernikova, E. V.;Terpugova, P. S.;Filippov, A. N.;Garina, E. S.;Golubev, V. B.;Gostev, A. I.;Sivtsov, E. V.. And the article was included in Russian Journal of Applied Chemistry in 2009.Synthetic Route of C14H12S2 This article mentions the following:

Regular trends in controlled radical polymerization of N-vinylpyrrolidone and N-vinylsuccinimide by the mechanism of reversible chain transfer in the presence of a series of dithiobenzoates and trithiocarbonates were studied. The possibility of preparing soluble poly-N-vinylsuccinimide in concentrated solutions using benzyl benzodithioate as reversible chain-transfer agent was demonstrated. In the experiment, the researchers used many compounds, for example, Benzyl benzodithioate (cas: 27249-90-7Synthetic Route of C14H12S2).

Benzyl benzodithioate (cas: 27249-90-7) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Synthetic Route of C14H12S2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

5-Unsubstituted 2-pyrrolecarboxaldehydes for porphyrin synthesis and the cyanovinyl protecting group was written by Paine, John B. III;Dolphin, David. And the article was included in Journal of Organic Chemistry in 1988.Recommanded Product: 2199-49-7 This article mentions the following:

(Cyanovinyl)pyrroles I (R = Me, R¹ = Et, octyl; R = Et, R¹ = Me) derived from the Knoevenagel condensation of benzyl 5-formyl-2-pyrrolecarboxylates with NCCH₂CO₂Me were employed in a facile sequence of 4 steps to produce, regioselectively, 2-pyrrolecarboxaldehydes II, important intermediates for porphyrin synthesis. Each step proceeded in 90-95% yield, making II available smoothly from benzyl 5-methyl-2-pyrrolecarboxylates in 7 steps, with an overall yield of 66-72%. In the experiment, the researchers used many compounds, for example, Ethyl 4-methyl-1H-pyrrole-3-carboxylate (cas: 2199-49-7Recommanded Product: 2199-49-7).

Ethyl 4-methyl-1H-pyrrole-3-carboxylate (cas: 2199-49-7) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 2199-49-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Diversity in principal constituents of plants with a lemony scent and the predominance of citral was written by Hirai, Miho;Ota, Yue;Ito, Michiho. And the article was included in Journal of Natural Medicines in 2022.SDS of cas: 105-87-3 This article mentions the following:

In this study, we extracted essential oils from four species of plants with lemony scents (Melissa officinalis L., Aloysia citriodora Palau (= Lippia citriodora (Palau) Kunth), Thymus x citriodorus, Perilla citriodora (Makino) Nakai). We then examined the components of extracts using gas chromatog. (GC) and GC-mass spectrometry (GC-MS). A comparison of components indicated that the largest proportions of essential oils were caryophyllene (25%) in M. officinalis, geraniol (50%) in T. citriodorus, and citral (61 and 82%) in A. citriodora and P. citriodora. Moreover, we used a sensory evaluation method using dilute aqueous solutions of extract components, citral, linalool, d-limonene, and geraniol, to select the mixture with a flavor that mostly resembled lemon. The participants in the study felt that an aqueous citral solution flavored more like lemon than aqueous d-limonene. Furthermore, an open field study of sedative effects of citral and d-limonene, when inhaled, on mice demonstrated that citral exhibited a sedative effect at a lower concentration than that of d-limonene. In the experiment, the researchers used many compounds, for example, (E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3SDS of cas: 105-87-3).

(E)-3,7-Dimethylocta-2,6-dien-1-yl acetate (cas: 105-87-3) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.SDS of cas: 105-87-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Palladium-Catalyzed Carbonylative Direct Transformation of Benzyl Amines under Additive-Free Conditions was written by Li, Yahui;Wang, Zechao;Wu, Xiao-Feng. And the article was included in ACS Catalysis in 2018.Electric Literature of C7H8O2S This article mentions the following:

In this communication, authors developed a new procedure for the direct carbonylative transformation of benzyl amines. Using di-Me carbonate as the solvent, Me 2-arylacetates can be produced in good to excellent yields from the corresponding primary, secondary, and tertiary benzyl amines with palladium as the catalyst. Notably, no base or any other additive is required here. In addition, the procedure can also be applied in the preparation of methylphenidate, which is a marketing drug and used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. In the experiment, the researchers used many compounds, for example, Methyl 2-thienylacetate (cas: 19432-68-9Electric Literature of C7H8O2S).

Methyl 2-thienylacetate (cas: 19432-68-9) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Electric Literature of C7H8O2S

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

A comparative study of volatile flavor components in four types of zaoyu using comprehensive two-dimensional gas chromatography in combination with time-of-flight mass spectrometry was written by Chen, Zhipeng;Tang, Haiqing;Ou, Changrong;Xie, Cheng;Cao, Jinxuan;Zhang, Xin. And the article was included in Journal of Food Processing and Preservation in 2021.Product Details of 695-06-7 This article mentions the following:

Volatiles of four zaoyu (Chinese traditional fermented fish) products prepared from different species of marine fish were analyzed by headspace solid-phase micro-extraction (HS-SPME) and comprehensive two-dimensional gas chromatog. in combination with time-of-flight mass spectrometry (GC × GC/TOFMS). First, a 50/30Μ m DVB/CAR/PDMS was used and the influence of several parameters on the efficiency of HS-SPME such as extraction temperature, time, salting-out effect, and stirring were optimized, odor activity values (OAVs) of volatile compounds were computed based on the threshold values of aroma constituents; the characteristic volatiles and their odor characteristics of the four zaoyu were investigated. The results demonstrated that the most effective extraction of the analytes was obtained with a 40 min extraction at 50°C with the addition of 20% NaCl and stirring at 300 r/min. Under these conditions, a total of 288 volatile components were tentatively identified based on mass spectra and comparison of linear retention indexes in the four zaoyu products. Authenticated compounds included aldehydes, esters, alcs., ketones, furans, lactones, nitrogen compounds, sulfur compounds, terpenes, phenols, etc. Among the identified types of volatile compounds, the number of esters is the largest, whereas the content of aldehydes is the highest. The results of OAVs comparisons proved that both aldehydes and esters provided the most significant contribution to the aromas of zaoyu, and each zaoyu product had its own unique active flavor components. Moreover, the OAVs of active flavor compounds common to the four examined zaoyu varied significantly. Our results substantiated that GC × GC/TOFMS could provide a robust tech. means to understand the flavor characteristics of zaoyu and allow us to better evaluate and improve the flavor quality of the products with complex food matrix like zaoyu. The method present in this research is suitable to characterize the volatile constituents of aquatic products, and could also be used for component characterization of similar complex samples such as fermented fish and foods. Understanding the key aroma compounds of fermented fish and its formation mechanism could provide a guide of process optimization and flavor regulation, contributing to further studies related to volatile compounds in the field of food flavor anal. In the experiment, the researchers used many compounds, for example, 5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7Product Details of 695-06-7).

5-Ethyldihydrofuran-2(3H)-one (cas: 695-06-7) belongs to esters. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Product Details of 695-06-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics