Marsault, Eric; Hoveyda, Hamid R.; Peterson, Mark L.; Saint-Louis, Carl; Landry, Annick; Vezina, Martin; Ouellet, Luc; Wang, Zhigang; Ramaseshan, Mahesh; Beaubien, Sylvie; Benakli, Kamel; Beauchemin, Sophie; Deziel, Robert; Peeters, Theo; Fraser, Graeme L. published the artcile< Discovery of a New Class of Macrocyclic Antagonists to the Human Motilin Receptor>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is macrocyclic peptidomimetic preparation antagonist SAR human motilin receptor.
A novel class of macrocyclic peptidomimetics was identified and optimized as potent antagonists to the human motilin receptor (hMOT-R). Well-defined structure-activity relationships allowed for rapid optimization of potency that eventually led to high affinity antagonists to hMOT-R. Potency and antagonist functional activity were confirmed both in functional and cell-based assays, as well as on isolated rabbit intestinal smooth muscle strips. Rapid access to this novel class of macrocyclic target structures was made possible through two efficient and complementary solid-phase parallel synthetic approaches, both of which are reported herein.
Journal of Medicinal Chemistry published new progress about Amino acids Role: RCT (Reactant), RACT (Reactant or Reagent). 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics