Long, Jiao;Gao, Wenchao;Guan, Yuqing;Lv, Hui;Zhang, Xumu published 《Nickel-Catalyzed Highly Enantioselective Hydrogenation of β-Acetylamino Vinylsulfones: Access to Chiral β-Amido Sulfones》 in 2018. The article was appeared in 《Organic Letters》. They have made some progress in their research.Electric Literature of C9H10O2 The article mentions the following:
In the presence of Ni(OAc)2 and (S)-Binapine in 1:9 MeOH/F3CCH2OH (TFE), β-(acetylamino)-α,β-unsaturated sulfones (Z)-RC(NHCOMe):CHSO2R1 (R = Ph, 4-MeC6H4, 3-MeC6H4, 4-t-BuC6H4, 4-MeOC6H4, 4-ClC6H4, 3-ClC6H4, 4-BrC6H4, 4-FC6H4, 3-FC6H4, 4-F3CC6H4, 2-thienyl, cyclohexyl, Et; R1 = Me, Ph) underwent enantioselective hydrogenation to give β-(acetylamino) sulfones (S)-RCH(NHCOMe)CH2SO2R1 (R = Ph, 4-MeC6H4, 3-MeC6H4, 4-t-BuC6H4, 4-MeOC6H4, 4-ClC6H4, 3-ClC6H4, 4-BrC6H4, 4-FC6H4, 3-FC6H4, 4-F3CC6H4, 2-thienyl, cyclohexyl, Et; R1 = Me, Ph) in 75-95% yields and in 90->99% ee. The 1:1 (E):(Z) mixture of PhC(NHCOMe):CHSO2Ph underwent enantioselective hydrogenation to give (S)-PhCH(NHCOMe)CH2SO2Ph in 85% yield and 97% ee; in a sep. hydrogenation reaction performed on gram scale, 0.2 mol% of the nickel catalyst was used.Methyl 3-methylbenzoate (cas: 99-36-5) were involved in the experimental procedure.
Methyl 3-methylbenzoate (cas: 99-36-5) is a common ester.Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids.Electric Literature of C9H10O2 Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries.
Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics