Synthetic Route of 35613-44-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35613-44-6, name is Methyl 2-(2-aminophenyl)acetate, This compound has unique chemical properties. The synthetic route is as follows.
A mixture of 7.2 g of 4-chloro-7-trifluoromethylquinoline, 5.4 g of methyl 2- aminophenylacetate and 250 mL of acetonitrile is heated under reflux for 18 hours. The solvent is evaporated under reduced pressure and the residue extracted 3 times with 200 mL portions of hot water. The aqueous extract is rendered basic with 10% ammonium hydroxide whereupon the desired compound precipitated; it was recrystallized from aqueous ethanol yielding colorless needles with a melting point of 140-1410C.
The chemical industry reduces the impact on the environment during synthesis Methyl 2-(2-aminophenyl)acetate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; MILESTONE PHARMACEUTICALS INC.; WO2008/48577; (2008); A1;,
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