These common heterocyclic compound, 35450-36-3, name is Methyl 2-bromo-5-methoxybenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C9H9BrO3
Step B 2-Bromo-5-methoxybenzyl alcohol Lithium aluminum hydride (1.3 eq) was added in portions to a solution of methyl 2-bromo-5-methoxy benzoate (1 eq) in diethyl ether (0.35 M) at 0 C. under N2 and the resulting mixture allowed to warm to RT with stirring for 5 h. Quenched with H2O (3*g LAH), followed sequentially by 15% NaOH solution (3*g LAH), a nd H2O (3*g LAH). The solution was filtered through a scintered glass funnel rinsing with diethyl ether and concentrated in vacuo to give 2-bromo-5-methoxybenzyl alcohol as a clear oil. EI-MS m/z 239, 241 (M+Na)+
The synthetic route of Methyl 2-bromo-5-methoxybenzoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Amgen Inc.; US6514964; (2003); B1;,
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