Application In Synthesis of (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine, is researched, Molecular C36H30NO2P, CAS is 415918-91-1, about Mechanistic identification and improvement of a direct enantioconvergent transformation in copper-catalyzed asymmetric allylic alkylation. Author is Langlois, Jean-Baptiste; Emery, Daniel; Mareda, Jiri; Alexakis, Alexandre.
Recently, our group reported on the development of an unprecedented process in copper-catalyzed asym. allylic alkylation. This method allowed for the quant. transformation of a racemic substrate into an enantioenriched product. While a high level of asym. induction (up to 99% ee) was observed, the mechanistic understanding of the reaction remained fuzzy. In the present article, a thorough mechanistic anal., based on computational investigations, led to the identification of the reaction pathway. Notably, it uncovered that both enantiomers of the starting material converged independently to the same product via two different mechanistic routes. This specific feature established this process as a rare example of Direct Enantioconvergent Transformation. Finally, the modeling results prompted a valuable improvement of the reaction, relying on the use of a more accessible range of substrates.
Different reactions of this compound((11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine)Application In Synthesis of (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine require different conditions, so the reaction conditions are very important.
Reference:
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