An article Suppressive activities of KC1-3 on HMGB1-mediated septic responses WOS:000466060000025 published article about ENDOTHELIAL-CELLS; IMPROVES SURVIVAL; ANGELICA-GIGAS; SEPSIS; LIPOPOLYSACCHARIDE; DAMAGE in [Lee, Wonhwa] KRIBB, Aging Res Ctr, Daejeon 34141, South Korea; [Yuseok, O.; Song, Gyu-Yong] Chungnam Natl Univ, Coll Pharm, 99 Daehak Ro, Daejon 34134, South Korea; [Lee, Changhun; Jeong, So Yeon; Bae, Jong-Sup] Kyungpook Natl Univ, BK21 Plus KNU Multiomits Based Creat Drug Res Tea, Pharmaceut Sci Res Inst, Coll Pharm,CMRI, Daegu 41566, South Korea; [Lee, Jee-Hyun; Song, Gyu-Yong] AREZ Co Ltd, 197 Songam Ro, Sejong 30066, South Korea; [Baek, Moon-Chang] Kyungpook Natl Univ, Sch Med, CMRI, Dept Mol Med, Daegu 700422, South Korea in 2019.0, Cited 36.0. The Name is Methyl 3-phenyl-2-propenoate. Through research, I have a further understanding and discovery of 103-26-4. Name: Methyl 3-phenyl-2-propenoate
In the present study, several decursin analogues (KC1-3) were synthesized and evaluated in terms of their antiseptic activities on high mobility group box 1 (HMGB1)-mediated septic responses and survival rate in a mouse model of sepsis. KC1 and KC3, but not KC2, significantly reduced HMGB1 release in lipopolysaccharide (LPS)-activated human umbilical vein endothelial cells (HUVECs) and attenuated the cecal ligation and puncture (CLP)-induced release of HMGB1. Additionally, in vitro analyses revealed that KC1 and KC3 both alleviated HMGB1-mediated vascular disruptions and inhibited hyperpermeability in mice, and in vivo analyses revealed that KC1 and KC3 reduced sepsis-related mortality and tissue injury. Taken together, the present results suggest that KC1 and KC3 both reduced HMGB1 release and septic mortality and, thus, may be useful for the treatment of sepsis.
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Reference:
Article; Weng, Shiue-Shien; Ke, Chih-Shueh; Chen, Fong-Kuang; Lyu, You-Fu; Lin, Guan-Ying; Tetrahedron; vol. 67; 9; (2011); p. 1640 – 1648;,
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