Diaz-Sanchez, Blanca R.; Iglesias-Arteaga, Martin A.; Melgar-Fernandez, Roberto; Juaristi, Eusebio published the artcile< Synthesis of 2-Substituted-5-halo-2,3-dihydro-4(H)-pyrimidin-4-ones and Their Derivatization Utilizing the Sonogashira Coupling Reaction in the Enantioselective Synthesis of α-Substituted β-Amino Acids>, Formula: C19H34O2, the main research area is pyrimidinone dihydro derivative preparation enantioselective conversion beta amino acid; crystal structure dihydropyrimidinone; mol structure dihydropyrimidinone.
A convenient, one-pot procedure for the synthesis of 1-benzoyl-2(S)-substituted-5-iodo-2,3-dihydropyrimidin-4(1H)-ones by tandem decarboxylation/β-iodination of the corresponding 6-carboxy-perhydropyrimidin-4-ones was developed. Several 1-benzoyl-2(S)-substituted-5-bromo-2,3-dihydropyrimidin-4(1H)-ones were readily prepared by bromination of 1-benzoyl-2(S)-substituted-2,3-dihydropyrimidin-4(1H)-ones. Subsequently, Sonogashira coupling of the halogenated heterocyclic enones with various terminal alkynes produced 1-benzoyl-2(S)-isopropyl-5-alkynyl-2,3-dihydropyrimidin-4(1H)-ones in good yields. Hydrogenation of the unsaturated C-C moieties in a Sonogashira product followed by acid hydrolysis afforded a highly enantioenriched α-substituted β-amino acid (S)-2-(aminomethyl)-4-phenylbutanoic acid. The crystal and mol. structures of 1-benzoyl-2(S)-phenyl-2,3-dihydropyrimidin-4(1H)-one, 1-benzoyl-2(S)-isopropyl-5-bromo-2,3-dihydropyrimidin-4(1H)-one, 1-benzoyl-2(S)-isopropyl-5-phenylethynyl-2,3-dihydropyrimidin-4(1H)-one were determined by x-ray crystallog.
Journal of Organic Chemistry published new progress about Crystal structure. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Formula: C19H34O2.
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics