Formula: C15H28O2《Iridium-Catalyzed Reductive Allylation of Esters》 was published in 2019. The authors were Xie, Lan-Gui;Rogers, Jack;Anastasiou, Ioannis;Leitch, Jamie A.;Dixon, Darren J., and the article was included in《Organic Letters》. The author mentioned the following in the article:
The catalytic reductive transformation of carboxylic esters into α-branched ethers is described. The procedure pivots on the chemoselective iridium-catalyzed hydrosilylation of ester and lactone functionality to afford a silyl acetal intermediate. Upon treatment with a Lewis acid, these hemilabile intermediates dissociate to form reactive oxocarbenium ions, which can be intercepted by allyltributyltin nucleophiles, resulting in the formation of valuable α-branched alkyl-alkyl ether derivatives This reductive allylation procedure was found to be amenable to a range of carboxylic ester starting materials, and good chemoselectivity for Et over tert-Bu esters was demonstrated. Furthermore, downstream synthetic manipulation of α-amino acid-derived products led to the efficient formation of pyrrolidine, piperidine, and azepane frameworks. And Oxacyclohexadecan-2-one (cas: 106-02-5) was used in the research process.
Oxacyclohexadecan-2-one(cas:106-02-5) is a natural product found in Lonicera japonica and Angelica archangelica.Formula: C15H28O2 It is a macrocyclic lactone that can be used as a flavoring agent and fragrance ingredient due to its musk flavor/odor.
Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics