Cas: 99-36-5 | Wu, Han et al. made new progress in 2020

Methyl 3-methylbenzoate (cas: 99-36-5) is a common ester.Esters are common in organic chemistry and biological materials, and often have a pleasant characteristic, fruity odor. This leads to their extensive use in the fragrance and flavor industry. Ester bonds are also found in many polymers.SDS of cas: 99-36-5

Wu, Han;Sun, Yu;Wong, Wee Lin;Cui, Jiajia;Li, Jingyang;You, Xuefu;Yap, Lee Fah;Huang, Yu;Hong, Wei;Yang, Xinyi;Paterson, Ian C.;Wang, Hao published 《The development of a novel transforming growth factor-β (TGF-β) inhibitor that disrupts ligand-receptor interactions》 in 2020. The article was appeared in 《European Journal of Medicinal Chemistry》. They have made some progress in their research.SDS of cas: 99-36-5 The article mentions the following:

Transforming growth factor-β (TGF-β) plays an important role in regulating epithelial to mesenchymal transition (EMT) and the TGF-β signaling pathway is a potential target for therapeutic intervention in the development of many diseases, such as fibrosis and cancer. Most currently available inhibitors of TGF-β signaling function as TGF-β receptor I (TβR-I) kinase inhibitors, however, such kinase inhibitors often lack specificity. In the present study, we targeted the extracellular protein binding domain of the TGF-β receptor II (TβR-II) to interfere with the protein-protein interactions (PPIs) between TGF-β and its receptors. One compound, CJJ300, inhibited TGF-β signaling by disrupting the formation of the TGF-β-TβR-I-TβR-II signaling complex. Treatment of A549 cells with CJJ300 resulted in the inhibition of downstream signaling events such as the phosphorylation of key factors along the TGF-β pathway and the induction of EMT markers. Concomitant with these effects, CJJ300 significantly inhibited cell migration. The present study describes for the first time a designed mol. that can regulate TGF-β-induced signaling and EMT by interfering with the PPIs required for the formation of the TGF-β signaling complex. Therefore, CJJ300 can be an important lead compound with which to study TGF-β signaling and to design more potent TGF-β signaling antagonists. And Methyl 3-methylbenzoate (cas: 99-36-5) was used in the research process.

Methyl 3-methylbenzoate (cas: 99-36-5) is a common ester.Esters are common in organic chemistry and biological materials, and often have a pleasant characteristic, fruity odor. This leads to their extensive use in the fragrance and flavor industry. Ester bonds are also found in many polymers.SDS of cas: 99-36-5

Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics