SDS of cas: 103-26-4. Recently I am researching about NF-KAPPA-B; ANTI-INFLAMMATION; CYTOTOXIC CONSTITUENTS; ANTIOXIDANT; EXPRESSION; SUBAMOLIDE; APOPTOSIS; PATHWAYS; LEAVES; CELLS, Saw an article supported by the Hubei Provincial Outstanding Young and Middle-Aged Science and Technology Innovation Team Project [T201813]; Young Scientist Innovation Team Project of Hubei Colleges [T201510]; Hubei Province Health and Family Planning Scientific Research Project [WJ2017Z023]. Published in HINDAWI LTD in LONDON ,Authors: Hao, XC; Sun, WG; Ke, CB; Wang, FQ; Xue, YB; Luo, ZW; Wang, XB; Zhang, JW; Zhang, YH. The CAS is 103-26-4. Through research, I have a further understanding and discovery of Methyl 3-phenyl-2-propenoate
The study determined the chemical constituents and anti-inflammatory effects of leaf oil from Cinnamomum subavenium (CS-LO) that has been used in folk medicine to treat various symptoms including inflammation. The anti-inflammatory effects of the oil were evaluated by LPS-stimulated RAW264.7 cells and the Carr-induced hind mouse paw edema model, respectively. In vitro, nitric oxide (NO), prostaglandin E2 (PGE(2)), TNF-, IL-6, and IL-1 were significantly decreased by CS-LO, and the expression of nuclear factor-B (NF-B) protein was blocked as well. In in vivo, the malondialdehyde (MDA) and paw edema levels were decreased by CS-LO, and the same result came up on the NO and tumor necrosis factor (TNF-a) of serum at the 5th h after Carr injection. In addition, iNOS and COX-2 immunoreactive cells of the paw tissue were decreased significantly by CS-LO (200 mg/kg) in histological examination. The present findings indicated that CS-LO have anti-inflammatory properties, and the effects might be caused through inhibiting iNOS, COX-2, TNF-, IL-1, and IL-6 expression via affecting NF-B pathway, which will provide a power scientific basis for CS-LO to be used as the treatment of inflammatory diseases.
SDS of cas: 103-26-4. Welcome to talk about 103-26-4, If you have any questions, you can contact Hao, XC; Sun, WG; Ke, CB; Wang, FQ; Xue, YB; Luo, ZW; Wang, XB; Zhang, JW; Zhang, YH or send Email.
Reference:
Article; Weng, Shiue-Shien; Ke, Chih-Shueh; Chen, Fong-Kuang; Lyu, You-Fu; Lin, Guan-Ying; Tetrahedron; vol. 67; 9; (2011); p. 1640 – 1648;,
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