Liu, Junnan; Zhao, Min; Zhang, Shuang; Liu, Jiaonan; Zhao, Chunjie; Wang, Miao published the artcile< Rapid characterization of the chemical constituents of Wangbi Capsule by UPLC coupled with Fourier transform ion cyclotron resonance mass spectrometry>, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate, the main research area is capsule UPLC ion cyclotron resonance mass spectrometry.
Wangbi Capsule is a compound preparation composed of 17 traditional Chinese medicines, which is widely used in the treatment of rheumatoid arthritis. In our study, a rapid and straightforward anal. method was successfully established by using Ultra performance liquid chromatog. coupled with Fourier transform ion cyclotron resonance mass spectrometry technol. to quickly sep. and identify the chem. constituents of Wangbi Capsule. The chromatog. was performed on a Universal XB-C18 column (2.1 mm x 150 mm, 3μm) by the mobile phase containing acetonitrile (A)-0.1% formic acid and water (B) at the flow rate of 0.2 mL/min. The pos. and neg. ions of the samples were analyzed by extraction ion chromatog. Based on accurate mass spectrometry informations such as excimer ions and fragment ions, combined with the reference materials and the reference literature, 140 compounds in the Wangbi Capsule were identified or preliminarily characterized. The results of the study show that Wangbi Capsules mainly contain 3 types of nucleosides, 31 types of alkaloids, 12 types of organic acids, 29 types of flavonoids, 12 types of monoterpene glycosides, 30 types of coumarins, 10 types of chromones, 3 types of saponins, 6 kinds of phenylethanoid glycosides and other chem. components. The method established in this study can quickly and efficiently identify the chem. constituents in Wangbi Capsules. It is hoped that it will have a certain significance for the characterization of other Chinese medicine components and lay the foundation for pharmacol. research and subsequent in vivo studies of Wangbi Capsules.
Microchemical Journal published new progress about Capsules. 112-63-0 belongs to class esters-buliding-blocks, and the molecular formula is C19H34O2, Name: (9Z,12Z)-Methyl octadeca-9,12-dienoate.
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