Slavchev, Ivaylo;Ward, Jas. S.;Rissanen, Kari;Dobrikov, Georgi M.;Simeonov, Svilen published 《Base-promoted direct amidation of esters: beyond the current scope and practical applications》. The research results were published in《RSC Advances》 in 2022.Reference of Methyl 3-methylbenzoate The article conveys some information:
The base-promoted direct amidation of unactivated esters is among the most useful reactions for amide bond formation in contemporary organic chem. The intensive research in this area has led to the development of a number of new methods to achive this transformation. However, to date, the existing literature is more methodol. and in many instances lacks practical directions. Therefore, the full potential of this transformation is yet to be revealed by broadening the substrate scope. In a search for new practical applications of the amidation reaction, herein a comprehensive study of a number of base-promoted direct amidations that encompass a wide range of amines and esters is presented. Furthermore, authors applied their findings in the synthesis of phosphoramidates and several industrially relevant products. The experimental procedure involved many compounds, such as Methyl 3-methylbenzoate (cas: 99-36-5) .
Methyl 3-methylbenzoate (cas: 99-36-5) is a common ester.Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids.Reference of Methyl 3-methylbenzoate Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries.
Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics