Aguilar-Morante, Diana; Gomez-Cabello, Daniel; Quek, Hazel; Liu, Tianqing; Hamerlik, Petra; Lim, Yi Chieh published the artcile< Therapeutic Opportunities of Disrupting Genome Integrity in Adult Diffuse Glioma>, Product Details of C19H34O2, the main research area is review glioma glioblastoma genome central nervous system therapeutics; CNS tumors; DNA damage response; DNA repair; glioma; molecular markers; pharmacotherapeutics; precision medicine; synthetic lethality; targeted therapy.
A review. Adult diffuse glioma, particularly glioblastoma (GBM), is a devastating tumor of the central nervous system. The existential threat of this disease requires on-going treatment to counteract tumor progression. The present outcome is discouraging as most patients will succumb to this disease. The low cure rate is consistent with the failure of first-line therapy, radiation and temozolomide (TMZ). Even with their therapeutic mechanism of action to incur lethal DNA lesions, tumor growth remains undeterred. Delivering addnl. treatments only delays the inescapable development of therapeutic tolerance and disease recurrence. The urgency of establishing lifelong tumor control needs to be re-examined with a greater focus on eliminating resistance. Early genomic and transcriptome studies suggest each tumor subtype possesses a unique mol. network to safeguard genome integrity. Subsequent seminal work on post-therapy tumor progression sheds light on the involvement of DNA repair as the causative contributor for hypermutation and therapeutic failure. In this review, we will provide an overview of known mol. factors that influence the engagement of different DNA repair pathways, including targetable vulnerabilities, which can be exploited for clin. benefit with the use of specific inhibitors.
Biomedicines published new progress about Central nervous system. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Product Details of C19H34O2.
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