The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: (11bR)-N,N-Bis[(1R)-1-phenylethyl]dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-amine(SMILESS: C[C@@H](N(P1OC2=CC=C3C=CC=CC3=C2C4=C5C=CC=CC5=CC=C4O1)[C@@H](C6=CC=CC=C6)C)C7=CC=CC=C7,cas:415918-91-1) is researched.Application In Synthesis of 2,5-Diphenyloxazole. The article 《Tandem Iridium Catalysis as a General Strategy for Atroposelective Construction of Axially Chiral Styrenes》 in relation to this compound, is published in Journal of the American Chemical Society. Let’s take a look at the latest research on this compound (cas:415918-91-1).
The first tandem iridium catalysis as a general strategy for the synthesis of axially chiral styrenes enabled by Asym. Allylic Substitution-Isomerization (AASI) using cinnamyl carbonate analogs as electrophiles and naphthols as nucleophiles. Axially chiral styrenes were generated through two independent iridium-catalytic cycles: iridium-catalyzed asym. allylic substitution and in-situ isomerization via stereospecific 1,3-hydride transfer catalyzed by the same iridium catalyst. Both exptl. and computational studies demonstrated that the isomerization proceeded by iridium-catalyzed benzylic C-H bond oxidative addition, followed by terminal C-H reductive elimination. Amid the central-to-axial chirality transfer, the hydroxyl of naphthol played a crucial role in ensured the stereospecificity by coordinating with the Ir(I) center. The process accommodated broad functional group compatibility. The products were generated in excellent yields with excellent to high enantioselectivities, which would be transformed to various axially chiral mols.
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Reference:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics