Related Products of 15441-07-3,Some common heterocyclic compound, 15441-07-3, name is Methyl 3-(chlorosulfonyl)propanoate, molecular formula is C4H7ClO4S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 14 N-isobutyl-3-amidosulfopropionic Acid To 14.6 parts of isobutylamine and 100 parts of water there are added dropwise at 0 C, with stirring 18.65 parts of methyl 3-chlorosulfonylpropionate and then simultaneously from separate dropping funnels 18.65 parts of methyl 3-chlorosulfonylpropionate and 54 parts of 14.8% caustic soda solution. Stirring is continued for a further hour at 0 C and 4 hours at room temperature; 8.8 parts of sodium hydroxide are added and the mixture is heated at 60 C for 4 hours. The reaction mixture is acidified with a 2N H2 SO4 solution to a pH of 1 and the resulting precipitate is filtered off, washed with 100 parts of water and dried at 40 C/25 mm. Yield: 24.6 parts (59% of theory) of white crystalline N-isobutyl-3-amidosulfopropionic acid, m.p. 132-134 C (after recrystallization from H2 O).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 3-(chlorosulfonyl)propanoate, its application will become more common.
Reference:
Patent; BASF Aktiengesellschaft; US4060522; (1977); A;,
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