Reference of 41841-16-1,Some common heterocyclic compound, 41841-16-1, name is Methyl 2-(4-bromophenyl)acetate, molecular formula is C9H9BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Methyl 2-(4-bromophenyl)acetate (1.00 g, 4.37 mmol)Dissolved in anhydrous DMF (12.5mL),The reaction solution is under N2 protection,Add NaH (700 mg, 17.5 mmol, 60%) at 0 C.Stir for about 15 minutes,CH3I (1.62 mL) was added slowly.After the dropwise addition was completed, the reaction solution was further stirred at 0 C for 15 minutes.Then transfer to room temperature for 12 h.After the reaction with saturated ammonium chloride (20mL) The reaction was quenched and extracted with EA (20mL), the organic layer was washed with saturated brine (30 mL), thenAfter concentration under reduced pressure,To give the title compound as a yellow oily substance (1.12g, 99.8%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-(4-bromophenyl)acetate, its application will become more common.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Liu Xinchang; Ren Qingyun; Yan Guanghua; S ¡¤geerdeman; Zhang Yingjun; (200 pag.)CN109678859; (2019); A;,
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