Synthetic Route of 538372-37-1,Some common heterocyclic compound, 538372-37-1, name is Methyl 3,4-diamino-2-methoxybenzoate, molecular formula is C9H12N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound 63E (1.3 g, 6.6 mmol)And 3,5-dichlorosalicylaldehyde (1.52 g, 7.95 mmol)Stirring in 25 mL of nitrobenzene for two hours, after cooling to room temperature,A large amount of precipitated precipitated, filtered, and the filter cake was washed with petroleum ether.Compound 63F (2.0 g, 85% yield) was obtained.
The synthetic route of 538372-37-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jiangsu Xiansheng Pharmaceutical Co., Ltd.; Chen Huanming; Liang Bo; Cao Wenjie; Zhang Guiping; Zhao Zhongqiang; Jiang Zhaojian; Zuo Gaolei; Xu Wanmei; Gong Hongju; Zhang Peng; Wang Jianghuai; Li Qingsong; Gao Chunhua; (79 pag.)CN104045552; (2019); B;,
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