Adding a certain compound to certain chemical reactions, such as: 56741-34-5, name is Methyl 5-amino-2-fluorobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 56741-34-5, Quality Control of Methyl 5-amino-2-fluorobenzoate
Step C : Methyl 5-amino-2-fluorobenzoate (5.21g, 30. 8MMOL) was added to a solution of concentrated sulfuric acid (45mL) in water (110ML). The resulting mixture was heated at 80C for 20min then cooled to 0C and treated dropwise with a solution of NaNO2 (2.34g, 33. 9MMOL) in lOmL of water. After stirring for 30MIN, a solution OF KI (7.16g, 43. 1MMOL) in 20mL of water was added. The reaction mixture was then warmed to rt and stirred overnight under a nitrogen atmosphere. Then the reaction mixture was stirred at 70C for 15MIN, cooled to rt, and extracted twice with ether. The combined ethereal layers were washed four times with water, once with brine, dried over anhydrous MgSO4, filtered, and concentrated. Purification by flash chromatography (silica, 10% ethyl ACETATE/HEXANES) provided methyl 2-FLUORO-5-IODOBENZOATE. LH NMR (500 MHz, CDC13) 8 8.25 (dd, 1H), 7.82 (M, 1H), 6.94 (dd, IH), 3.95 (s, 3H). ESI-MS calc. for C8H6FI02 : 280; Found: 281 (M+H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 5-amino-2-fluorobenzoate, and friends who are interested can also refer to it.
Reference:
Patent; MERCK & CO., INC.; WO2004/92124; (2004); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics