Safety of 6-Bromo-8-methylquinoline. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 6-Bromo-8-methylquinoline, is researched, Molecular C10H8BrN, CAS is 178396-31-1, about Ru(II)-Catalyzed Chemoselective C(sp3)-H Monoarylation of 8-Methyl Quinolines with Arylboronic Acids. Author is Parmar, Diksha; Kumar, Rohit; Kumar, Rakesh; Sharma, Upendra.
The first [Cl2Ru(p-cymene)]2-catalyzed direct mono-arylation of unactivated C(sp3)-H bond of 8-Me quinolines with aryl boronic acids to synthesize 8-benzyl quinolines I [R = 2-Me, 7-Br, 5-NO2, etc.; R1 = 2-FC6H4, 4-ClC6H4, 4-MeOC6H4, etc.] was presented. The transformation showed broad substrate substrate scope with high chemoselectivity for the synthesis of 8-benzyl quinolines. In preliminary mechanistic study- control experiments, deuterium labeling experiments and kinetic studies had been performed.
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