Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 41841-16-1, name is Methyl 2-(4-bromophenyl)acetate, A new synthetic method of this compound is introduced below., category: esters-buliding-blocks
Methyl 2-(4-bromophenyl)propanoate. To a solution of lithium diisopropylamide (2 mol/L, 22 mL, 44 mmol) in tetrahydrofuran (80 mL) was dropwise a solution of methyl 2-(4- bromophenyl)acetate (10 g, 44 mmol) in tetrahydrofuran (20 mL) at -78 C. The mixture solution was stirred for 0.5 hour at that temperature, then iodomethane (8 g, 56 mmol) was added. The mixture was stirred for 10 minutes at – 78 C, then was removed from the cooling bath and stirred for 0.5 hour. The reaction was quenched with sat. ammonium chloride, then diluted with ethyl acetate, washed with water, The organic layer concentrated to dry, purified by column chromatography (silica-gel, petroleum : ethyl acetate= 20 : 1) to give methyl 2-(4- bromophenyl)propanoate as a colorless oil (10 g, 91 %). 1H NMR (300 MHz, CDC13): delta 7.44 (d, J = 9 Hz, 2H), 7.17 (d, J = 9 Hz, 2H), 3.65-3.70 (m, 4H), 1.48 (d, J = 6 Hz, 3H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; CONSTELLATION PHARMACEUTICALS; ALBRECHT, Brian, K.; AUDIA, James, Edmund; COOK, Andrew; GAGNON, Alexandre; HARMANGE, Jean-christophe; NAVESCHUK, Christopher, G.; WO2013/75083; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics