927-68-4, name is 2-Bromoethyl acetate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 2-Bromoethyl acetate
To a solution of the product of step 1(143 mg, 0.69 mmol) in DMF (1.5 mL) at 0 C, wasadded NaH (60% suspension in mineral oil, 30 mg, 0.76 mmol). The mixture was stirred for 0.5 h followed and 2-bromoethyl acetate (184 mg, 0.12 mL, 1.1 mmol) was added. The reaction was brought to room temperature and stirred overnight. The mixture was diluted with EtOAc, washed with water and brine, dried over Na2504, and concentrated underreduced pressure. The residue was purified by silica gel column chromatography (0-20% gradient MeOH in CH2C12) to afford the title compound (180 mg, 89%) as a colorless oil.?H NMR (500 MHz, CDC13) oe 1.36 (t, J=7.4 Hz, 3H), 1.89-2.00 (m, 2H), 2.03-2.15 (m, 5H), 2.75-2.82 (m, 2H), 2.89 (t, J=6.3 Hz, 2H), 3.99 (q, J=7.4 Hz, 2H), 5.25 (s, 2H)
The synthetic route of 927-68-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PTC THERAPEUTICS, INC.; GERASYUTO, Aleksey, I.; ARNOLD, Michael, A.; CHEN, Guangming; KARP, Gary, Mitchell; QI, Hongyan; TURPOFF, Anthony, A.; WANG, Jiashi; WOLL, Matthew, G.; BRANSTROM, Arthur, A.; NARASIMHAN, Jana; DUMBLE, Melissa, L.; HEDRICK, Jean; WEETALL, Maria, L.; (374 pag.)WO2016/109706; (2016); A1;,
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